Search Results - "Leonardi, Irina"

Gut Mycobiota in Immunity and Inflammatory Disease by Li, Xin V., Leonardi, Irina, Iliev, Iliyan D.

“…The mammalian intestine is colonized by a wealth of microorganisms—including bacteria, viruses, protozoa, and fungi—that are all integrated into a functional…”
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CX3CR1 + mononuclear phagocytes control immunity to intestinal fungi by Leonardi, Irina, Li, Xin, Semon, Alexa, Li, Dalin, Doron, Itai, Putzel, Gregory, Bar, Agnieszka, Prieto, Daniel, Rescigno, Maria, McGovern, Dermot P B, Pla, Jesus, Iliev, Iliyan D

“…Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating host immune homeostasis and…”
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Laboratory mice born to wild mice have natural microbiota and model human immune responses by Rosshart, Stephan P, Herz, Jasmin, Vassallo, Brian G, Hunter, Ashli, Wall, Morgan K, Badger, Jonathan H, McCulloch, John A, Anastasakis, Dimitrios G, Sarshad, Aishe A, Leonardi, Irina, Collins, Nicholas, Blatter, Joshua A, Han, Seong-Ji, Tamoutounour, Samira, Potapova, Svetlana, Foster St Claire, Mark B, Yuan, Wuxing, Sen, Shurjo K, Dreier, Matthew S, Hild, Benedikt, Hafner, Markus, Wang, David, Iliev, Iliyan D, Belkaid, Yasmine, Trinchieri, Giorgio, Rehermann, Barbara

“…Laboratory mouse studies are paramount for understanding basic biological phenomena but also have limitations. These include conflicting results caused by…”
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Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum by Zhang, Xu, Alexander, Noah, Leonardi, Irina, Mason, Christopher, Kirkman, Laura A, Deitsch, Kirk W

“…Malaria parasites possess the remarkable ability to maintain chronic infections that fail to elicit a protective immune response, characteristics that have…”
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Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn’s disease by Doron, Itai, Mesko, Marissa, Li, Xin V., Kusakabe, Takato, Leonardi, Irina, Shaw, Dustin G., Fiers, William D., Lin, Woan-Yu, Bialt-DeCelie, Meghan, Román, Elvira, Longman, Randy S., Pla, Jesus, Wilson, Patrick C., Iliev, Iliyan D.

“…Secretory immunoglobulin A (sIgA) plays an important role in gut barrier protection by shaping the resident microbiota community, restricting the growth of…”
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The Proton-activated Receptor GPR4 Modulates Intestinal Inflammation by Wang, Yu, de Vallière, Cheryl, Imenez Silva, Pedro H, Leonardi, Irina, Gruber, Sven, Gerstgrasser, Alexandra, Melhem, Hassan, Weber, Achim, Leucht, Katharina, Wolfram, Lutz, Hausmann, Martin, Krieg, Carsten, Thomasson, Koray, Boyman, Onur, Frey-Wagner, Isabelle, Rogler, Gerhard, Wagner, Carsten A

“…During active inflammation, intraluminal intestinal pH is decreased in patients with inflammatory bowel disease [IBD]. Acidic pH may play a role in IBD…”
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Beyond the gut by Leonardi, Irina

“…Mycobiota modulate immunity and behavior The microbiota of the gut has been implicated in the development of a variety of pathologies. Though microbiota…”
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Fungal dysbiosis: immunity and interactions at mucosal barriers by Iliev, Iliyan D., Leonardi, Irina

“…Key Points The term dysbiosis has been used to describe disruptions of microbial communities that lead to a shift in steady-state composition that is distinct…”
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Large-Scale Integrative Analysis of Epigenetic Modifications Induced by Isotretinoin, Doxycycline and Metronidazole in Murine Colonic Intestinal Epithelial Cells by Becker, Eugenia, Bengs, Susan, Aluri, Sirisha, Opitz, Lennart, Atrott, Kirstin, Rost, Felix, Leonardi, Irina, Stanzel, Claudia, Raselli, Tina, Kasper, Stephanie, Ruiz, Pedro, Rogler, Gerhard

“…Environmental factors are playing a central role in triggering inflammatory responses in the intestine. There is increasing evidence that the development of…”
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3 MECHANSISMS OF INTESTINAL FUNGI RECOGNITION AND CONTROL by Leonardi, Irina, Iliev, Iliyan

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3 MECHANSISMS OF INTESTINAL FUNGI RECOGNITION AND CONTROL by Leonardi, Irina, Iliev, Iliyan

“…Abstract Background and Objectives Intestinal fungal communities are perturbed in several autoimmune diseases and have been shown to influence disease outcome…”
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Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity by Leonardi, Irina, Gao, Iris H., Lin, Woan-Yu, Allen, Megan, Li, Xin V., Fiers, William D., De Celie, Meghan Bialt, Putzel, Gregory G., Yantiss, Rhonda K., Johncilla, Melanie, Colak, Dilek, Iliev, Iliyan D.

“…Fungal communities (the mycobiota) are an integral part of the gut microbiota, and the disruption of their integrity contributes to local and gut-distal…”
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Immune regulation by fungal strain diversity in inflammatory bowel disease by Li, Xin V., Leonardi, Irina, Putzel, Gregory G., Semon, Alexa, Fiers, William D., Kusakabe, Takato, Lin, Woan-Yu, Gao, Iris H., Doron, Itai, Gutierrez-Guerrero, Alejandra, DeCelie, Meghan B., Carriche, Guilhermina M., Mesko, Marissa, Yang, Chen, Naglik, Julian R., Hube, Bernhard, Scherl, Ellen J., Iliev, Iliyan D.

“…The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial community colonizing the mammalian gastrointestinal tract and has…”
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Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies by Doron, Itai, Leonardi, Irina, Li, Xin V., Fiers, William D., Semon, Alexa, Bialt-DeCelie, Meghan, Migaud, Mélanie, Gao, Iris H., Lin, Woan-Yu, Kusakabe, Takato, Puel, Anne, Iliev, Iliyan D.

“…Antibodies mediate natural and vaccine-induced immunity against viral and bacterial pathogens, whereas fungi represent a widespread kingdom of pathogenic…”
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From Birth and Throughout Life: Fungal Microbiota in Nutrition and Metabolic Health by Fiers, William D, Leonardi, Irina, Iliev, Iliyan D

“…The human gastrointestinal tract is home to a vibrant, diverse ecosystem of prokaryotic and eukaryotic microorganisms. The gut fungi (mycobiota) have recently…”
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Profound mycobiome differences between segregated mouse colonies do not influence Th17 responses to a newly introduced gut fungal commensal by Doron, Itai, Leonardi, Irina, Iliev, Iliyan D.

“…Gut mycobiota dysbiosis can negatively impact the outcome of several diseases of inflammatory origin, suggesting a role of the mycobiota in influencing the…”
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Macrophage interactions with fungi and bacteria in inflammatory bowel disease by Leonardi, Irina, Li, Xin, Iliev, Iliyan D

“…PURPOSE OF REVIEWIn this review, we discuss recent advances into delineating the dual role of intestinal phagocytes in health and during intestinal disease. We…”
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Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses by Barbet, Gaetan, Sander, Leif E., Geswell, Matthew, Leonardi, Irina, Cerutti, Andrea, Iliev, Iliyan, Blander, J. Magarian

“…Live vaccines historically afford superior protection, yet the cellular and molecular mechanisms mediating protective immunity remain unclear. Here we found…”
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22 CX3CR1+ MONONUCLEAR PHAGOCYTES CONTROL IMMUNITY TO INTESTINAL FUNGI by Leonardi, Irina, Iliev, Iliyan, Li, Xin, Semon, Alexa

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Macrophage interactions with fungi and bacteria in IBD by Leonardi, Irina, Li, Xin, Iliev, Iliyan D.

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