Search Results - "Leonard Mole, M."

Short-term exposures to dihaloacetic acids produce dysmorphogenesis in mouse conceptuses in vitro by Sidney Hunter, E., Blanton, Maria R., Rogers, Ellen H., Leonard Mole, M., Andrews, James, Chernoff, Neil

“…The haloacetic acids (HAAs) are a family of xenobiotics found in tap water as a result of drinking water disinfection. Administration of HAAs to rats produces…”
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Influence of the drinking water disinfection by-product dibromoacetic acid on rat estrous cyclicity and ovarian follicular steroid release in vitro by Balchak, Sharon K, Hedge, Joan M, Murr, Ashley S, Leonard Mole, M, Goldman, Jerome M

“…The drinking water disinfection by-product, dibromoacetic acid (DBA) has been reported to affect gonadal functions in the male rat. However, there is little…”
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Constituents of Cannabis sativa L. VII: use of silyl derivatives in routine analysis by Turner, C E, Hadley, K W, Henry, J, Mole, M L

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Critical periods of sensitivity to the developmental toxicity of inhaled methanol in the CD-1 mouse by Rogers, John M., Mole, M. Leonard

“…Exposure of pregnant CD‐1 mice to methanol (MeOH) by inhalation on gestation days (gd) 6–15 results in dose‐related increases in fetal cleft palate,…”
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Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat : A mathematical construct by SETZER, R. Woodrow, LAU, Christopher, MOLE, M. Leonard, COPELAND, M. Frank, ROGERS, John M, KAVLOCKT, Robert J

“…Biologically based dose-response (BBDR) models comprise one way to incorporate mechanistic information into a dose-response assessment to be used for risk…”
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Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat : Acquisition of experimental data by LAU, Christopher, MOLE, M. Leonard, SETZER, R. Woodrow, COPELAND, M. Frank, ROGERS, John M, KAVLOCK, Robert J, SHUEY, Dana L, CAMERON, Annie M, ELLIS, David H, LOGSDON, Tina R, MERRIMAN, Jennifer

“…Biologically based dose-response (BBDR) models represent an emerging approach to improving the current practice of human health-risk assessment. The concept of…”
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Phytochemical screening of Cannabis sativa L. I. Constituents of an Indian variant by Mole, Jr, M L, Turner, C E

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Sample Preparation and High-Performance Liquid Chromatographic Analysis of Deoxyribonucleoside Triphosphates in Individual Rat Embryos by Mole, M.Leonard, Hunter, Deborah L., Gao, Pu, Lau, Christopher

“…A rapid, robust, and sensitive method has been developed to measure concentrations of deoxyribonucleoside triphosphates in individual, day 14 rat embryos by…”
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Developmental toxicity of methanol in whole embryo culture: a comparative study with mouse and rat embryos by Andrews, J E, Ebron-McCoy, M, Logsdon, T R, Mole, L M, Kavlock, R J, Rogers, J M

“…Methanol (MeOH), a widely used industrial solvent, has been proposed as an alternative motor vehicle fuel. Inhaled MeOH is developmentally toxic in both rats…”
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Nucleoside-Mediated Mitigation of 5-Fluorouracil-Induced Toxicity in Synchronized Murine Erythroleukemic Cells by Elstein, Kenneth H., Mole, M.Leonard, Setzer, R.Woodrow, Zucker, Robert M., Kavlock, Robert J., Rogers, John M., Lau, Christopher

“…5-Fluorouracil (5-FU) is a chemotherapeutic agent known to retard embryonic growth and induce cleft palate and limb deformities. The predominant mechanism…”
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Dibromoacetic acid, a prevalent by-product of drinking water disinfection, compromises the synthesis of specific seminiferous tubule proteins following both in vivo and in vitro exposures by Holmes, M, Suarez, J. D, Roberts, N. L, Mole, M. L, Murr, A. S, Klinefelter, G. R

“…Dibromoacetic acid (DBA) is a by‐product of drinking water disinfection that alters spermatogenesis in adult male rats. To identify a mechanism by which DBA…”
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Effect of inhaled methanol on pituitary and testicular hormones in chamber acclimated and non-acclimated rats by Cooper, R L, Mole, M L, Rehnberg, G L, Goldman, J M, McElroy, W K, Hein, J, Stoker, T E

“…Two experiments were conducted in which the acute effects of inhaled methanol on serum hormones associated with reproductive function in the male rat were…”
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High-performance liquid chromatographic assay of biphenyl metabolism by hepatocytes cultured in an embryo/hepatocyte co-culture medium by Mole, M L, Sanders, L, Oglesby, L A

“…A high-performance liquid chromatographic method has been modified for the evaluation of both Phase I and II metabolism of biphenyl by hepatocytes maintained…”
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Influence of ozone on pentobarbital pharmacokinetics in mice by Graham, J A, Menzel, D B, Mole, M L, Miller, F J, Gardner, D E

“…Previous studies have indicated that acute exposure to ambient concentrations of ozone (O3) as low as 196 micrograms/m3 (0.1 ppm) increases pentobarbital…”
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Effect of ozone on serum lipids and lipoproteins in the rat by Mole, Jr, M L, Stead, A G, Gardner, D E, Miller, F J, Graham, J A

“…Exposure of male rats to 0 (air), 1, 1.75, and 3 ppm ozone (O3) 5 hr/day for a total of 10 days resulted in a positive linear relationship between ozone…”
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Effect of NO2 inhalation and vitamin C deficiency on protein and lipid accumulation in the lung by Selgrade, M K, Mole, M L, Miller, F J, Hatch, G E, Gardner, D E, Hu, P C

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The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses by Rogers, J M, Mole, M L, Chernoff, N, Barbee, B D, Turner, C I, Logsdon, T R, Kavlock, R J

“…The developmental toxicity of the alternative motor vehicle fuel methanol was assessed in mice by the inhalation route. Pregnant CD-1 mice were exposed to…”
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Chemical Components of Cannabis sativa by Turner, Carlton E, Mole, M. Leonard

“…To the Editor.—We wish to report the first isolation, to our knowledge, of the amino acid proline and a steroidal mixture of sitosterol, stigmasterol, and…”
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Assessment of offspring development and behavior following gestational exposure to inhaled methanol in the rat by Stanton, M E, Crofton, K M, Gray, L E, Gordon, C J, Boyes, W K, Mole, M L, Peele, D B, Bushnell, P J

“…The prospect of widespread human exposure associated with its use as an alternative fuel has sparked concern about the toxic potential of inhaled methanol…”
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