Search Results - "Leonard, Warren"

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy by Liao, Wei, Lin, Jian-Xin, Leonard, Warren J.

“…Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays pivotal roles in the immune response. Discovered as a T cell growth…”
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Role of thymic stromal lymphopoietin in allergy and beyond by Ebina-Shibuya, Risa, Leonard, Warren J.

“…Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell lineages, including dendritic cells, T cells, B cells, neutrophils,…”
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Biology and regulation of IL-2: from molecular mechanisms to human therapy by Spolski, Rosanne, Li, Peng, Leonard, Warren J.

“…IL-2 was first identified as a growth factor capable of driving the expansion of activated human T cell populations. In the more than 40 years since its…”
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Interleukin-21: a double-edged sword with therapeutic potential by Spolski, Rosanne, Leonard, Warren J.

“…Key Points Interleukin-21 (IL-21) is a pleiotropic cytokine with actions on a broad range of lymphoid, myeloid and epithelial cells. These actions include…”
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New insights into the regulation of T cells by γ c family cytokines by Leonard, Warren J, Rochman, Yrina, Spolski, Rosanne

“…Key Points The common cytokine receptor γ-chain (γ c ) family of cytokines consists of interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-21, each of which…”
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New insights into the regulation of T cells by gamma(c) family cytokines by Rochman, Yrina, Spolski, Rosanne, Leonard, Warren J

“…Common cytokine receptor gamma-chain (gamma(c)) family cytokines have crucial roles in the development, proliferation, survival and differentiation of multiple…”
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Biology of IL‐2 and its therapeutic modulation: Mechanisms and strategies by Mitra, Suman, Leonard, Warren J.

“…Cytokines signal through specific cell surface receptors to broadly regulate immune development, differentiation, proliferation, and survival, thereby…”
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Strategies to therapeutically modulate cytokine action by Leonard, Warren J., Lin, Jian-Xin

“…Cytokines are secreted or membrane-presented molecules that mediate broad cellular functions, including development, differentiation, growth and survival…”
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The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications by Leonard, Warren J., Lin, Jian-Xin, O'Shea, John J.

“…The common cytokine receptor γ chain, γc, is a component of the receptors for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene…”
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Publisher Correction: Role of thymic stromal lymphopoietin in allergy and beyond by Ebina-Shibuya, Risa, Leonard, Warren J.

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Interleukin-21: basic biology and implications for cancer and autoimmunity by Spolski, Rosanne, Leonard, Warren J

“…Interleukin-21 (IL-21), a potent immunomodulatory four-alpha-helical-bundle type I cytokine, is produced by NKT and CD4(+) T cells and has pleiotropic effects…”
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Publisher Correction: Strategies to therapeutically modulate cytokine action by Leonard, Warren J., Lin, Jian-Xin

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Thomas Alexander Waldmann (1930–2021) by Leonard, Warren J.

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Fine-Tuning Cytokine Signals by Lin, Jian-Xin, Leonard, Warren J

“…Cytokines are secreted or otherwise released polypeptide factors that exert autocrine and or paracrine actions, with most cytokines acting in the immune and or…”
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IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation by Liao, Wei, Lin, Jian-Xin, Leonard, Warren J

“…Highlights ► We examined the role of IL-2 in T helper cell differentiation. ► IL-2 induces its own receptor chains, IL-2Rα and IL-2Rβ. ► Additionally, IL-2…”
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The Common Cytokine Receptor γ Chain Family of Cytokines by Lin, Jian-Xin, Leonard, Warren J

“…Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on their sharing the common cytokine receptor γ chain (γc), which was…”
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Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection by Hudson, William H., Gensheimer, Julia, Hashimoto, Masao, Wieland, Andreas, Valanparambil, Rajesh M., Li, Peng, Lin, Jian-Xin, Konieczny, Bogumila T., Im, Se Jin, Freeman, Gordon J., Leonard, Warren J., Kissick, Haydn T., Ahmed, Rafi

“…T cell dysfunction is a characteristic feature of chronic viral infection and cancer. Recent studies in chronic lymphocytic choriomeningitis virus (LCMV)…”
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Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps by Mitra, Suman, Ring, Aaron M., Amarnath, Shoba, Spangler, Jamie B., Li, Peng, Ju, Wei, Fischer, Suzanne, Oh, Jangsuk, Spolski, Rosanne, Weiskopf, Kipp, Kohrt, Holbrook, Foley, Jason E., Rajagopalan, Sumati, Long, Eric O., Fowler, Daniel H., Waldmann, Thomas A., Garcia, K. Christopher, Leonard, Warren J.

“…Interleukin-2 (IL-2) regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits. IL-2 is of considerable…”
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Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages by Liao, Wei, Lin, Jian-Xin, Wang, Lu, Li, Peng, Leonard, Warren J

“…IL-2 is well known for its effects on the proliferation of T cells. Leonard and colleagues demonstrate a mechanism in which IL-2 is critical for supporting T H…”
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Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade by Jadhav, Rohit R., Im, Se Jin, Hu, Bin, Hashimoto, Masao, Li, Peng, Lin, Jian-Xin, Leonard, Warren J., Greenleaf, William J., Ahmed, Rafi, Goronzy, Jorg J.

“…We have recently defined a novel population of PD-1 (programmed cell death 1)+ TCF1 (T cell factor 1)+ virus-specific CD8 T cells that function as resource…”
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