Search Results - "Leonard, T B"

Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma by Kon, Onn M, Sihra, Bhupinder S, Compton, Christopher H, Leonard, Thomas B, Kay, A Barry, Barnes, Neil C

“…There is substantial circumstantial evidence that CD4 lymphocytes have a role in the pathogenesis of chronic asthma. We investigated the efficacy and safety in…”
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Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats by Salmon, Michael, Walsh, David A, Huang, Tung‐Jung, Barnes, Peter J, Leonard, Thomas B, Hay, Douglas W P, Chung, K Fan

“…Airway smooth muscle thickening is a characteristic feature of airway wall remodelling in chronic asthma. We have investigated the role of the leukotrienes in…”
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Dinitrotoluene isomer-specific hepatocarcinogenesis in F344 rats by Leonard, T B, Graichen, M E, Popp, J A

“…The hepatocarcinogenicity of 2,4-dinitrotoluene [(2,4-DNT) CAS: 121-14-2], 2,6-DNT (CAS: 606-20-2), and a representative technical-grade DNT (TDNT) containing…”
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Effects of LTD4 on Human Airway Smooth Muscle Cell Proliferation, Matrix Expression, and Contraction In Vitro: Differential Sensitivity to Cysteinyl Leukotriene Receptor Antagonists by Panettieri, Reynold A., Jr, Tan, Elaine M. L, Ciocca, Vincenzo, Luttmann, Mark A, Leonard, Thomas B, Hay, Douglas W. P

“…The cysteinyl leukotrienes (CysLTs) mimic many of the features of asthma and are implicated in its pathophysiology. Little, however, is known about the effects…”
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Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases by Romano, M C, Eckardt, R D, Bender, P E, Leonard, T B, Straub, K M, Newton, J F

“…omega-Hydroxylation of leukotriene B4 (LTB4) has been reported in human and rodent polymorphonuclear leukocytes; preliminary information indicates that this…”
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Serum gamma glutamyl transferase as a specific indicator of bile duct lesions in the rat liver by Leonard, TB, Neptun, DA, Popp, JA

“…Serum gamma-glutamyl transferase (GGT), a marker of hepatic injury used extensively in humans, has been used rarely in rats because its specificity has not…”
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Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl by Duignan, D B, Sipes, I G, Leonard, T B, Halpert, J R

“…The biochemical basis for the marked difference in the rate of the hepatic metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl (245-HCB) by Beagle dogs and…”
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Inhibition by ranitidine of acetaminophen conjugation and its possible role in ranitidine potentiation of acetaminophen-induced hepatotoxicity by Rogers, S A, Gale, K C, Newton, J F, Dent, J G, Leonard, T B

“…Pretreatment with ranitidine (RA) potentiates the hepatotoxicity of acetaminophen (APAP) in male Fischer 344 rats. The present studies were undertaken to…”
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Methoxyflurane enhances allyl alcohol hepatotoxicity in rats. Possible involvement of increased acrolein formation by Kershaw, W C, Barsotti, D A, Leonard, T B, Dent, J G, Lage, G L

“…The effect of methoxyflurane anesthesia on allyl alcohol-induced hepatotoxicity and the metabolism of allyl alcohol was studied in male rats. Hepatotoxicity…”
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Cholestatic potentials of alpha-naphthylisothiocyanate (ANIT) and beta-naphthylisothiocyanate (BNIT) in the isolated perfused rat liver by Kossor, D C, Handler, J A, Dulik, D M, Meunier, P C, Leonard, T B, Goldstein, R S

“…Previous studies in rats have shown that a single oral dose of alpha-naphthylisothiocyanate (ANIT), but not the regioisomer beta-naphthylisothiocyanate (BNIT),…”
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Peroxidation-dependent and peroxidation-independent mechanisms by which acetaminophen kills cultured rat hepatocytes by Farber, J L, Leonard, T B, Kyle, M E, Nakae, D, Serroni, A, Rogers, S A

“…Acetaminophen killed cultured hepatocytes prepared from male rats induced with 3-methylcholanthrene by two distinct mechanisms. With 0.5 to 5 mM acetaminophen,…”
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A-01 Changes in Fixational Eye Movements (FEMs) Following Concussion by Albrecht, T J, Mehmel, B M, Eagle, S R, Leonard, B T, Marchetti, G F, Zhang, M, Reecher, H M, Snyder, V, Holland, C L, Rossi, E A, Collins, M W, Kontos, A P

“…Abstract Purpose: Identify changes in fixational eye movement (FEMs) outcomes following concussion and assess the association of FEMs outcomes with clinical…”
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Dinitrotoluene isomer-specific enhancement of the expression of diethylnitrosamine-initiated hepatocyte foci by Leonard, T B, Adams, T, Popp, J A

“…Technical grade dinitrotoluene (TDNT) was shown to be a potent hepatocarcinogen in rats; however, ambiguous results were obtained from bioassays which…”
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Bile Duct Obstruction Is not a Prerequisite for Type I Biliary Epithelial Cell Hyperplasia by Kossor, David C., Meunier, Paul C., Dulik, Deanne M., Leonard, Thomas B., Goldstein, Robin S.

“…Biliary obstruction, produced by common bile duct ligation or α-naphthylisothiocyanate (ANIT) treatment in rats, has been associated with the development of…”
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In vitro microsomal metabolism of the leukotriene receptor antagonist, 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid (SK&F 102,081) by Newton, J F, Straub, K M, Dewey, R H, Perchonock, C D, Leonard, T B, McCarthy, M E, Gleason, J G, Eckardt, R D

“…In vivo experiments indicate that the major route of metabolism of SK&F 102,081 [5-(2-dodecylphenyl)-4,6-dithianonanedioic acid] is via omega-oxidation and…”
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The Effect of Smoking on the Transcriptional Regulation of Lung Inflammation in Patients with Chronic Obstructive Pulmonary Disease by Szulakowski, Patryk, Crowther, Ann J. L, Jimenez, Luis A, Donaldson, Kenneth, Mayer, Ruth, Leonard, Thomas B, MacNee, William, Drost, Ellen M

“…Chronic obstructive pulmonary disease (COPD) is believed to result from an abnormal inflammatory response in the lungs to noxious particles and gases usually…”
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Strain difference in rat renal microsomal epoxide hydrolase elevation after mercuric chloride treatment by Kroll, D J, Graichen, M E, Leonard, T B

“…Administration of the nephrotoxicant mercuric chloride (HgCl2) was found to increase microsomal epoxide hydrolase (EH) activity in the kidneys of Fischer 344…”
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Effects of the chrysotherapeutic agents auranofin and gold sodium thiomalate on hepatic and renal drug metabolism and heme metabolism by Leonard, T B, Graichen, M E, Dahm, L J, Dent, J G

“…These studies were designed to investigate the effects of the chrysotherapeutic agents auranofin and myochrysine (GST) on hepatic and renal drug-metabolizing…”
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Effects of adenine nucleosides on RNA synthesis in adenovirus-infected cells. 9-beta-D-Arabinofuranosyladenine as a selective inhibitor of RNA polyadenylation by Rose, K M, Leonard, T B, Carter, T H

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Effects of H2 receptor antagonists on the hepatotoxicity of various chemicals by Leonard, T B, Dent, J G

“…H2 receptor antagonist-hepatotoxicant interactions were evaluated in male Fischer-344 rats. The H2 receptor antagonists, cimetidine, ranitidine, oxmetidine,…”
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