Search Results - "Leonard, R."

Understanding modern-day vaccines: what you need to know by Vetter, Volker, Denizer, Gülhan, Friedland, Leonard R, Krishnan, Jyothsna, Shapiro, Marla

“…Vaccines are considered to be one of the greatest public health achievements of the last century. Depending on the biology of the infection, the disease to be…”
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Assessing Density Functional Theory for Chemically Relevant Open-Shell Transition Metal Reactions by Maurer, Leonard R, Bursch, Markus, Grimme, Stefan, Hansen, Andreas

“…Due to the principle lack of systematic improvement possibilities of density functional theory, careful assessment of the performance of density functional…”
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Classifications In Brief: American Spinal Injury Association (ASIA) Impairment Scale by Roberts, Timothy T., Leonard, Garrett R., Cepela, Daniel J.

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EDP-938 demonstrates efficacy against RSV by Krilov, Leonard R.

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Organic Synthesis in the Solid State via Hydrogen-Bond-Driven Self-Assembly by MacGillivray, Leonard R

“…This Perspective describes how chemists can control intermolecular [2 + 2] photodimerizations in the solid state using small molecules as linear templates. The…”
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Phototriggered Guest Release from a Nonporous Organic Crystal: Remarkable Single-Crystal-to-Single-Crystal Transformation of a Binary Cocrystal Solvate to a Ternary Cocrystal by Yelgaonkar, Shweta P, Campillo-Alvarado, Gonzalo, MacGillivray, Leonard R

“…The development of organic solids for applications in materials science requires a fundamental understanding of how close packing of molecules can affect…”
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Halogen-Bond-Templated [2+2] Photodimerization in the Solid State: Directed Synthesis and Rare Self-Inclusion of a Halogenated Product by Sinnwell, Michael A., MacGillivray, Leonard R.

“…A ditopic halogen‐bond acceptor organizes a diiodooctafluorostilbene for a [2+2] photodimerization reaction to take place between two stilbene molecules in the…”
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Impact of COVID-19 pandemic on routine immunization by Ota, Martin O. C., Badur, Selim, Romano-Mazzotti, Luis, Friedland, Leonard R.

“…The current COVID-19 global pandemic continues to impact healthcare services beyond those directly related to the management of SARS-CoV-2 transmission and…”
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Current State of Respiratory Syncytial Virus Disease and Management by Chatterjee, Archana, Mavunda, Kunjana, Krilov, Leonard R.

“…Respiratory syncytial virus (RSV) is a major cause of hospitalizations due to pneumonia and bronchiolitis. Substantial morbidity and socioeconomic burden are…”
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Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses by Thwe, Phyu M., Pelgrom, Leonard R., Cooper, Rachel, Beauchamp, Saritha, Reisz, Julie A., D’Alessandro, Angelo, Everts, Bart, Amiel, Eyal

“…Dendritic cell (DC) activation by Toll-like receptor (TLR) agonists causes rapid glycolytic reprogramming that is required to meet the metabolic demands of…”
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Size-Dependent Mechanical Properties of a Metal–Organic Framework: Increase in Flexibility of ZIF‑8 by Crystal Downsizing by Tiba, Al A, Tivanski, Alexei V, MacGillivray, Leonard R

“…Size engineering is an emerging strategy to modulate the mechanical properties of crystalline materials. Herein, micro- and nanodimensional single crystals of…”
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Messenger RNA Vaccine in Mother's Milk-Reply by Hanna, Nazeeh, Clauss, Christie, Krilov, Leonard R

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Dendritic cells are what they eat: how their metabolism shapes T helper cell polarization by Patente, Thiago A, Pelgrom, Leonard R, Everts, Bart

“…•DCs with different Th cell-polarizing properties have distinct metabolic profiles.•Metabolic regulators mTOR, AMPK, and PPAR-γ play key roles in Th cell…”
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Hydrogen- and Halogen-Bonded Binary Cocrystals with Ditopic Components: Systematic Structural and Photoreactivity Properties That Provide Access to a Completed Series of Symmetrical Cyclobutanes by Quentin, Jay, MacGillivray, Leonard R

“…A series of binary cocrystals involving the ditopic hydrogen- and halogen-bond (H- and X-bond, respectively) donors resorcinol (res) and hydroquinone (hq), and…”
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Ceftolozane/tazobactam activity against drug-resistant Enterobacteriaceae and Pseudomonas aeruginosa causing urinary tract and intraabdominal infections in Europe: report from an antimicrobial surveillance programme (2012-15) by Pfaller, Michael A, Bassetti, Matteo, Duncan, Leonard R, Castanheira, Mariana

“…To evaluate the in vitro activity of ceftolozane/tazobactam and comparators tested against European isolates of Enterobacteriaceae and Pseudomonas aeruginosa…”
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A molecular T-pentomino for separating BTEX hydrocarbons by Hartwick, Christopher J., Reinheimer, Eric W., MacGillivray, Leonard R.

“…Methods to separate molecules (e.g., petrochemicals) are exceedingly important industrially. A common approach for separations is to crystallize a host…”
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Halogen versus Hydrogen Bonding in Binary Cocrystals: Novel Conformation a Coformer with [2+2] Photoreactivity of Criss‐Crossed C=C Bonds by Quentin, Jay, MacGillivray, Leonard R.

“…A series of cocrystals involving the hydrogen‐ and halogen‐bond donor coformers catechol (cat) and 1,2‐diiodotetrafluorobenzene (1,2‐di‐I‐tFb), respectively,…”
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Respiratory Syncytial Virus Immunoprophylaxis: Issues in Short-term and Longer-term Impact by Krilov, Leonard R

“…Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection (LRTI) in infants and young children, accounting for upwards of 130…”
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The sarcomere force-length relationship in an intact muscle-tendon unit by Moo, Eng Kuan, Leonard, Timothy R, Herzog, Walter

“…The periodic striation pattern in skeletal muscle reflects the length of the basic contractile unit: the sarcomere. More than half a century ago, Gordon,…”
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Antimicrobial Susceptibility of Enterobacteriaceae and Pseudomonas aeruginosa Isolates from United States Medical Centers Stratified by Infection Type: Results from the International Network for Optimal Resistance Monitoring (INFORM) Surveillance Program, 2015–2016 by Sader, Helio S., Castanheira, Mariana, Duncan, Leonard R., Flamm, Robert K.

“…A total of 18,656 Enterobacteriaceae and 4,175 Pseudomonas aeruginosa were consecutively collected from 85 US hospitals and tested for susceptibility by broth…”
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