Search Results - "Leonard, Paul"

Characterisation and Modeling of Gallium Nitride Power Semiconductor Devices Dynamic On-State Resistance by Li, Ke, Evans, Paul Leonard, Johnson, Christopher Mark

“…Gallium nitride high-electron-mobility transistors (GaN-HEMTs) suffer from trapping effects that increases device on-state resistance (RDS(on)) above its…”
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Circuit‐theory applications to connectivity science and conservation by Dickson, Brett G., Albano, Christine M., Anantharaman, Ranjan, Beier, Paul, Fargione, Joe, Graves, Tabitha A., Gray, Miranda E., Hall, Kimberly R., Lawler, Josh J., Leonard, Paul B., Littlefield, Caitlin E., McClure, Meredith L., Novembre, John, Schloss, Carrie A., Schumaker, Nathan H., Shah, Viral B., Theobald, David M.

“…Conservation practitioners have long recognized ecological connectivity as a global priority for preserving biodiversity and ecosystem function. In the early…”
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Single cell screening approaches for antibody discovery by Fitzgerald, Valerie, Leonard, Paul

“…•Overview of traditional antibody screening methods & introduction to single cell screening.•Description of a selection of single cell analysis (SCA) tools for…”
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Accurate Measurement of Dynamic on-State Resistances of GaN Devices Under Reverse and Forward Conduction in High Frequency Power Converter by Li, Ke, Videt, Arnaud, Idir, Nadir, Evans, Paul Leonard, Johnson, Christopher Mark

“…Because of trapped charges in GaN transistor structure, device dynamic on -state resistance <inline-formula><tex-math…”
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Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation by Liu, Zhiqing, Chen, Haiying, Wang, Pingyuan, Li, Yi, Wold, Eric A, Leonard, Paul G, Joseph, Sarah, Brasier, Allan R, Tian, Bing, Zhou, Jia

“…Bromodomain-containing protein 4 (BRD4) represents a promising drug target for anti-inflammatory therapeutics. Herein, we report the design, synthesis, and…”
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Interacting Social and Environmental Predictors for the Spatial Distribution of Conservation Lands by Baldwin, Robert F, Leonard, Paul B

“…Conservation decisions should be evaluated for how they meet conservation goals at multiple spatial extents. Conservation easements are land use decisions…”
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Blocking c-Met–mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors by Du, Yi, Yamaguchi, Hirohito, Wei, Yongkun, Hsu, Jennifer L, Wang, Hung-Ling, Hsu, Yi-Hsin, Lin, Wan-Chi, Yu, Wen-Hsuan, Leonard, Paul G, Lee, Gilbert R, Chen, Mei-Kuang, Nakai, Katsuya, Hsu, Ming-Chuan, Chen, Chun-Te, Sun, Ye, Wu, Yun, Chang, Wei-Chao, Huang, Wen-Chien, Liu, Chien-Liang, Chang, Yuan-Ching, Chen, Chung-Hsuan, Park, Morag, Jones, Philip, Hortobagyi, Gabriel N, Hung, Mien-Chie

“…c-Met binds to and phosphorylates PARP1 in cancer cells, thereby reducing PARP1 binding to a PARP inhibitor; c-Met and PARP inhibitor combination therapy shows…”
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Cardiac biomarkers and the case for point-of-care testing by McDonnell, Barry, Hearty, Stephen, Leonard, Paul, O'Kennedy, Richard

“…Cardiovascular disease (CVD) is the single greatest cause of adult mortality in the western world and, consequently, places a massive burden on healthcare…”
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Landscape-scale conservation design across biotic realms: sequential integration of aquatic and terrestrial landscapes by Leonard, Paul B., Baldwin, Robert F., Hanks, R. Daniel

“…Systematic conservation planning has been used extensively throughout the world to identify important areas for maintaining biodiversity and functional…”
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H-NS forms a superhelical protein scaffold for DNA condensation by Arold, Stefan T., Leonard, Paul G., Parkinson, Gary N., Ladbury, John E., Matthews, Brian W.

“…The histone-like nucleoid structuring (H-NS) protein plays a fundamental role in DNA condensation and is a key regulator of enterobacterial gene expression in…”
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Discovery, X‑ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site by Liu, Zhiqing, Li, Yi, Chen, Haiying, Lai, Hsien-Tsung, Wang, Pingyuan, Wu, Shwu-Yuan, Wold, Eric A, Leonard, Paul G, Joseph, Sarah, Hu, Haitao, Chiang, Cheng-Ming, Brasier, Allan R, Tian, Bing, Zhou, Jia

“…Bromodomain-containing protein 4 (BRD4) is an emerging epigenetic drug target for intractable inflammatory disorders. The lack of highly selective inhibitors…”
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Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation by Leonard, Paul G., Golemi-Kotra, Dasantila, Stock, Ann M.

“…Staphylococcus aureus VraR, a vancomycin-resistance-associated response regulator, activates a cell-wall-stress stimulon in response to antibiotics that…”
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The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable by Benod, Cindy, Villagomez, Rosa, Filgueira, Carly S, Hwang, Peter K, Leonard, Paul G, Poncet-Montange, Guillaume, Rajagopalan, Senapathy, Fletterick, Robert J, Gustafsson, Jan-Åke, Webb, Paul

“…Nuclear receptors (NRs) are an important group of ligand-dependent transcriptional factors. Presently, no natural or synthetic ligand has been identified for a…”
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The N‐Terminal Domain of ALS‐Linked TDP‐43 Assembles without Misfolding by Tsoi, Phoebe S., Choi, Kyoung‐Jae, Leonard, Paul G., Sizovs, Antons, Moosa, Mahdi Muhammad, MacKenzie, Kevin R., Ferreon, Josephine C., Ferreon, Allan Chris M.

“…Transactivation response element (TAR) DNA‐binding protein 43 (TDP‐43) misfolding is implicated in several neurodegenerative diseases characterized by…”
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Immunoaffinity Chromatography: Concepts and Applications by Fitzgerald, Jenny, Leonard, Paul, Darcy, Elaine, Sharma, Shikha, O'Kennedy, Richard

“…Antibody-based separation methods, such as immunoaffinity chromatography (IAC), are powerful purification and isolation techniques. Antibodies isolated using…”
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SF2312 is a natural phosphonate inhibitor of enolase by Leonard, Paul G, Satani, Nikunj, Maxwell, David, Lin, Yu-Hsi, Hammoudi, Naima, Peng, Zhenghong, Pisaneschi, Federica, Link, Todd M, Lee, Gilbert R, Sun, Duoli, Prasad, Basvoju A Bhanu, Di Francesco, Maria Emilia, Czako, Barbara, Asara, John M, Wang, Y Alan, Bornmann, William, DePinho, Ronald A, Muller, Florian L

“…SF2312, a phosphonate antibiotic, directly binds and inhibits the activity of the glycolytic enzyme enolase and is selectively toxic to ENO1 -deleted glioma…”
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Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties by Soth, Michael J, Le, Kang, Di Francesco, Maria Emilia, Hamilton, Matthew M, Liu, Gang, Burke, Jason P, Carroll, Chris L, Kovacs, Jeffrey J, Bardenhagen, Jennifer P, Bristow, Christopher A, Cardozo, Mario, Czako, Barbara, de Stanchina, Elisa, Feng, Ningping, Garvey, Jill R, Gay, Jason P, Do, Mary K. Geck, Greer, Jennifer, Han, Michelle, Harris, Angela, Herrera, Zachary, Huang, Sha, Giuliani, Virginia, Jiang, Yongying, Johnson, Sarah B, Johnson, Troy A, Kang, Zhijun, Leonard, Paul G, Liu, Zhen, McAfoos, Timothy, Miller, Meredith, Morlacchi, Pietro, Mullinax, Robert A, Palmer, Wylie S, Pang, Jihai, Rogers, Norma, Rudin, Charles M, Shepard, Hannah E, Spencer, Nakia D, Theroff, Jay, Wu, Qi, Xu, Alan, Yau, Ju Anne, Draetta, Giulio, Toniatti, Carlo, Heffernan, Timothy P, Jones, Philip

“…Inhibition of glutaminase-1 (GLS-1) hampers the proliferation of tumor cells reliant on glutamine. Known glutaminase inhibitors have potential limitations, and…”
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The Future of Landscape Conservation by BALDWIN, ROBERT F., TROMBULAK, STEPHEN C., LEONARD, PAUL B., NOSS, REED F., HILTY, JODI A., POSSINGHAM, HUGH P., SCARLETT, LYNN, ANDERSON, MARK G.

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gflow: software for modelling circuit theory‐based connectivity at any scale by Leonard, Paul B., Duffy, Edward B., Baldwin, Robert F., McRae, Brad H., Shah, Viral B., Mohapatra, Tanmay K., Poisot, Timothée

“…Summary Increasing habitat connectivity is important for mitigating the effects of climate change, landscape fragmentation and habitat loss for biodiversity…”
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An Adaptive Mutation in Enterococcus faecium LiaR Associated with Antimicrobial Peptide Resistance Mimics Phosphorylation and Stabilizes LiaR in an Activated State by Davlieva, Milya, Tovar-Yanez, Angel, DeBruler, Kimberly, Leonard, Paul G., Zianni, Michael R., Arias, Cesar A., Shamoo, Yousif

“…The cyclic antimicrobial lipopeptide daptomycin (DAP) triggers the LiaFSR membrane stress response pathway in enterococci and many other Gram-positive…”
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