Search Results - "Leonard, P"

increasing importance of herbicides in worldwide crop production by Gianessi, Leonard P

“…Herbicide use is increasingly being adopted around the world. Many developing countries (India, China, Bangladesh) are facing shortages of workers to hand weed…”
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The Economics of Reproducibility in Preclinical Research by Freedman, Leonard P, Cockburn, Iain M, Simcoe, Timothy S

“…Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug…”
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Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection by Sheth, Sandeep, Mukherjea, Debashree, Rybak, Leonard P, Ramkumar, Vickram

“…Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the…”
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Reverse Dual-Ion Battery via a ZnCl2 Water-in-Salt Electrolyte by Wu, Xianyong, Xu, Yunkai, Zhang, Chong, Leonard, Daniel P, Markir, Aaron, Lu, Jun, Ji, Xiulei

“…Dual-ion batteries are known for anion storage in the cathode coupled to cation incorporation in the anode. We flip the sequence of the anion/cation-storage…”
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Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway by Sheth, Sandeep, Jajoo, Sarvesh, Kaur, Tejbeer, Mukherjea, Debashree, Sheehan, Kelly, Rybak, Leonard P, Ramkumar, Vickram

“…The consumption of foods containing resveratrol produces significant health benefits. Resveratrol inhibits cancer by reducing cell proliferation and metastasis…”
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Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction by Haigis, Marcia C, Guarente, Leonard P

“…Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1-7…”
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A Decade of Active Surveillance in the PRIAS Study: An Update and Evaluation of the Criteria Used to Recommend a Switch to Active Treatment by Bokhorst, Leonard P, Valdagni, Riccardo, Rannikko, Antti, Kakehi, Yoshiyuki, Pickles, Tom, Bangma, Chris H, Roobol, Monique J

“…Abstract Background The Prostate Cancer Research International Active Surveillance (PRIAS) study was initiated a decade ago to study the most optimal selection…”
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Why Solvent Response Contributions to Solvation Free Energies Are Compatible with Ben-Naim’s Theorem by Heinz, Leonard P., Grubmüller, Helmut

“…We resolve a seeming paradox arising from a common misinterpretation of Ben-Naim's theorem, which rests on the decomposition of the Hamiltonian of a molecular…”
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Spatially resolved free-energy contributions of native fold and molten-globule-like Crambin by Heinz, Leonard P., Grubmüller, Helmut

“…The folding stability of a protein is governed by the free-energy difference between its folded and unfolded states, which results from a delicate balance of…”
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The Increasing Urgency for Standards in Basic Biologic Research by FREEDMAN, Leonard P, INGLESE, James

“…Research advances build upon the validity and reproducibility of previously published data and findings. Yet irreproducibility in basic biologic and…”
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Adenosine receptors: expression, function and regulation by Sheth, Sandeep, Brito, Rafael, Mukherjea, Debashree, Rybak, Leonard P, Ramkumar, Vickram

“…Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR…”
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Tight docking of membranes before fusion represents a metastable state with unique properties by Witkowska, Agata, Heinz, Leonard P., Grubmüller, Helmut, Jahn, Reinhard

“…Membrane fusion is fundamental to biological processes as diverse as membrane trafficking or viral infection. Proteins catalyzing membrane fusion need to…”
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Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial by Shaw, Alice T, Felip, Enriqueta, Bauer, Todd M, Besse, Benjamin, Navarro, Alejandro, Postel-Vinay, Sophie, Gainor, Justin F, Johnson, Melissa, Dietrich, Jorg, James, Leonard P, Clancy, Jill S, Chen, Joseph, Martini, Jean-François, Abbattista, Antonello, Solomon, Benjamin J

“…Most patients with anaplastic lymphoma kinase (ALK)-rearranged or ROS proto-oncogene 1 (ROS1)-rearranged non-small-cell lung cancer (NSCLC) are sensitive to…”
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Cisplatin and Aminoglycoside Antibiotics: Hearing Loss and Its Prevention by Schacht, Jochen, Talaska, Andra E., Rybak, Leonard P.

“…This review introduces the pathology of aminoglycoside antibiotic and the cisplatin chemotherapy classes of drugs, discusses oxidative stress in the inner ear…”
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Engineered symbionts activate honey bee immunity and limit pathogens by Leonard, Sean P, Powell, J Elijah, Perutka, Jiri, Geng, Peng, Heckmann, Luke C, Horak, Richard D, Davies, Bryan W, Ellington, Andrew D, Barrick, Jeffrey E, Moran, Nancy A

“…Honey bees are essential pollinators threatened by colony losses linked to the spread of parasites and pathogens. Here, we report a new approach for…”
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Water-in-Salt Electrolyte for Potassium-Ion Batteries by Leonard, Daniel P, Wei, Zhixuan, Chen, Gang, Du, Fei, Ji, Xiulei

“…Concentrated potassium acetate as a water-in-salt electrolyte provides a wide potential window from −1.7 to 1.5 V vs Ag/AgClKCl sat.. It facilitates the…”
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Monoclonal Antibody Therapy for B-Cell Non-Hodgkin's Lymphoma by Cheson, Bruce D, Leonard, John P

“…Treatment of B-cell non-Hodgkin's lymphoma has become more successful, largely owing to the availability of therapeutic monoclonal antibodies, which may avoid…”
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Follicular lymphoma grade 3B: low grade, high grade or should we skip the grade? by Mulvey, Erin, Leonard, John P

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Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study by Solomon, Benjamin J, Besse, Benjamin, Bauer, Todd M, Felip, Enriqueta, Soo, Ross A, Camidge, D Ross, Chiari, Rita, Bearz, Alessandra, Lin, Chia-Chi, Gadgeel, Shirish M, Riely, Gregory J, Tan, Eng Huat, Seto, Takashi, James, Leonard P, Clancy, Jill S, Abbattista, Antonello, Martini, Jean-François, Chen, Joseph, Peltz, Gerson, Thurm, Holger, Ou, Sai-Hong Ignatius, Shaw, Alice T

“…Lorlatinib is a potent, brain-penetrant, third-generation inhibitor of ALK and ROS1 tyrosine kinases with broad coverage of ALK mutations. In a phase 1 study,…”
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Magnetic Resonance Imaging in Active Surveillance of Prostate Cancer: A Systematic Review by Schoots, Ivo G, Petrides, Neophytos, Giganti, Francesco, Bokhorst, Leonard P, Rannikko, Antti, Klotz, Laurence, Villers, Arnauld, Hugosson, Jonas, Moore, Caroline M

“…Abstract Context There is great interest in using magnetic resonance imaging (MRI) for men on active surveillance for prostate cancer. Objective To…”
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