Search Results - "Leonard, M. Kathryn"

NME1 Drives Expansion of Melanoma Cells with Enhanced Tumor Growth and Metastatic Properties by Wang, Ying, Leonard, M Kathryn, Snyder, Devin E, Fisher, Matthew L, Eckert, Richard L, Kaetzel, David M

“…Melanoma is a lethal skin cancer prone to progression and metastasis, and resistant to therapy. Metastasis and therapy resistance of melanoma and other cancers…”
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Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma by Pamidimukkala, Nidhi, Puts, Gemma S., Kathryn Leonard, M., Snyder, Devin, Dabernat, Sandrine, De Fabo, Edward C., Noonan, Frances P., Slominski, Andrzej, Merlino, Glenn, Kaetzel, David M.

“…NME1 is a metastasis-suppressor gene (MSG), capable of suppressing metastatic activity in cell lines of melanoma, breast carcinoma and other cancer origins…”
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Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients by Leonard, M. Kathryn, Puts, Gemma S., Pamidimukkala, Nidhi, Adhikary, Gautam, Xu, Yili, Kwok, Eric, Jin, Yuxin, Snyder, Devin, Matsangos, Nicolette, Novak, Marián, Mahurkar, Anup, Shetty, Amol C., Slominski, Radomir M., De Fabo, Edward C., Noonan, Frances P., Day, Chi-Ping, Rigi, Mohammed, Slominski, Andrzej T., Webb, Michelle G., Craig, David W., Merlino, Glenn, Eckert, Richard L., Carpten, John D., Manojlovic, Zarko, Kaetzel, David M.

“…Hepatocyte growth factor-overexpressing mice that harbor a deletion of the Ink4a / p16 locus (HP mice) form melanomas with low metastatic potential in response…”
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Flexible growth and body mass predict physiological condition at fledging in the synchronously breeding European starling, Sturnus vulgaris by Allen, Joshua M, Hodinka, Brett L, Hall, Hannah M, Leonard, Kathryn M, Williams, Tony D

“…Recent studies have reported beneficial carryover effects of juvenile development that predict interspecific survival differences at independence. Yet, traits…”
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The HGF/SF Mouse Model of UV-Induced Melanoma as an In Vivo Sensor for Metastasis-Regulating Gene by Leonard, M Kathryn, Pamidimukkala, Nidhi, Puts, Gemma S, Snyder, Devin E, Slominski, Andrzej T, Kaetzel, David M

“…Cutaneous malignant melanoma is an aggressive and potentially lethal form of skin cancer, particularly in its advanced and therapy-resistant stages, and the…”
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Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus by Tarasen, Ashley, Carlson, J Andrew, Leonard, M Kathryn, Merlino, Glenn, Kaetzel, David, Slominski, Andrzej T

“…Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type…”
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Timing of egg-laying in relation to a female’s social environment in European starlings by Leonard, Kathryn M, Williams, Tony D

“…It is widely assumed that female birds use nonphotic supplemental cues, including social factors, to fine-tune timing of egg-laying to local conditions, but…”
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Long-term, not short-term, temperatures predict timing of egg laying in European Starling by Leonard, Kathryn M., Williams, Tony D.

“…Temperature, particularly within ∼1 month of egg laying, is thought to be an important, short-term cue used by female birds to calibrate timing of breeding to…”
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Nuclear functions of NME proteins by Puts, Gemma S, Leonard, M Kathryn, Pamidimukkala, Nidhi V, Snyder, Devin E, Kaetzel, David M

“…The NME family of proteins is composed of 10 isoforms, designated NME1-10, which are diverse in their enzymatic activities and patterns of subcellular…”
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Decoupling of body size, physiological state and subsequent performance in a developmentally manipulated songbird by Allen, Joshua M., Hodinka, Brett L., Hall, Hannah M., Leonard, Kathryn M., Barbera, Raven A., Desjardin, Genavieve C., Williams, Tony D.

“…It is generally assumed that larger juveniles are more physiologically mature, hence their overall condition and subsequent performance are higher. Some taxa…”
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The metastasis suppressor NME1 inhibits melanoma cell motility via direct transcriptional induction of the integrin beta-3 gene by Leonard, M. Kathryn, Novak, Marián, Snyder, Devin, Snow, Grace, Pamidimukkala, Nidhi, McCorkle, Joseph R., Yang, Xiuwei H., Kaetzel, David M.

“…Expression of the metastasis suppressor NME1 in melanoma is associated with reduced cellular motility, invasion, and metastasis, but mechanisms underlying…”
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TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98–HOXD13 mouse model of MDS by Monlish, Darlene A., Greenberg, Zev J., Bhatt, Sima T., Leonard, Kathryn M., Romine, Molly P., Dong, Qian, Bendesky, Lauren, Duncavage, Eric J., Magee, Jeffrey A., Schuettpelz, Laura G.

“…•Chronic stimulation of TLR2/6, but not TLR1/2, accelerates leukemic transformation in the NHD13 mouse model of MDS.•Conversely, loss of TLR6, but not TLR1,…”
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Correction: Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients by Leonard, M. Kathryn, Puts, Gemma S., Pamidimukkala, Nidhi, Adhikary, Gautam, Xu, Yili, Kwok, Eric, Jin, Yuxin, Snyder, Devin, Matsangos, Nicolette, Novak, Marián, Mahurkar, Anup, Shetty, Amol C., Slominski, Radomir M., De Fabo, Edward C., Noonan, Frances P., Day, Chi-Ping, Rigi, Mohammed, Slominski, Andrzej T., Webb, Michelle G., Craig, David W., Merlino, Glenn, Eckert, Richard L., Carpten, John D., Manojlovic, Zarko, Kaetzel, David M.

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Identification of a gene expression signature associated with the metastasis suppressor function of NME1: prognostic value in human melanoma by Leonard, M Kathryn, McCorkle, Joseph R, Snyder, Devin E, Novak, Marian, Zhang, Qingbei, Shetty, Amol C, Mahurkar, Anup A, Kaetzel, David M

“…Although NME1 is well known for its ability to suppress metastasis of melanoma, the molecular mechanisms underlying this activity are not completely…”
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Long-term, not short-term, temperatures predict timing of egg laying in European Starling: Las temperaturas de largo plazo, no de corto plazo, predicen el momento de la puesta de huevos en Sturnus vulgaris by Leonard, Kathryn M, Williams, Tony D

“…Temperature, particularly within ~1 month of egg laying, is thought to be an important, short-term cue used by female birds to calibrate timing of breeding to…”
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Abstract 4847: NME1 mediates a switch in beta integrin subunits that correlates with prolonged patient survival by Leonard, M. Kathryn, Snow, Grace, Novak, Marián, McCorkle, Joseph R., Yang, Xiuwei H., Belkin, Alexey, Kaetzel, David M.

“…Expression of the metastasis suppressor NME1 in melanoma is associated with reduced cellular motility, invasion, and metastasis, but the molecular mechanisms…”
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Abstract 3257: NME1 mediates a switch in expression of beta integrin subunits that correlates with prolonged patient survival by Leonard, M. Kathryn, Novak, Marian, Yang, Xiuwei, Belkin, Alexey, Kaetzel, David

“…Expression of the metastasis suppressor NME1 in melanoma is associated with reduced cellular motility and invasion in vitro and metastasis in vivo, but the…”
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Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus by Tarasen, Ashley, Carlson, J Andrew, Leonard, M Kathryn, Merlino, Glenn, Kaetzel, David, Slominski, Andrzej T

“…Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type…”
Get full text