Search Results - "Leonard, Jeffrey"
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Clinical Manifestations of Chiari I Malformation
Published in Neurosurgery clinics of North America (01-01-2023)“…Chiari 1 malformation (CM1) includes a spectrum of clinical manifestations. These signs and symptoms result from compression at the cervicomedullary junction…”
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BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma
Published in Acta neuropathologica (01-06-2013)“…Gangliogliomas are typically low-grade neuroepithelial tumors seen in the pediatric and young adult populations. Despite their often bland histologic…”
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Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons
Published in Nature communications (12-07-2021)“…Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in…”
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Hospital Case-Volume and Patient Outcomes Following Pediatric Brain Tumor Surgery in the Pediatric Health Information System
Published in Pediatric neurology (01-08-2022)“…BACKGROUNDMarkers of quality of care in various surgical specialties have been shown to correlate with hospital volumes. This study investigates the effect of…”
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Cervical spine injury patterns in children
Published in Pediatrics (Evanston) (01-05-2014)“…Pediatric cervical spine injuries (CSIs) are rare and differ from adult CSIs. Our objective was to describe CSIs in a large, representative cohort of children…”
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Cervical Spine Injury Risk Factors in Children With Blunt Trauma
Published in Pediatrics (Evanston) (01-07-2019)“…Adult prediction rules for cervical spine injury (CSI) exist; however, pediatric rules do not. Our objectives were to determine test accuracies of…”
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Advances in the Field of Chiari I Malformation and Integrating Them into Clinical Practice
Published in Neurosurgery clinics of North America (01-01-2023)Get full text
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De novo transcriptome assembly and analyses of gene expression during photomorphogenesis in diploid wheat Triticum monococcum
Published in PloS one (12-05-2014)“…Triticum monococcum (2n) is a close ancestor of T. urartu, the A-genome progenitor of cultivated hexaploid wheat, and is therefore a useful model for the study…”
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Epileptic versus neuro-oncological focus of management in pediatric patients with concurrent primary brain lesion and seizures: a systematic review
Published in Journal of neurosurgery. Pediatrics (01-11-2023)“…OBJECTIVE Seizures can be a debilitating manifestation of underlying neoplastic intracranial pathology. Existing literature offers a paucity of scientific…”
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Editorial. The ongoing dilemma of incidentalomas
Published in Journal of neurosurgery. Pediatrics (01-02-2022)Get full text
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Effect of implementation of a paediatric neurocritical care programme on outcomes after severe traumatic brain injury: a retrospective cohort study
Published in Lancet neurology (2013)“…Summary Background Outcomes after traumatic brain injury are worsened by secondary insults; modern intensive-care units address such challenges through use of…”
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Pediatric Endoscopic Endonasal Skull Base Surgery: A Retrospective Review Over 11 Years
Published in World neurosurgery (01-02-2023)“…To show the safety and efficacy of the endoscopic endonasal approach (EEA) for skull base surgery in pediatric patients through descriptive analysis of cases…”
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Mouse Low-Grade Gliomas Contain Cancer Stem Cells with Unique Molecular and Functional Properties
Published in Cell reports (Cambridge) (24-03-2015)“…The availability of adult malignant glioma stem cells (GSCs) has provided unprecedented opportunities to identify the mechanisms underlying treatment…”
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Efficacy of venetoclax in high risk relapsed mantle cell lymphoma (MCL) ‐ outcomes and mutation profile from venetoclax resistant MCL patients
Published in American journal of hematology (01-06-2020)“…Venetoclax is effective in relapsed patients with mantle cell lymphoma (MCL). Mechanisms of resistance to venetoclax in MCL are poorly understood. We describe…”
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Impact of Etiology on Seizure and Quantitative Functional Outcomes in Children with Cerebral Palsy and Medically Intractable Epilepsy Undergoing Hemispherotomy/Hemispherectomy
Published in World neurosurgery (01-07-2023)“…To compare functional and seizure outcomes in children with vascular and dysplastic etiologies of cerebral palsy and medically intractable epilepsy following…”
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Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma
Published in Genome research (01-03-2013)“…Low-grade brain tumors (pilocytic astrocytomas) arising in the neurofibromatosis type 1 (NF1) inherited cancer predisposition syndrome are hypothesized to…”
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Factors Associated With Cervical Spine Injury in Children After Blunt Trauma
Published in Annals of emergency medicine (01-08-2011)“…Study objective Cervical spine injuries in children are rare. However, immobilization and imaging for potential cervical spine injury after trauma are common…”
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Children With Severe Traumatic Brain Injury, Intracranial Pressure, Cerebral Perfusion Pressure, What Does it Mean? A Review of the Literature
Published in Pediatric neurology (01-05-2019)“…Severe traumatic brain injury is a leading cause of morbidity and mortality in children. In 2003 the Brain Trauma Foundation released guidelines that have…”
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