Search Results - "Leonard, JP"

Responsive lanthanide luminescent cyclen complexes: from switching/sensing to supramolecular architectures by Gunnlaugsson, Thorfinnur, Leonard, Joseph P

“…This article highlights some of the recent developments in the use of responsive cyclen based lanthanide luminescent devices, focusing on Eu(III), Tb(III),…”
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Highly Selective Colorimetric Naked-Eye Cu(II) Detection Using an Azobenzene Chemosensor by Gunnlaugsson, Thorfinnur, Leonard, Joseph P, Murray, Niamh S

“…Colorimetric azobenzene based chemosensors 1 and 2 were designed for detection of transition-metal ions such as Cu(II) under physiological pH conditions. The…”
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Luminescent Eu(III) and Tb(III) complexes: developing lanthanide luminescent-based devices by Leonard, Joseph P, Gunnlaugsson, Thorfinnur

“…This mini review gives some highlights of the work recently carried out in our research group in Dublin on the developments of lanthanide luminescent devices,…”
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PET Predicts Prognosis After 1 Cycle of Chemotherapy in Aggressive Lymphoma and Hodgkin's Disease by Kostakoglu, Lale, Coleman, Morton, Leonard, John P, Kuji, Ichiei, Zoe, Holly, Goldsmith, Stanley J

“…Early identification of chemotherapy-refractory lymphoma patients provides a basis for alternative treatment strategies. Metabolic imaging with (18)F-FDG PET…”
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The efficacy and safety of B‐cell depletion with anti‐CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura by Cooper, Nichola, Stasi, Roberto, Cunningham‐Rundles, Susanna, Feuerstein, Michael A., Leonard, John P., Amadori, Sergio, Bussel, James B.

“…Summary Because of its B‐cell depleting effect, rituximab has entered clinical trials in several autoimmune conditions. This study assesses the efficacy and…”
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pH Responsive Eu(III)−Phenanthroline Supramolecular Conjugate:  Novel “Off − On − Off” Luminescent Signaling in the Physiological pH Range by Gunnlaugsson, Thorfinnur, Leonard, Joseph P, Sénéchal, Katell, Harte, Andrew J

“…The formation of luminescent supramolecular ternary complexes in water:  delayed luminescence sensing of aromatic carboxylates using coordinated unsaturated…”
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Tositumomab and Iodine-131 Tositumomab Produces Durable Complete Remissions in a Subset of Heavily Pretreated Patients With Low-Grade and Transformed Non-Hodgkin’s Lymphomas by FISHER, Richard I, KAMINSKI, Mark S, WAHL, Richard L, KNOX, Susan J, ZEIENETZ, Andrew D, VOSE, Julie M, LEONARD, John P, KROLL, Stewart, GOLDSMITH, Stanley J, COLEMAN, Morton

“…This study is an integrated efficacy analysis of the five clinical trials of tositumomab and iodine-131 tositumomab in patients with relapsed or refractory…”
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A phase I/II study of galiximab (an anti-CD80 monoclonal antibody) in combination with rituximab for relapsed or refractory, follicular lymphoma by Leonard, JP, Friedberg, JW, Younes, A, Fisher, D, Gordon, LI, Moore, J, Czuczman, M, Miller, T, Stiff, P, Cheson, BD, Forero-Torres, A, Chieffo, N, McKinney, B, Finucane, D, Molina, A

“…Background: Galiximab is a monoclonal antibody that targets CD80, a costimulatory molecule constitutively expressed on follicular and other lymphomas. Modest…”
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Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties by Carnahan, Josette, Wang, Paul, Kendall, Richard, Chen, Ching, Hu, Sylvia, Boone, Tom, Juan, Todd, Talvenheimo, Jane, Montestruque, Silvia, Sun, Jilin, Elliott, Gary, Thomas, John, Ferbas, John, Kern, Brent, Briddell, Robert, Leonard, John P, Cesano, Alessandra

“…Epratuzumab is a novel humanized antihuman CD22 IgG1 antibody that has recently shown promising clinical activity, both as a single agent and in combination…”
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Epratuzumab, a humanized anti-CD22 antibody, in aggressive non-Hodgkin's lymphoma: Phase I/II clinical trial results by LEONARD, John P, COLEMAN, Morton, HANSEN, Hans J, ZICCARDI, Heather, ESCHENBERG, Michael, GAYKO, Urte, FIELDS, Scott Z, CESANO, Alessandra, GOLDENBERG, David M, KETAS, Jamie C, CHADBURN, Amy, FURMAN, Richard, SCHUSTER, Michael W, FELDMAN, Eric J, ASHE, Michelle, SCHUSTER, Stephen J, WEGENER, William A

“…We conducted a single-center, dose-escalation study evaluating the safety, pharmacokinetics, and efficacy of epratuzumab, an anti-CD22 humanized monoclonal…”
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Abbreviated Chemotherapy With Fludarabine Followed by Tositumomab and Iodine I 131 Tositumomab for Untreated Follicular Lymphoma by LEONARD, John P, COLEMAN, Morton, KROLL, Stewart, TIDMARSH, George, VALLABHAJOSULA, Shankar, GOLDSMITH, Stanley J, KOSTAKOGLU, Lale, CHADBURN, Amy, CESARMAN, Ethel, FURMAN, Richard R, SCHUSTER, Michael W, NIESVIZKY, Ruben, MUSS, Daniel, FIORE, Jennifer

“…To evaluate the safety and efficacy of a sequential chemotherapy plus radioimmunotherapy (RIT) regimen in previously untreated follicular non-Hodgkin's…”
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Combination Antibody Therapy With Epratuzumab and Rituximab in Relapsed or Refractory Non-Hodgkin's Lymphoma by LEONARD, John P, COLEMAN, Morton, KOVACS, Jacqueline, DING, Cliff L, WEGENER, William A, HORAK, Ivan D, GOLDENBERG, David M, KETAS, Jamie, ASHE, Michelle, FIORE, Jennifer M, FURMAN, Richard R, NIESVIZKY, Ruben, SHORE, Tsiporah, CHADBURN, Amy, HOME, Heather

“…To explore the safety and therapeutic activity of combination anti-B-cell monoclonal antibody therapy in non-Hodgkin's lymphoma (NHL). Twenty-three patients…”
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Phase I/II Trial of Epratuzumab (Humanized Anti-CD22 Antibody) in Indolent Non-Hodgkin’s Lymphoma by LEONARD, John P, COLEMAN, Morton, GAYKO, Urte, CESANO, Alessandra, GOLDENBERG, David M, KETAS, Jamie C, CHADBURN, Amy, ELY, Scott, FURMAN, Richard R, WEGENER, William A, HANSEN, Hans J, ZICCARDI, Heather, ESCHENBERG, Michael

“…This single-center, dose-escalation study examines the safety, efficacy, and pharmacokinetics of epratuzumab (anti-CD22 humanized monoclonal antibody) in…”
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Delayed lanthanide luminescence sensing of aromatic carboxylates using heptadentate triamide Tb(III) cyclen complexes: the recognition of salicylic acid in water by Gunnlaugsson, Thorfinnur, Harte, Andrew J, Leonard, Joseph P, Nieuwenhuyzen, Mark

“…The coordinately unsaturated terbium complexes Tb.1 and Tb.2 possess two labile metal-bound water molecules that can be displaced upon metal chelation to…”
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Comparison of fluorine‐18 fluorodeoxyglucose positron emission tomography and Ga‐67 scintigraphy in evaluation of lymphoma by Kostakoglu, Lale, Leonard, John P., Kuji, Ichiei, Coleman, Morton, Vallabhajosula, Shankar, Goldsmith, Stanley J.

“…BACKGROUND The accuracy of fluorodeoxyglucose positron emission tomography (FDG‐PET; dual‐head camera with attenuation correction) and Ga‐67 scintigraphy was…”
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Phase I/II Study of Galiximab, an Anti-CD80 Antibody, for Relapsed or Refractory Follicular Lymphoma by CZUCZMAN, Myron S, THALL, Aron, SWEETENHAM, John, ALKUZWENY, Baha, FINUCANE, Deborah M, LEIGH, Bryan R, WITZIG, Thomas E, VASE, Julie M, YOUNES, Anas, EMMANOUILIDES, Christos, MILLER, Thomas P, MOORE, Joseph O, LEONARD, John P, GORDON, Leo I

“…This multicenter, dose-escalation study evaluates the safety, pharmacokinetics, and efficacy of galiximab (anti-CD80 monoclonal antibody) in patients with…”
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Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis by Marusic, Suzana, Leach, Michael W, Pelker, Jeffrey W, Azoitei, Mihai L, Uozumi, Naonori, Cui, Junqing, Shen, Marina W H, DeClercq, Charlene M, Miyashiro, Joy S, Carito, Brenda A, Thakker, Paresh, Simmons, David L, Leonard, John P, Shimizu, Takao, Clark, James D

“…Experimental autoimmune encephalomyelitis (EAE), a Th1-mediated inflammatory disease of the central nervous system (CNS), is a model of human multiple…”
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The Radioisotope Contributes Significantly to the Activity of Radioimmunotherapy by DAVIS, Thomas A, KAMINSKI, Mark S, LEVY, Ronald, KNOX, Susan J, LEONARD, John P, HSU, Frank J, WILKINSON, Mary, ZELENETZ, Andrew, WAHL, Richard L, KROLL, Stewart, COLEMAN, Morton, GORIS, Michael

“…Purpose: A multicenter, randomized study was undertaken to estimate the single agent activity of Tositumomab and to determine the contribution of…”
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Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin by Leonard, JP, Quinto, CM, Kozitza, MK, Neben, TY, Goldman, SJ

“…Interleukin-11 (IL-11) is a novel multifunctional hematopoietic cytokine capable of stimulating cells of the myeloid, lymphoid, erythroid, and megakaryocytic…”
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Lanthanide luminescent switches: modulation of the luminescence of bis-macrocyclic based Tb(III) conjugates in water by H+, Na+ and K by Gunnlaugsson, Thorfinnur, Leonard, Joseph P

“…The synthesis of four bis-macrocyclic conjugates made from the coupling of either diaza-15-crown-5 ethers (1 and 3) and diaza-18-crown-6 ethers (2 and 4) to…”
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