Search Results - "Leonard, I"

A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish by Ablain, Julien, Durand, Ellen M., Yang, Song, Zhou, Yi, Zon, Leonard I.

“…CRISPR/Cas9 technology of genome editing has greatly facilitated the targeted inactivation of genes in vitro and in vivo in a wide range of organisms. In…”
Get full text

Hematopoiesis by Jagannathan-Bogdan, Madhumita, Zon, Leonard I

“…Hematopoiesis - the process by which blood cells are formed - has been studied intensely for over a century using a variety of model systems. There is…”
Get full text

Hooked! Modeling human disease in zebrafish by Santoriello, Cristina, Zon, Leonard I

“…Zebrafish have been widely used as a model system for studying developmental processes, but in the last decade, they have also emerged as a valuable system for…”
Get full text

Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal by Zon, Leonard I

“…When stem cells divide, they can generate progeny with the same developmental potential as the original cell, a process referred to as self-renewal…”
Get full text

Use of Zebrafish in Drug Discovery Toxicology by Cassar, Steven, Adatto, Isaac, Freeman, Jennifer L, Gamse, Joshua T, Iturria, Iñaki, Lawrence, Christian, Muriana, Arantza, Peterson, Randall T, Van Cruchten, Steven, Zon, Leonard I

“…Unpredicted human safety events in clinical trials for new drugs are costly in terms of human health and money. The drug discovery industry attempts to…”
Get full text

Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials by Patton, E. Elizabeth, Zon, Leonard I., Langenau, David M.

“…Numerous drug treatments that have recently entered the clinic or clinical trials have their genesis in zebrafish. Zebrafish are well established for their…”
Get full text

Clonal hematopoiesis and inflammation – the perpetual cycle by Avagyan, Serine, Zon, Leonard I.

“…Clonal hematopoiesis (CH) is associated with elevated pro-inflammatory cytokines which act as a driving force for clonal expansion.Recurrent or chronic…”
Get full text

Isotopic evidence for widespread cold‐season‐biased groundwater recharge and young streamflow across central Canada by Jasechko, Scott, Wassenaar, Leonard I., Mayer, Bernhard

“…Transformations of precipitation into groundwater and streamflow are fundamental hydrological processes, critical to irrigated agriculture, hydroelectric power…”
Get full text

Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche by Tamplin, Owen J., Durand, Ellen M., Carr, Logan A., Childs, Sarah J., Hagedorn, Elliott J., Li, Pulin, Yzaguirre, Amanda D., Speck, Nancy A., Zon, Leonard I.

“…Hematopoietic stem and progenitor cells (HSPCs) can reconstitute and sustain the entire blood system. We generated a highly specific transgenic reporter of…”
Get full text

Zebrafish patient avatars in cancer biology and precision cancer therapy by Fazio, Maurizio, Ablain, Julien, Chuan, Yan, Langenau, David M., Zon, Leonard I.

“…In precision oncology, two major strategies are being pursued for predicting clinically relevant tumour behaviours, such as treatment response and emergence of…”
Get full text

Role of RNA modifications in blood development and regeneration by Gunage, Rajesh, Zon, Leonard I.

“…Blood development and regeneration require rapid turnover of cells, and ribonucleic acid (RNA) modifications play a key role in it via regulating stemness and…”
Get full text

Of fish and men: using zebrafish to fight human diseases by Ablain, Julien, Zon, Leonard I

“…Long restricted to the field of developmental biology, the use of the zebrafish ( Danio rerio ) has extended to the study of human pathogenesis. Fostered by…”
Get full text

The dark side of PD-1 receptor inhibition by Ludin, Aya, Zon, Leonard I.

“…Inhibiting the protein PD-1 can activate T cells that trigger immune responses against tumour cells. But it emerges that, in mice, this immunotherapy…”
Get full text

Stable isotopes in global lakes integrate catchment and climatic controls on evaporation by Vystavna, Yuliya, Harjung, Astrid, Monteiro, Lucilena R., Matiatos, Ioannis, Wassenaar, Leonard I.

“…Global warming is considered a major threat to Earth’s lakes water budgets and quality. However, flow regulation, over-exploitation, lack of hydrological data,…”
Get full text

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells by Zhang, Bing, Ma, Sai, Rachmin, Inbal, He, Megan, Baral, Pankaj, Choi, Sekyu, Gonçalves, William A., Shwartz, Yulia, Fast, Eva M., Su, Yiqun, Zon, Leonard I., Regev, Aviv, Buenrostro, Jason D., Cunha, Thiago M., Chiu, Isaac M., Fisher, David E., Hsu, Ya-Chieh

“…Empirical and anecdotal evidence has associated stress with accelerated hair greying (formation of unpigmented hairs) 1 , 2 , but so far there has been little…”
Get full text

Assessing the performance of international laboratories analysing the stable isotope composition ( δ 15 N, δ 18 O, δ 17 O) of nitrate in environmental waters by Wassenaar, Leonard I., Douence, Cedric, Miller, Jodie

“…Rationale Stable‐isotope analyses of nitrate (NO 3 − ) in various water sources are crucial for understanding nitrogen pollution and its impact on aquatic…”
Get full text

Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma by Lian, Christine Guo, Xu, Yufei, Ceol, Craig, Wu, Feizhen, Larson, Allison, Dresser, Karen, Xu, Wenqi, Tan, Li, Hu, Yeguang, Zhan, Qian, Lee, Chung-wei, Hu, Di, Lian, Bill Q., Kleffel, Sonja, Yang, Yijun, Neiswender, James, Khorasani, Abraham J., Fang, Rui, Lezcano, Cecilia, Duncan, Lyn M., Scolyer, Richard A., Thompson, John F., Kakavand, Hojabr, Houvras, Yariv, Zon, Leonard I., Mihm, Martin C., Kaiser, Ursula B., Schatton, Tobias, Woda, Bruce A., Murphy, George F., Shi, Yujiang G.

“…DNA methylation at the 5 position of cytosine (5-mC) is a key epigenetic mark that is critical for various biological and pathological processes. 5-mC can be…”
Get full text

Cancer immunotherapy: The dark side of PD-1 receptor inhibition by Ludin, Aya, Zon, Leonard I

Get full text

Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors by Doulatov, Sergei, Vo, Linda T., Chou, Stephanie S., Kim, Peter G., Arora, Natasha, Li, Hu, Hadland, Brandon K., Bernstein, Irwin D., Collins, James J., Zon, Leonard I., Daley, George Q.

“…Human pluripotent stem cells (hPSCs) represent a promising source of patient-specific cells for disease modeling, drug screens, and cellular therapies…”
Get full text

Colorimetric Barcoding to Track, Isolate, and Analyze Hematopoietic Stem Cell Clones by Bornhorst, Dorothee, Gheller, Brandon, Zon, Leonard I

“…In zebrafish, hematopoietic stem cells (HSCs) are born in the developing aorta during embryogenesis. From the definitive wave of hematopoiesis onward, blood…”
Get more information