Search Results - "Leonard, Alexander"

Novel functional sequences uncovered through a bovine multiassembly graph by Crysnanto, Danang, Leonard, Alexander S., Fang, Zih-Hua, Pausch, Hubert

“…Many genomic analyses start by aligning sequencing reads to a linear reference genome. However, linear reference genomes are imperfect, lacking millions of…”
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Charge-state lifetimes of single molecules on few monolayers of NaCl by Kaiser, Katharina, Lieske, Leonard-Alexander, Repp, Jascha, Gross, Leo

“…In molecular tunnel junctions, where the molecule is decoupled from the electrodes by few-monolayers-thin insulating layers, resonant charge transport takes…”
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Pangenome-genotyped structural variation improves molecular phenotype mapping in cattle by Leonard, Alexander S, Mapel, Xena M, Pausch, Hubert

“…Expression and splicing quantitative trait loci (e/sQTL) are large contributors to phenotypic variability. Achieving sufficient statistical power for e/sQTL…”
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Molecular quantitative trait loci in reproductive tissues impact male fertility in cattle by Mapel, Xena Marie, Kadri, Naveen Kumar, Leonard, Alexander S., He, Qiongyu, Lloret-Villas, Audald, Bhati, Meenu, Hiltpold, Maya, Pausch, Hubert

“…Breeding bulls are well suited to investigate inherited variation in male fertility because they are genotyped and their reproductive success is monitored…”
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RNA-DNA differences in variant calls from cattle tissues result in erroneous eQTLs by Leonard, Alexander S, Mapel, Xena M, Pausch, Hubert

“…Association testing between molecular phenotypes and genomic variants can help to understand how genotype affects phenotype. RNA sequencing provides access to…”
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Graph construction method impacts variation representation and analyses in a bovine super-pangenome by Leonard, Alexander S, Crysnanto, Danang, Mapel, Xena M, Bhati, Meenu, Pausch, Hubert

“…Several models and algorithms have been proposed to build pangenomes from multiple input assemblies, but their impact on variant representation, and…”
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The size and composition of haplotype reference panels impact the accuracy of imputation from low-pass sequencing in cattle by Lloret-Villas, Audald, Pausch, Hubert, Leonard, Alexander S

“…Low-pass sequencing followed by sequence variant genotype imputation is an alternative to the routine microarray-based genotyping in cattle. However, the…”
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Comment on Brandl et al. Immediate Effects of Myofascial Release on the Thoracolumbar Fascia and Osteopathic Treatment for Acute Low Back Pain on Spine Shape Parameters: A Randomized, Placebo-Controlled Trial. Life 2021, 11, 845 by Kudus, Alexander Leonard

“…I want to congratulate Brandl et al. [...]…”
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Author Correction: Charge-state lifetimes of single molecules on few monolayers of NaCl by Kaiser, Katharina, Lieske, Leonard-Alexander, Repp, Jascha, Gross, Leo

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Evolution of interface binding strengths in simplified model of protein quaternary structure by Leonard, Alexander S, Ahnert, Sebastian E

“…The self-assembly of proteins into protein quaternary structures is of fundamental importance to many biological processes, and protein misassembly is…”
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Exploiting public databases of genomic variation to quantify evolutionary constraint on the branch point sequence in 30 plant and animal species by Nosková, Adéla, Li, Chao, Wang, Xiaolong, Leonard, Alexander S, Pausch, Hubert, Kadri, Naveen Kumar

“…Abstract The branch point sequence is a degenerate intronic heptamer required for the assembly of the spliceosome during pre-mRNA splicing. Disruption of this…”
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Bistability between π-diradical open-shell and closed-shell states in indeno[1,2-a]fluorene by Mishra, Shantanu, Vilas-Varela, Manuel, Lieske, Leonard-Alexander, Ortiz, Ricardo, Fatayer, Shadi, Rončević, Igor, Albrecht, Florian, Frederiksen, Thomas, Peña, Diego, Gross, Leo

“…Indenofluorenes are non-benzenoid conjugated hydrocarbons that have received great interest owing to their unusual electronic structure and potential…”
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Portraits of Soot Molecules Reveal Pathways to Large Aromatics, Five-/Seven-Membered Rings, and Inception through π‑Radical Localization by Lieske, Leonard-Alexander, Commodo, Mario, Martin, Jacob W., Kaiser, Katharina, Benekou, Vasiliki, Minutolo, Patrizia, D’Anna, Andrea, Gross, Leo

“…Incipient soot early in the flame was studied by high-resolution atomic force microscopy and scanning tunneling microscopy to resolve the atomic structure and…”
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Structural variant-based pangenome construction has low sensitivity to variability of haplotype-resolved bovine assemblies by Leonard, Alexander S., Crysnanto, Danang, Fang, Zih-Hua, Heaton, Michael P., Vander Ley, Brian L., Herrera, Carolina, Bollwein, Heinrich, Bickhart, Derek M., Kuhn, Kristen L., Smith, Timothy P. L., Rosen, Benjamin D., Pausch, Hubert

“…Advantages of pangenomes over linear reference assemblies for genome research have recently been established. However, potential effects of sequence platform…”
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Author Correction: Molecular quantitative trait loci in reproductive tissues impact male fertility in cattle by Mapel, Xena Marie, Kadri, Naveen Kumar, Leonard, Alexander S., He, Qiongyu, Lloret-Villas, Audald, Bhati, Meenu, Hiltpold, Maya, Pausch, Hubert

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Introducing Ultra-Low Energy Ion Implantation of Radioactive Isotopes at ISOLDE, CERN for (Near-)Surface Characterization: The ASPIC and ASCII Vacuum Chambers by van Stiphout, Koen, Lieske, Leonard-Alexander, Auge, Manuel, Hofsäss, Hans

“…Solid-state physics research has long employed radioactive isotopes to investigate the crystallographic, electric and magnetic properties of nanostructures…”
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“Use the Force!” Adaptation of Response Formats: From Rating Scale to Multidimensional Forced Choice by Schünemann, Alexander Leonard, Ziegler, Matthias

“…The present paper features the adaptation of an existing Big Five questionnaire with a rating scale (RS) response format into a measure using a…”
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Structural variation and introgression from wild populations in East Asian cattle genomes confer adaptation to local environment by Xia, Xiaoting, Zhang, Fengwei, Li, Shuang, Luo, Xiaoyu, Peng, Lixin, Dong, Zheng, Pausch, Hubert, Leonard, Alexander S, Crysnanto, Danang, Wang, Shikang, Tong, Bin, Lenstra, Johannes A, Han, Jianlin, Li, Fuyong, Xu, Tieshan, Gu, Lihong, Jin, Liangliang, Dang, Ruihua, Huang, Yongzhen, Lan, Xianyong, Ren, Gang, Wang, Yu, Gao, Yuanpeng, Ma, Zhijie, Cheng, Haijian, Ma, Yun, Chen, Hong, Pang, Weijun, Lei, Chuzhao, Chen, Ningbo

“…Structural variations (SVs) in individual genomes are major determinants of complex traits, including adaptability to environmental variables. The Mongolian…”
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Markhor-derived Introgression of a Genomic Region Encompassing PAPSS2 Confers High-altitude Adaptability in Tibetan Goats by Li, Chao, Wu, Yujiang, Chen, Bingchun, Cai, Yudong, Guo, Jiazhong, Leonard, Alexander S, Kalds, Peter, Zhou, Shiwei, Zhang, Jingchen, Zhou, Ping, Gan, Shangqu, Jia, Ting, Pu, Tianchun, Suo, Langda, Li, Yan, Zhang, Ke, Li, Lan, Purevdorj, Myagmarsuren, Wang, Xihong, Li, Ming, Wang, Yu, Liu, Yao, Huang, Shuhong, Sonstegard, Tad, Wang, Ming-Shan, Kemp, Stephen, Pausch, Hubert, Chen, Yulin, Han, Jian-Lin, Jiang, Yu, Wang, Xiaolong

“…Understanding the genetic mechanism of how animals adapt to extreme conditions is fundamental to determine the relationship between molecular evolution and…”
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Recent selection and introgression facilitated high-altitude adaptation in cattle by Lyu, Yang, Wang, Fuwen, Cheng, Haijian, Han, Jing, Dang, Ruihua, Xia, Xiaoting, Wang, Hui, Zhong, Jincheng, Lenstra, Johannes A., Zhang, Hucai, Han, Jianlin, MacHugh, David E., Medugorac, Ivica, Upadhyay, Maulik, Leonard, Alexander S., Ding, He, Yang, Xiaorui, Wang, Ming-Shan, Quji, Suolang, Zhuzha, Basang, Quzhen, Pubu, Wangmu, Silang, Cangjue, Nima, Wa, Da, Ma, Weidong, Liu, Jianyong, Zhang, Jicai, Huang, Bizhi, Qi, Xingshan, Li, Fuqiang, Huang, Yongzhen, Ma, Yun, Wang, Yu, Gao, Yuanpeng, Lu, Wenfa, Lei, Chuzhao, Chen, Ningbo

“…[Display omitted] During the past 3000 years, cattle on the Qinghai-Xizang Plateau have developed adaptive phenotypes under the selective pressure of hypoxia,…”
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