Addressing Challenges in Standardizing Helicobacter pylori Treatment Protocols: Importance and Review

, one of the top carcinogens, is associated with most cases of gastric cancer-related deaths worldwide. Over the past two decades, the rising rates of antibiotic resistance in the bacterium have reduced the efficacy of conventional antibiotic-based treatments. This underscores the urgency for contin...

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Bibliographic Details
Published in:	Curēus (Palo Alto, CA) Vol. 16; no. 4; p. e59394
Main Authors:	Kaur, Ranjot, Leon Guevara, Carlos
Format:	Journal Article
Language:	English
Published:	United States Cureus Inc 30-04-2024 Cureus
Subjects:	Antibiotics Bacterial infections Clinical practice guidelines Drug resistance Gastric cancer Gastroenterology Gastrointestinal diseases Patient compliance Quality Improvement Therapeutics helicobacter pylori helicobacter pylori infection treatment covid-19 disease patient compliance bacteria gastric cancer antibiotic resistance neem
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Summary:	, one of the top carcinogens, is associated with most cases of gastric cancer-related deaths worldwide. Over the past two decades, the rising rates of antibiotic resistance in the bacterium have reduced the efficacy of conventional antibiotic-based treatments. This underscores the urgency for continued research and novel treatment approaches. Establishing a worldwide accepted physician guideline for antibiotic prescription is crucial to combat antibiotic resistance and improve infection management. Therefore, it is important to address the challenges that complicate the establishment of a universally accepted treatment protocol to prescribe an antibiotic regimen to eradicate . The answers to the questions of why conventional standard triple therapy remains a first-line treatment choice despite its low efficacy, and how different factors affect therapy choice, are needed to identify these challenges. Hence, this review addresses concerns related to treatment choice, role of antibiotic resistance and patient compliance in treatment outcomes, first-line vs. second-line therapy options, and methods for enhancing existing treatment methods. We also present a chart to aid antibiotic treatment prescription, which may support physician guidelines in this aspect. Eradication of and patient adherence is paramount in overcoming antibiotic resistance in the bacterium, and our chart summarizes key considerations and suggests novel approaches to achieve this goal.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	2168-8184 2168-8184
DOI:	10.7759/cureus.59394