Search Results - "Leon, Leonardo"

BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation by Lampert, Mark A., Orogo, Amabel M., Najor, Rita H., Hammerling, Babette C., Leon, Leonardo J., Wang, Bingyan J., Kim, Taeyong, Sussman, Mark A., Gustafsson, Åsa B.

“…Cell-based therapies represent a very promising strategy to repair and regenerate the injured heart to prevent progression to heart failure. To date, these…”
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Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired by Liang, Wenjing, Sagar, Shakti, Ravindran, Rishith, Najor, Rita H., Quiles, Justin M., Chi, Liguo, Diao, Rachel Y., Woodall, Benjamin P., Leon, Leonardo J., Zumaya, Erika, Duran, Jason, Cauvi, David M., De Maio, Antonio, Adler, Eric D., Gustafsson, Åsa B.

“…Mitochondrial quality control is critical for cardiac homeostasis as these organelles are responsible for generating most of the energy needed to sustain…”
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Staying young at heart: autophagy and adaptation to cardiac aging by Leon, Leonardo J, Gustafsson, Åsa B

“…Abstract Aging is a predominant risk factor for developing cardiovascular disease. Therefore, the cellular processes that contribute to aging are attractive…”
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A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance by Hammerling, Babette C., Najor, Rita H., Cortez, Melissa Q., Shires, Sarah E., Leon, Leonardo J., Gonzalez, Eileen R., Boassa, Daniela, Phan, Sébastien, Thor, Andrea, Jimenez, Rebecca E., Li, Hong, Kitsis, Richard N., Dorn, Gerald W., Sadoshima, Junichi, Ellisman, Mark H., Gustafsson, Åsa B.

“…Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal. The currently recognized mechanism for disposal of mitochondria is…”
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Devices and control strategies for voltage regulation under influence of photovoltaic distributed generation. A review by Leon, Leonardo F., Martinez, Maximiliano, Ontiveros, Leonardo J., Mercado, Pedro E.

“…Photovoltaic Distributed Generation (PV-DG) produces some technical, commercial, and regulatory challenges in distribution systems. The most important…”
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Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise by Moyzis, Alexandra G., Lally, Navraj S., Liang, Wenjing, Leon, Leonardo J., Najor, Rita H., Orogo, Amabel M., Gustafsson, Åsa B.

“…Myeloid cell leukemia-1 (Mcl-1) is a structurally and functionally unique anti-apoptotic Bcl-2 protein. While elevated levels of Mcl-1 contribute to tumor cell…”
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A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells by Leon, Leonardo J, Pasupuleti, Nagarekha, Gorin, Fredric, Carraway, 3rd, Kermit L

“…Amiloride is a potassium-sparing diuretic that has been used as an anti-kaliuretic for the chronic management of hypertension and heart failure. Several…”
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Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy by Zhu, Siting, Chen, Ze’e, Zhu, Mason, Shen, Ying, Leon, Leonardo J., Chi, Liguo, Spinozzi, Simone, Tan, Changming, Gu, Yusu, Nguyen, Anh, Zhou, Yi, Feng, Wei, Vaz, Frédéric M., Wang, Xiaohong, Gustafsson, Asa B., Evans, Sylvia M., Kunfu, Ouyang, Fang, Xi

“…Cardiomyopathy is a major clinical feature in Barth syndrome (BTHS), an X-linked mitochondrial lipid disorder caused by mutations in ( ), encoding a…”
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Nuclear Parkin Activates the ERRα Transcriptional Program and Drives Widespread Changes in Gene Expression Following Hypoxia by Shires, Sarah E., Quiles, Justin M., Najor, Rita H., Leon, Leonardo J., Cortez, Melissa Q., Lampert, Mark A., Mark, Adam, Gustafsson, Åsa B.

“…Parkin is an E3 ubiquitin ligase well-known for facilitating clearance of damaged mitochondria by ubiquitinating proteins on the outer mitochondrial membrane…”
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Prognostic factors for recurrence in patients with papillary thyroid carcinoma by Hakim Tawil, José Antonio, Rojas, María Fernanda, Santivañez, Juan José, León, Leonardo, González Devia, Deyanira

“…The prognostic factors for tumor recurrence and mortality of patients diagnosed with Papillary Thyroid Carcinoma (PTC) with immediate surgery in Colombia has…”
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Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin by Hammerling, Babette C, Shires, Sarah E, Leon, Leonardo J, Cortez, Melissa Q, Gustafsson, Åsa B

“…Degradation of mitochondria is an important cellular quality control mechanism mediated by two distinct pathways: one involving Parkin-mediated ubiquitination…”
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Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells by Rowson-Hodel, Ashley R, Berg, Anastasia L, Wald, Jessica H, Hatakeyama, Jason, VanderVorst, Kacey, Curiel, Daniel A, Leon, Leonardo J, Sweeney, Colleen, Carraway, Kermit L

“…Highlights • Hexamethylene amiloride (HMA) selectively kills breast cancer cells relative to non-transformed cells. • HMA is cytotoxic to breast cancer cells…”
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4-(5-Benzyl-3-((4-fluorophenyl)sulfonyl)-5-methyl-4,5-dihydrofuran-2-yl)-2-nitrobenzamide by Avendaño Leon, Oscar Leonardo, Curti, Christophe, El-Kashef, Hussein, Kabri, Youssef, Redon, Sébastien, Vanelle, Patrice

“…As part of our ongoing attempt to broaden the applications of the amidoxime moiety as a potential source of new antileishmanial agents, this study focuses on…”
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The cellular and humoral immune response to influenza vaccination is comparable in asthmatic and healthy subjects by Velasco-Medina, Andrea Aida, García-León, Miguel Leonardo, Velázquez-Sámano, Guillermo, Wong-Chew, Rosa María

“…Annual influenza vaccination is recommended as a preventive measure for all patients with asthma since asthma exacerbations in children and adults are…”
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Factors Associated With SARS-CoV-2 Infection in Bogotá, Colombia: Results From a Large Epidemiological Surveillance Study by Varela, Andrea Ramirez, Florez, Luis Jorge Hernandez, Tamayo-Cabeza, Guillermo, Contreras-Arrieta, Sandra, Restrepo, Silvia Restrepo, Laajaj, Rachid, Gutierrez, Giancarlo Buitrago, Guevara, Yenny Paola Rueda, Caballero-Díaz, Yuldor, Florez, Martha Vives, Osorio, Elkin, Barbieri, Ignacio Sarmiento, Sanchez, Daniela Rodriguez, Nuñez, Leonardo Leon, Bernal, Raquel, Oliveros, Sofía Rios, Zapata, Leonardo Salas, Guevara-Suarez, Marcela, Uribe, Alejandro Gaviria, Behrentz, Eduardo

“…Epidemiologic surveillance of COVID-19 is essential to collect and analyse data to improve public health decision making during the pandemic. There are few…”
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Diethyl (5-Benzyl-2-(4-(N′-hydroxycarbamimidoyl)phenyl)-5-methyl-4,5-dihydrofuran-3-yl)phosphonate by Avendaño Leon, Oscar Leonardo, Curti, Christophe, Santos Urbancg Moncorvo, Fabiana Maia, Kabri, Youssef, Redon, Sébastien, Torres-Santos, Eduardo Caio, Paoli-Lombardo, Romain, Vanelle, Patrice

“…As part of our ongoing research into the antileishmanial properties of amidoxime derivatives, we report a preliminary assessment of the antiparasitic…”
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Studying World Heritage visitors: the case of Cuenca, Ecuador by Lopez-Guzman, Tomas, Pérez Gálvez, Jesús Claudio, Muñoz Fernández, Guzmán Antonio, Leonardo Torres León

“…PurposeThe purpose of this paper is to explore the existing relations between three fundamental constructs (motivation and satisfaction) and the type of…”
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Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening by Wu, Chun-Yi, Wang, Don-Hong, Wang, Xiaobing, Dixon, Seth M, Meng, Liping, Ahadi, Sara, Enter, Daniel H, Chen, Chao-Yu, Kato, Jason, Leon, Leonardo J, Ramirez, Laura M, Maeda, Yoshiko, Reis, Carolina F, Ribeiro, Brianna, Weems, Brittany, Kung, Hsing-Jien, Lam, Kit S

“…Identifying “druggable” targets and their corresponding therapeutic agents are two fundamental challenges in drug discovery research. The one-bead-one-compound…”
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Ion exchange membranes are sensitive indicators of ammonium and nitrate released from green manures with low C/N ratios by Castro, Leonardo León, Whalen, Joann K.

“…Green manure is a valuable nitrogen (N) source, but must undergo decomposition, mineralization and nitrification to release mineral N (NH4-N and NO3-N). The…”
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Sujetos intersexuales y matriz heterosexual: Los cuerpos que le importan a la jurisprudencia colombiana; Una lectura queer by Leon, Javier Enrique Garcia, Leon, David Leonardo Garcia

“…Este artículo presenta los resultados de una investigación que analiza la sentencia T-622/14 de la Corte Constitucional Colombiana en torno a la reasignación…”
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