Search Results - "Leon, Kelly E."

ATM inhibition drives metabolic adaptation via induction of macropinocytosis by Huang, Zhentai, Chen, Chi-Wei, Buj, Raquel, Tangudu, Naveen Kumar, Fang, Richard S, Leon, Kelly E, Dahl, Erika S, Varner, Erika L, von Krusenstiern, Eliana, Cole, Aidan R, Snyder, Nathaniel W, Aird, Katherine M

“…Macropinocytosis is a nonspecific endocytic process that may enhance cancer cell survival under nutrient-poor conditions. Ataxia-Telangiectasia mutated (ATM)…”
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Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming by Buj, Raquel, Chen, Chi-Wei, Dahl, Erika S., Leon, Kelly E., Kuskovsky, Rostislav, Maglakelidze, Natella, Navaratnarajah, Maithili, Zhang, Gao, Doan, Mary T., Jiang, Helen, Zaleski, Michael, Kutzler, Lydia, Lacko, Holly, Lu, Yiling, Mills, Gordon B., Gowda, Raghavendra, Robertson, Gavin P., Warrick, Joshua I., Herlyn, Meenhard, Imamura, Yuka, Kimball, Scot R., DeGraff, David J., Snyder, Nathaniel W., Aird, Katherine M.

“…Reprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a cell cycle inhibitor and tumor suppressor that is upregulated during…”
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Loss of p16: A Bouncer of the Immunological Surveillance? by Leon, Kelly E, Tangudu, Naveen Kumar, Aird, Katherine M, Buj, Raquel

“…p16 (hereafter called p16) is an important tumor suppressor protein frequently suppressed in human cancer and highly upregulated in many types of senescence…”
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GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment by Worley, Beth L., Kim, Yeon Soo, Mardini, Jennifer, Zaman, Rameez, Leon, Kelly E., Vallur, Piyushi Gupta, Nduwumwami, Asvelt, Warrick, Joshua I., Timmins, Patrick F., Kesterson, Joshua P., Phaëton, Rébécca, Lee, Nam Y., Walter, Vonn, Endres, Lauren, Mythreye, Karthikeyan, Aird, Katherine M., Hempel, Nadine

“…Ovarian cancer remains the most lethal gynecologic malignancy, and is primarily diagnosed at late stage when considerable metastasis has occurred in the…”
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Jumonji C Demethylases in Cellular Senescence by Leon, Kelly E, Aird, Katherine M

“…Senescence is a stable cell cycle arrest that is either tumor suppressive or tumor promoting depending on context. Epigenetic changes such as histone…”
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The ESCRT-III Protein Chmp1 Regulates Lipid Storage in the Drosophila Fat Body by Fruin, Austin M, Leon, Kelly E, DiAngelo, Justin R

“…Defects in how excess nutrients are stored as triglycerides can result in several diseases including obesity, heart disease, and diabetes. Understanding the…”
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ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells by Chen, Chi-Wei, Buj, Raquel, Dahl, Erika S., Leon, Kelly E., Aird, Katherine M.

“…While therapies targeting deficiencies in the homologous recombination (HR) pathway are emerging as the standard treatment for high grade serous ovarian cancer…”
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Suppression of p16 alleviates the senescence-associated secretory phenotype by Buj, Raquel, Leon, Kelly E, Anguelov, Marlyn A, Aird, Katherine M

“…Oncogene-induced senescence (OIS) is characterized by increased expression of the cell cycle inhibitor p16, leading to a hallmark cell cycle arrest…”
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DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A by Leon, Kelly E, Buj, Raquel, Lesko, Elizabeth, Dahl, Erika S, Chen, Chi-Wei, Tangudu, Naveen Kumar, Imamura-Kawasawa, Yuka, Kossenkov, Andrew V, Hobbs, Ryan P, Aird, Katherine M

“…Oncogene-induced senescence (OIS) is a stable cell cycle arrest that occurs in normal cells upon oncogene activation. Cells undergoing OIS express a wide…”
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Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer by Dahl, Erika S, Buj, Raquel, Leon, Kelly E, Newell, Jordan M, Imamura, Yuka, Bitler, Benjamin G, Snyder, Nathaniel W, Aird, Katherine M

“…Epithelial ovarian cancer (EOC) is the deadliest gynecologic cancer. High-grade serous carcinoma (HGSC) is the most frequently diagnosed and lethal…”
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The regulation of triglyceride storage by ornithine decarboxylase (Odc1) in Drosophila by Leon, Kelly E., Fruin, Austin M., Nowotarski, Shannon L., DiAngelo, Justin R.

“…Polyamines are low molecular weight, organic cations that play a critical role in many major cellular processes including cell cycle regulation and apoptosis,…”
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Suppression of p16 alleviates the senescence-associated secretory phenotype by Buj, Raquel, Leon, Kelly E., Anguelov, Marlyn A., Aird, Katherine M.

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Abstract A38: ATM inhibitor synergizes with glycolysis inhibition in ovarian cancer cells by Chen, Chi-Wei, Dahl, Erika S., Leon, Kelly E., Buj, Raquel, Aird, Katherine M.

“…Epithelial ovarian cancer (EOC) is the deadliest gynecologic malignancy in the USA. While therapies such as inhibitors against poly (ADP-Ribose) polymerase…”
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Abstract A35: Targeting the IDH1-mediated metabolic-epigenetic axis in cyclin E-high ovarian cancer by Dahl, Erika S., Buj, Raquel, Jia, Qingyuan, Leon, Kelly E., Aird, Katherine M.

“…Cyclin E is an oncogene that is overexpressed in approximately 20% of high-grade serous ovarian carcinomas (HGSOC) and is associated with worse survival and…”
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Abstract 1378: Targeting the metabolic-epigenetic axis to sensitize HR-proficient ovarian cancer to PARP inhibitors by Dahl, Erika S., Leon, Kelly E., Chen, Chi-Wei, Jia, Qingyuan, Buj, Raquel, Snyder, Nathaniel W., Aird, Katherine M.

“…Overexpression of the oncogene cyclin E1 is considered one of the initiating factors in fallopian tube transformation and ovarian tumorigenesis. Patients with…”
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The ESCRT-III Protein IChmp1/I Regulates Lipid Storage in the IDrosophila/I Fat Body by Fruin, Austin M, Leon, Kelly E, DiAngelo, Justin R

“…Defects in how excess nutrients are stored as triglycerides can result in several diseases including obesity, heart disease, and diabetes. Understanding the…”
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Targeting IDH1 as a pro-senescent therapy in high-grade serous ovarian cancer by Dahl, Erika S., Buj, Raquel, Leon, Kelly E., Newell, Jordan M., Imamura, Yuka, Bitler, Benjamin G., Snyder, Nathaniel W., Aird, Katherine M.

“…Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer. High-grade serous carcinoma (HGSC) is the most frequently diagnosed and lethal…”
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