Search Results - "Leon, Alejandro Garcia"

Obesity is associated with higher levels of circulating cytokines involved in the development of cardiovascular disease in people living with HIV by Savinelli, Stefano, McGettrick, Pádraig, Garcia Leon, Alejandro A, Tinago, Willard, Haran, Emma, Barco, Elena Alvarez, Landay, Alan L, Mallon, Patrick Wg, Feeney, Eoin R

“…Obesity is increasingly described in people living with HIV (PLWH), but its impact on immune activation and inflammation in HIV is still poorly characterised…”
Get full text

Individuals with obesity who survive SARS‐CoV‐2 infection have preserved antigen‐specific T cell frequencies by Wrigley Kelly, Neil E., Kenny, Grace, Cassidy, Féaron C., Garcia‐Leon, Alejandro A., De Barra, Conor, Mallon, Patrick W. G., Hogan, Andrew E., O'Shea, Donal

“…Objective Obesity is a major risk factor for severe disease in COVID‐19, with increased hospitalization, intensive care unit admission, and mortality. This…”
Get full text

Development of a novel medium throughput flow-cytometry based micro-neutralisation test for SARS-CoV-2 with applications in clinical vaccine trials and antibody screening by O'Reilly, Sophie, Kenny, Grace, Alrawahneh, Tamara, Francois, Nathan, Gu, Lili, Angeliadis, Matthew, de Masson d'Autume, Valentin, Garcia Leon, Alejandro, Feeney, Eoin R, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Horgan, Mary, Mallon, Patrick W. G, Gautier, Virginie

“…Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses generated…”
Get full text

Early inflammatory profiles predict maximal disease severity in COVID-19: An unsupervised cluster analysis by Kenny, Grace, Saini, Gurvin, Gaillard, Colette Marie, Negi, Riya, Alalwan, Dana, Garcia Leon, Alejandro, McCann, Kathleen, Tinago, Willard, Kelly, Christine, Cotter, Aoife G., de Barra, Eoghan, Horgan, Mary, Yousif, Obada, Gautier, Virginie, Landay, Alan, McAuley, Danny, Feeney, Eoin R., O'Kane, Cecilia, Mallon, Patrick WG

“…The inflammatory changes that underlie the heterogeneous presentations of COVID-19 remain incompletely understood. In this study we aimed to identify…”
Get full text

Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time by Kenny, Grace, O’Reilly, Sophie, Wrigley Kelly, Neil, Negi, Riya, Gaillard, Colette, Alalwan, Dana, Saini, Gurvin, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, Garcia Leon, Alejandro Abner, Tinago, Willard, Feeney, Eoin R., Cotter, Aoife G., de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Doran, Peter, Stemler, Jannik, Koehler, Philipp, Cox, Rebecca Jane, O’Shea, Donal, Olesen, Ole F., Landay, Alan, Hogan, Andrew E., Lelievre, Jean-Daniel, Gautier, Virginie, Cornely, Oliver A., Mallon, Patrick W. G.

“…SARS-CoV-2 neutralising antibodies provide protection against COVID-19. Evidence from early vaccine trials suggested binding antibody thresholds could serve as…”
Get full text

Immunogenicity and reactogenicity of a first booster with BNT162b2 or full-dose mRNA-1273: A randomised VACCELERATE trial in adults ≥75 years (EU-COVAT-1) by Neuhann, Julia M., Stemler, Jannik, Carcas, Antonio J., Frías-Iniesta, Jesús, Akova, Murat, Bethe, Ullrich, Heringer, Sarah, Salmanton-García, Jon, Tischmann, Lea, Zarrouk, Marouan, Cüppers, Arnd, Grothe, Jan, Leon, Alejandro Garcia, Mallon, Patrick, Negi, Riya, Gaillard, Colette, Saini, Gurvin, Lammens, Christine, Hotterbeekx, An, Loens, Katherine, Malhotra-Kumar, Surbhi, Goossens, Herman, Kumar-Singh, Samir, König, Franz, Yeghiazaryan, Lusine, Posch, Martin, Koehler, Philipp, Cornely, Oliver A.

“…Vaccination remains crucial for protection against severe SARS-CoV-2 infection, especially for people of advanced age, however, optimal dosing regimens are as…”
Get full text

Robust and persistent B-cell responses following SARS-CoV-2 vaccine determine protection from SARS-CoV-2 infection by Byrne, Joanne, Gu, Lili, Garcia-Leon, Alejandro, Gaillard, Colette Marie, Saini, Gurvin, Alalwan, Dana, Tomás-Cortázar, Julen, Kenny, Grace, Donohue, Sean, Reynolds, Bearach, O'Gorman, Tessa, Landay, Alan, Doran, Peter, Stemler, Jannik, Koehler, Philipp, Cox, Rebecca Jane, Olesen, Ole F, Lelievre, Jean-Daniel, O'Broin, Cathal, Savinelli, Stefano, Feeney, Eoin R, O'Halloran, Jane A, Cotter, Aoife, Horgan, Mary, Kelly, Christine, Sadlier, Corrina, de Barra, Eoghan, Cornely, Oliver A, Gautier, Virginie, Mallon, Patrick Wg

“…A clear immune correlate of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been defined. We explored antibody,…”
Get full text

Dynamic Change and Clinical Relevance of Postinfectious SARS-CoV-2 Antibody Responses by Mallon, Patrick W G, Tinago, Willard, Leon, Alejandro Garcia, McCann, Kathleen, Kenny, Grace, McGettrick, Padraig, Green, Sandra, Inzitari, Rosanna, Cottere, Aoife G, Feeney, Eoin R, Savinelli, Stefano, Doran, Peter

“…Abstract Background Although reports suggest that most individuals with coronavirus disease 2019 (COVID-19) develop detectable antibodies postinfection, the…”
Get full text

Concordance between PCR-based extraction-free saliva and nasopharyngeal swabs for SARS-CoV-2 testing by De Santi, Chiara, Jacob, Benson, Kroich, Patricia, Doyle, Sean, Ward, Rebecca, Li, Brian, Donnelly, Owain, Dykes, Amy, Neelakant, Trisha, Neary, David, McGuinness, Ross, Cafferkey, Jacqueline, Ryan, Kieran, Quadu, Veronica, McGrogan, Killian, Garcia Leon, Alejandro, Mallon, Patrick, Fitzpatrick, Fidelma, Humphreys, Hilary, De Barra, Eoghan, Kerrigan, Steve W., Cavalleri, Gianpiero L.

“…Introduction : Saliva represents a less invasive alternative to nasopharyngeal swab (NPS) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
Get full text

Concordance between PCR-based extraction-free saliva and nasopharyngeal swabs for SARS-CoV-2 testing by De Santi, Chiara, Jacob, Benson, Kroich, Patricia, Doyle, Sean, Ward, Rebecca, Li, Brian, Donnelly, Owain, Dykes, Amy, Neelakant, Trisha, Neary, David, McGuinness, Ross, Cafferkey, Jacqueline, Ryan, Kieran, Quadu, Veronica, McGrogan, Killian, Garcia Leon, Alejandro, Mallon, Patrick, Fitzpatrick, Fidelma, Humphreys, Hilary, De Barra, Eoghan, Kerrigan, Steve W., Cavalleri, Gianpiero L.

“…Introduction : Saliva represents a less invasive alternative to nasopharyngeal swab (NPS) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
Get full text

Dysregulated early transcriptional signatures linked to mast cell and interferon responses are implicated in COVID-19 severity by MacCann, Rachel, Leon, Alejandro Abner Garcia, Gonzalez, Gabriel, Carr, Michael J, Feeney, Eoin R, Yousif, Obada, Cotter, Aoife G, de Barra, Eoghan, Sadlier, Corinna, Doran, Peter, Mallon, Patrick W

“…Dysregulated immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are thought to underlie the progression of coronavirus…”
Get full text

Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021 by Funk, Tjede, Pharris, Anastasia, Spiteri, Gianfranco, Bundle, Nick, Melidou, Angeliki, Carr, Michael, Gonzalez, Gabriel, Garcia-Leon, Alejandro, Crispie, Fiona, O'Connor, Lois, Murphy, Niamh, Mossong, Joël, Vergison, Anne, Wienecke-Baldacchino, Anke K, Abdelrahman, Tamir, Riccardo, Flavia, Stefanelli, Paola, Di Martino, Angela, Bella, Antonino, Lo Presti, Alessandra, Casaca, Pedro, Moreno, Joana, Borges, Vítor, Isidro, Joana, Ferreira, Rita, Gomes, João Paulo, Dotsenko, Liidia, Suija, Heleene, Epstein, Jevgenia, Sadikova, Olga, Sepp, Hanna, Ikonen, Niina, Savolainen-Kopra, Carita, Blomqvist, Soile, Möttönen, Teemu, Helve, Otto, Gomes-Dias, Joana, Adlhoch, Cornelia

“…We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European…”
Get full text

Biomarker associations with insomnia and secondary sleep outcomes in persons with and without HIV in the POPPY-Sleep substudy: a cohort study by Bakewell, Nicholas, Sabin, Caroline A, Negi, Riya, Garcia-Leon, Alejandro, Winston, Alan, Sachikonye, Memory, Doyle, Nicki, Redline, Susan, Mallon, Patrick W G, Kunisaki, Ken M

“…Abstract Study Objectives We investigated associations between inflammatory profiles/clusters and sleep measures in people living with HIV and…”
Get full text

Associations between host microbiome and inflammation suggest role for host microbiome in driving COVID-19 disease severity by MacCann, Rachel, Ghosh, Tarini Shankar, Garcia Leon, Alejandro Abner, Li, Junhui, Negi, Riya, Gaillard, Colette, Saini, Gurvin, Tinago, Willard, Feeney, Eoin R., Yousif, Obada, Cotter, Aoife G., de Barra, Eoghan, Sadlier, Corinna, Doran, Peter, Landay, Alan, O'Toole, Paul W., Mallon, Patrick W.

“…Systemic inflammation and innate immune activation are associated with COVID-19 disease severity. Knowledge gaps remain in the relationships between…”
Get full text

Performance and validation of an adaptable multiplex assay for detection of serologic response to SARS-CoV-2 infection or vaccination by Kenny, Grace, Negi, Riya, O'Reilly, Sophie, Garcia-Leon, Alejandro, Alalwan, Dana, Gaillard, Colette Marie, Saini, Gurvin, Inzitari, Rosana, Feeney, Eoin R., Yousif, Obada, Cotter, Aoife G, de Barra, Eoghan, Sadlier, Corinna, Crispie, Fiona, Doran, Peter, Gautier, Virginie, Mallon, Patrick W.G.

“…Measurement of quantitative antibody responses are increasingly important in evaluating the immune response to infection and vaccination. In this study we…”
Get full text

Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus by McGettrick, Padraig, Tinago, Willard, O’Brien, Julie, Miles, Sarah, Lawler, Leo, Garcia-Leon, Alejandro, Mahon, Niall, Lambert, John, Sheehan, Gerard, Landay, Alan, Sabin, Caroline A, Cotter, Aoife G, Mallon, Patrick W G

“…Abstract Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity…”
Get full text

IMUNOGENICIDADE DE UM PRIMEIRO REFORÇO COM BNT162B2 OU MRNA-1273 DE DOSE COMPLETA: UM ESTUDO RANDOMIZADO EM ADULTOS ≥75 ANOS (EU-COVAT-1) DO CONSÓRCIO VACCELERATE by Salmanton-Garcia, Jon, Neuhann, Julia M., Stemler, Jannik, Carcas, Antonio, Kumar-Singh, Samir, Leon, Alejandro García, König, Franz, Cornely, Oliver A.

“…A vacinação continua sendo crucial para a proteção contra a infecção grave pelo SARS-CoV-2, especialmente na população idosa. Avaliamos, em um estudo de fase…”
Get full text

Impact of vaccination and variants of concern on long COVID clinical phenotypes by Kenny, Grace, McCann, Kathleen, O'Brien, Conor, O'Broin, Cathal, Tinago, Willard, Yousif, Obada, O'Gorman, Tessa, Cotter, Aoife G, Lambert, John S, Feeney, Eoin R, de Barra, Eoghan, Sadlier, Corinna, Landay, Alan, Doran, Peter, Savinelli, Stefano, Mallon, Patrick W. G, MacCann, Rachel, Garcia Leon, Alejandro, Miles, Sarah, Alalwan, Dana, Negi, Riya, Muldoon, Eavan, Sheehan, Gerard, McGinty, Tara, Green, Sandra, Leamy, Kelly, Kelly, Christine, de Barra, Eoin, McConkey, Samuel, Hurley, Killain, Sulaiman, Imran, Horgan, Mary, Eustace, Joseph, Bracken, Tommy, Whelan, Bryan, Low, Justin, McNicholas, Bairbre, Courtney, Garry, Gavin, Patrick

“…Abstract Background Defining patterns of symptoms in long COVID is necessary to advance therapies for this heterogeneous condition. Here we aimed to describe…”
Get full text

1057. Development of a Flow Cytometry-Based Micro-Neutralisation Assay to Evaluate Humoral Immunity Against SARS-CoV-2 Variants of Concern in Vaccine Trials by O’Reilly, Sophie R, Kenny, Grace, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, de Masson d’Autume, Valentin, Garcia-Leon, Alejandro, Feeney, Eoin, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Horgan, Mary, Mallon, Patrick, BCh, M B, Gautier, Virginie

“…Abstract Background Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses…”
Get full text

312. Performance and validation of an adaptable multiplex assay for detection of serologic response to SARS-CoV-2 infection or vaccination by Kenny, Grace, O’Reilly, Sophie R, Negi, Riya, Garcia-Leon, Alejandro, Alalwan, Dana, Gaillard, Colette Marie, Saini, Gurvin, Inzitari, Rosanna, Feeney, Eoin, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Sadlier, Corinna, Crispie, Fiona, Doran, Peter, Gautier, Virginie, Mallon, Patrick, BCh, M B

“…Abstract Background A wide array of assays to detect the serologic response to SARS-CoV-2 have been developed since the emergence of the pandemic. The majority…”
Get full text