1590 – Subjective experience of specific antipsychotic-related adverse effects in schizophrenia patients
Background Discontinuation of anti-psychotic drugs in schizophrenia patients is a major concern, since it results in relapse and re-hospitalizations. Non-adherence is strongly associated with negative subjective response to antipsychotics which is composed of the subjective experience of negative dr...
Saved in:
| Published in: | European psychiatry Vol. 28; p. 1 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier SAS
2013
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background Discontinuation of anti-psychotic drugs in schizophrenia patients is a major concern, since it results in relapse and re-hospitalizations. Non-adherence is strongly associated with negative subjective response to antipsychotics which is composed of the subjective experience of negative drug effects and attitude towards the treatment. Objective To assess subjective experience towards specific drug-related adverse effects which leads to a generally negative subjective attitude towards antipsychotics. Methods Attitude and experience were measured in schizophrenia inpatients (n=84) on eight subscales: weight gain, sedation, sexual anhedonia, extra-pyramidal syndrome, affective flattening, excessive sleep, diminished sociability and metabolic syndrome. DAI-30 was used to measure attitude towards drugs, and PANSS to assess psychopathology. Results Weak correlation was found between subjective experience and attitude on most of the sub-scales. The only strong, albeit inverse, correlation between experience and attitude that was found was with regard to affective flattening, experienced by 37% of the sample, and it also predicted negative drug attitude as measured by the DAI-30, RR: 1.87 (95% CI: 1.06-3.3, df=1, x2 =4.525, p< 0.05). Conclusion Drug-related affective flattening should be evaluated routinely, since experiencing it may predict negative attitude towards drugs, potentially leading to poor compliance and relapse. |
|---|---|
| ISSN: | 0924-9338 1778-3585 |
| DOI: | 10.1016/S0924-9338(13)76588-X |