Search Results - "Leo, Patrick"

Non-analytic behaviour in large-deviations of the susceptible-infected-recovered model under the influence of lockdowns by Mulholland, Leo Patrick, Feld, Yannick, Hartmann, Alexander K

“…Abstract We numerically investigate the dynamics of an SIR model with infection level-based lockdowns on Small-World networks. Using a large-deviation…”
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Deep-learning approaches for Gleason grading of prostate biopsies by Madabhushi, Anant, Feldman, Michael D, Leo, Patrick

“…Gleason grades are assigned by pathologists based on prostate cancer morphology to describe the loss of tissue structure and order1 and are strongly correlated…”
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Stable and discriminating features are predictive of cancer presence and Gleason grade in radical prostatectomy specimens: a multi-site study by Leo, Patrick, Elliott, Robin, Shih, Natalie N. C., Gupta, Sanjay, Feldman, Michael, Madabhushi, Anant

“…Site variation in fixation, staining, and scanning can confound automated tissue based image classifiers for disease characterization. In this study we…”
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Metabolomic Profile of the Fungus Cryomyces antarcticus Under Simulated Martian and Space Conditions as Support for Life-Detection Missions on Mars by Gevi, Federica, Leo, Patrick, Cassaro, Alessia, Pacelli, Claudia, de Vera, Jean-Pierre Paul, Rabbow, Elke, Timperio, Anna Maria, Onofri, Silvano

“…The identification of traces of life beyond Earth (e.g., Mars, icy moons) is a challenging task because terrestrial chemical-based molecules may be destroyed…”
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Genomic and morphological characterization of Knufia obscura isolated from the Mars 2020 spacecraft assembly facility by Chander, Atul Munish, de Melo Teixeira, Marcus, Singh, Nitin K., Williams, Michael P., Parker, Ceth W., Leo, Patrick, Stajich, Jason E., Torok, Tamas, Tighe, Scott, Mason, Christopher E., Venkateswaran, Kasthuri

“…Members of the family Trichomeriaceae, belonging to the Chaetothyriales order and the Ascomycota phylum, are known for their capability to inhabit hostile…”
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Four principles for improved statistical ecology by Popovic, Gordana, Mason, Tanya Jane, Drobniak, Szymon Marian, Marques, Tiago André, Potts, Joanne, Joo, Rocío, Altwegg, Res, Burns, Carolyn Claire Isabelle, McCarthy, Michael Andrew, Johnston, Alison, Nakagawa, Shinichi, McMillan, Louise, Devarajan, Kadambari, Taggart, Patrick Leo, Wunderlich, Alison, Mair, Magdalena M., Martínez‐Lanfranco, Juan Andrés, Lagisz, Malgorzata, Pottier, Patrice

“…Increasing attention has been drawn to the misuse of statistical methods over recent years, with particular concern about the prevalence of practices such as…”
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A novel imaging based Nomogram for predicting post-surgical biochemical recurrence and adverse pathology of prostate cancer from pre-operative bi-parametric MRI by Li, Lin, Shiradkar, Rakesh, Leo, Patrick, Algohary, Ahmad, Fu, Pingfu, Tirumani, Sree Harsha, Mahran, Amr, Buzzy, Christina, Obmann, Verena C, Mansoori, Bahar, El-Fahmawi, Ayah, Shahait, Mohammed, Tewari, Ashutosh, Magi-Galluzzi, Cristina, Lee, David, Lal, Priti, Ponsky, Lee, Klein, Eric, Purysko, Andrei S., Madabhushi, Anant

“…We developed and validated an integrated radiomic-clinicopathologic nomogram (RadClip) for post-surgical biochemical recurrence free survival (bRFS) and…”
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Image analysis reveals molecularly distinct patterns of TILs in NSCLC associated with treatment outcome by Ding, Ruiwen, Prasanna, Prateek, Corredor, Germán, Barrera, Cristian, Zens, Philipp, Lu, Cheng, Velu, Priya, Leo, Patrick, Beig, Niha, Li, Haojia, Toro, Paula, Berezowska, Sabina, Baxi, Vipul, Balli, David, Belete, Merzu, Rimm, David L., Velcheti, Vamsidhar, Schalper, Kurt, Madabhushi, Anant

“…Despite known histological, biological, and clinical differences between lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC), relatively little is…”
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Automated analysis of computerized morphological features of cell clusters associated with malignancy on bile duct brushing whole slide images by Monabbati, Shayan, Leo, Patrick, Bera, Kaustav, Michael, Claire W., Nezami, Behtash G., Harbhajanka, Aparna, Madabhushi, Anant

“…Background Bile duct brush specimens are difficult to interpret as they often present inflammatory and reactive backgrounds due to the local effects of…”
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Computational image features of immune architecture is associated with clinical benefit and survival in gynecological cancers across treatment modalities by Azarianpour, Sepideh, Corredor, Germán, Bera, Kaustav, Leo, Patrick, Fu, Pingfu, Toro, Paula, Joehlin-Price, Amy, Mokhtari, Mojgan, Mahdi, Haider, Madabhushi, Anant

“…BackgroundWe present a computational approach (ArcTIL) for quantitative characterization of the architecture of tumor-infiltrating lymphocytes (TILs) and their…”
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Genomic characterization and radiation tolerance of Naganishia kalamii sp. nov. and Cystobasidium onofrii sp. nov. from Mars 2020 mission assembly facilities by Leo, Patrick, de Melo Texeira, Marcus, Chander, Atul M, Singh, Nitin K, Simpson, Anna C, Yurkov, Andrey, Karouia, Fathi, Stajich, Jason E, Mason, Christopher E, Venkateswaran, Kasthuri

“…During the construction and assembly of the Mars 2020 mission components at two different NASA cleanrooms, several fungal strains were isolated. Based on their…”
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Yeasts in the Era of Astrobiological Research by Leo, Patrick, Onofri, Silvano

“…Due to their extraordinary genetic and phenotypic plasticity, yeast and yeast-like fungi have been able to adapt and colonize a wide range of ecological…”
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Association of nuclear shape in the tumor epithelium with response to atezolizumab in NSCLC by Leo, Patrick, Patil, Namrata Srivastava, Ruderman, Daniel, Giltnane, Jennifer M., Fuentes, Eloisa, Schedlbauer, Amber, Nabet, Barzin, Kozlowski, Cleopatra

“…8543 Background: Anti-PD-(L)1 treatment is the standard of care for advanced non-small cell lung cancer (NSCLC). However, additional biomarkers are needed to…”
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Automatic myeloblast segmentation in acute myeloid leukemia images based on adversarial feature learning by Zhang, Zelin, Arabyarmohammadi, Sara, Leo, Patrick, Meyerson, Howard, Metheny, Leland, Xu, Jun, Madabhushi, Anant

“…•Presented a novel end-to-end segmentation architecture AMLcGAN based on conditional generative adversarial net (cGAN) to segment acute myeloid leukemia (AML)…”
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Feature-driven local cell graph (FLocK): New computational pathology-based descriptors for prognosis of lung cancer and HPV status of oropharyngeal cancers by Lu, Cheng, Koyuncu, Can, Corredor, German, Prasanna, Prateek, Leo, Patrick, Wang, XiangXue, Janowczyk, Andrew, Bera, Kaustav, Lewis Jr, James, Velcheti, Vamsidhar, Madabhushi, Anant

“…•A new way to construct local cell graphs, named Feature-driven Local Cell Graph (FLocK), which simultaneously consider nuclear properties as well proximities,…”
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Antarctica as a reservoir of planetary analogue environments by Cassaro, Alessia, Pacelli, Claudia, Aureli, Lorenzo, Catanzaro, Ilaria, Leo, Patrick, Onofri, Silvano

“…One of the main objectives of astrobiological research is the investigation of the habitability of other planetary bodies. Since space exploration missions are…”
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Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning-Assisted Gland Analysis by Xie, Weisi, Reder, Nicholas P, Koyuncu, Can, Leo, Patrick, Hawley, Sarah, Huang, Hongyi, Mao, Chenyi, Postupna, Nadia, Kang, Soyoung, Serafin, Robert, Gao, Gan, Han, Qinghua, Bishop, Kevin W, Barner, Lindsey A, Fu, Pingfu, Wright, Jonathan L, Keene, C Dirk, Vaughan, Joshua C, Janowczyk, Andrew, Glaser, Adam K, Madabhushi, Anant, True, Lawrence D, Liu, Jonathan T C

“…Prostate cancer treatment planning is largely dependent upon examination of core-needle biopsies. The microscopic architecture of the prostate glands forms the…”
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Radiomics risk score (RRS) on CT to predict survival and response to CDK 4/6 inhibitors in hormone receptor (HR) positive metastatic breast cancer (MBC) by Kunte, Siddharth, Braman, Nathaniel, Bera, Kaustav, Leo, Patrick, Abraham, Jame, Montero, Alberto J., Madabhushi, Anant

“…Abstract only e13041 Background: The addition of CDK 4/6 inhibitors (CDK) to endocrine therapy (ET) is the standard of care for HR+ MBC. Currently, no robust…”
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Computationally Derived Image Signature of Stromal Morphology Is Prognostic of Prostate Cancer Recurrence Following Prostatectomy in African American Patients by Bhargava, Hersh K, Leo, Patrick, Elliott, Robin, Janowczyk, Andrew, Whitney, Jon, Gupta, Sanjay, Fu, Pingfu, Yamoah, Kosj, Khani, Francesca, Robinson, Brian D, Rebbeck, Timothy R, Feldman, Michael, Lal, Priti, Madabhushi, Anant

“…Between 30%-40% of patients with prostate cancer experience disease recurrence following radical prostatectomy. Existing clinical models for recurrence risk…”
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Novel Radiomic Measurements of Tumor-Associated Vasculature Morphology on Clinical Imaging as a Biomarker of Treatment Response in Multiple Cancers by Braman, Nathaniel, Prasanna, Prateek, Bera, Kaustav, Alilou, Mehdi, Khorrami, Mohammadhadi, Leo, Patrick, Etesami, Maryam, Vulchi, Manasa, Turk, Paulette, Gupta, Amit, Jain, Prantesh, Fu, Pingfu, Pennell, Nathan, Velcheti, Vamsidhar, Abraham, Jame, Plecha, Donna, Madabhushi, Anant

“…The tumor-associated vasculature (TAV) differs from healthy blood vessels by its convolutedness, leakiness, and chaotic architecture, and these attributes…”
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