Search Results - "Lenz, Georg"

Pathogenesis of Non-Hodgkin's Lymphoma by Nogai, Hendrik, Dörken, Bernd, Lenz, Georg

“…The understanding of the molecular pathogenesis of non-Hodgkin's lymphomas (NHL) has significantly improved in recent years. Advances in molecular biology and…”
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Chromatin conformation analysis of primary patient tissue using a low input Hi-C method by Díaz, Noelia, Kruse, Kai, Erdmann, Tabea, Staiger, Annette M., Ott, German, Lenz, Georg, Vaquerizas, Juan M.

“…Chromatin conformation constitutes a fundamental level of eukaryotic genome regulation. However, our ability to examine its biological function and role in…”
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Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma by Dreyling, Martin, Santoro, Armando, Mollica, Luigina, Leppä, Sirpa, Follows, George A, Lenz, Georg, Kim, Won Seog, Nagler, Arnon, Panayiotidis, Panayiotis, Demeter, Judit, Özcan, Muhit, Kosinova, Marina, Bouabdallah, Krimo, Morschhauser, Franck, Stevens, Don A, Trevarthen, David, Giurescu, Marius, Cupit, Lisa, Liu, Li, Köchert, Karl, Seidel, Henrik, Peña, Carol, Yin, Shuxin, Hiemeyer, Florian, Garcia-Vargas, Jose, Childs, Barrett H, Zinzani, Pier Luigi

“…Purpose Phosphatidylinositol 3-kinase (PI3K) signaling is critical for the proliferation and survival of malignant B cells. Copanlisib, a pan-class I PI3K…”
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Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma by Okosun, Jessica, Bödör, Csaba, Wang, Jun, Araf, Shamzah, Yang, Cheng-Yuan, Pan, Chenyi, Boller, Sören, Cittaro, Davide, Bozek, Monika, Iqbal, Sameena, Matthews, Janet, Wrench, David, Marzec, Jacek, Tawana, Kiran, Popov, Nikolay, O'Riain, Ciaran, O'Shea, Derville, Carlotti, Emanuela, Davies, Andrew, Lawrie, Charles H, Matolcsy, András, Calaminici, Maria, Norton, Andrew, Byers, Richard J, Mein, Charles, Stupka, Elia, Lister, T Andrew, Lenz, Georg, Montoto, Silvia, Gribben, John G, Fan, Yuhong, Grosschedl, Rudolf, Chelala, Claude, Fitzgibbon, Jude

“…Jessica Okosun, Csaba Bödör and colleagues performed whole-genome or whole-exome sequencing on 10 follicular lymphoma and transformed follicular lymphoma…”
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Dissection of gene expression datasets into clinically relevant interaction signatures via high-dimensional correlation maximization by Grau, Michael, Lenz, Georg, Lenz, Peter

“…Gene expression is controlled by many simultaneous interactions, frequently measured collectively in biology and medicine by high-throughput technologies. It…”
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Clinical Impact of the Cell-of-Origin Classification and the MYC/ BCL2 Dual Expresser Status in Diffuse Large B-Cell Lymphoma Treated Within Prospective Clinical Trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group by Staiger, Annette M, Ziepert, Marita, Horn, Heike, Scott, David W, Barth, Thomas F E, Bernd, Heinz-Wolfram, Feller, Alfred C, Klapper, Wolfram, Szczepanowski, Monika, Hummel, Michael, Stein, Harald, Lenze, Dido, Hansmann, Martin-Leo, Hartmann, Sylvia, Möller, Peter, Cogliatti, Sergio, Lenz, Georg, Trümper, Lorenz, Löffler, Markus, Schmitz, Norbert, Pfreundschuh, Michael, Rosenwald, Andreas, Ott, German

“…Purpose To explore the prognostic impact and interdependence of the cell-of-origin (COO) classification, dual expression (DE) of MYC and BCL2 proteins, and…”
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PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma by Pfeifer, Matthias, Grau, Michael, Lenze, Dido, Wenzel, Sören-Sebastian, Wolf, Annette, Wollert-Wulf, Brigitte, Dietze, Kerstin, Nogai, Hendrik, Storek, Benjamin, Madle, Hannelore, Dörken, Bernd, Janz, Martin, Dirnhofer, Stephan, Lenz, Peter, Hummel, Michael, Tzankov, Alexandar, Lenz, Georg

“…Diffuse large B-cell lymphoma (DLBCL) represents a heterogeneous diagnostic category with distinct molecular subtypes that can be defined by gene expression…”
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The protease activity of the paracaspase MALT1 is controlled by monoubiquitination by Pelzer, Christiane, Cabalzar, Katrin, Wolf, Annette, Gonzalez, Montserrat, Lenz, Georg, Thome, Margot

“…The CARM1–MALT1–Bcl-10 complex links ligation of the antigen receptor to NF-κB activation. Thome and colleagues show that MALT1 paracaspase activity requires…”
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Immunohistochemical Methods for Predicting Cell of Origin and Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With Rituximab by MEYER, Paul N, KAI FU, VOSE, Julie M, LENZ, Georg, STAUDT, Louis M, CHAN, Wing C, WEISENBURGER, Dennis D, GREINER, Timothy C, SMITH, Lynette M, DELABIE, Jan, GASCOYNE, Randy D, OTT, German, ROSENWALD, Andreas, BRAZIEL, Rita M, CAMPO, Elias

“…Patients with diffuse large B-cell lymphoma (DLBCL) can be divided into prognostic groups based on the cell of origin of the tumor as determined by microarray…”
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Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL by Nagel, Daniel, Spranger, Stefani, Vincendeau, Michelle, Grau, Michael, Raffegerst, Silke, Kloo, Bernhard, Hlahla, Daniela, Neuenschwander, Martin, Peter von Kries, Jens, Hadian, Kamyar, Dörken, Bernd, Lenz, Peter, Lenz, Georg, Schendel, Dolores J., Krappmann, Daniel

“…Proteolytic activity of the mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) paracaspase is required for survival of the activated B…”
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Malt1-dependent RelB cleavage promotes canonical NF-κB activation in lymphocytes and lymphoma cell lines by Hailfinger, Stephan, Nogai, Hendrik, Pelzer, Christiane, Jaworski, Maike, Cabalzar, Katrin, Charton, Jean-Enno, Guzzardi, Montserrat, Décaillet, Chantal, Grau, Michael, Dörken, Bernd, Lenz, Peter, Lenz, Georg, Thome, Margot

“…The protease activity of the paracaspase Malt1 contributes to antigen receptor-mediated lymphocyte activation and lymphomagenesis. Malt1 activity is required…”
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Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma by Steidl, Christian, Lee, Tang, Shah, Sohrab P, Farinha, Pedro, Han, Guangming, Nayar, Tarun, Delaney, Allen, Jones, Steven J, Iqbal, Javeed, Weisenburger, Dennis D, Bast, Martin A, Rosenwald, Andreas, Muller-Hermelink, Hans-Konrad, Rimsza, Lisa M, Campo, Elias, Delabie, Jan, Braziel, Rita M, Cook, James R, Tubbs, Ray R, Jaffe, Elaine S, Lenz, Georg, Connors, Joseph M, Staudt, Louis M, Chan, Wing C, Gascoyne, Randy D

“…Clinically relevant biomarkers for predicting the outcome of treatment in patients with Hodgkin's disease have not been established. In this study, gene…”
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Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing by Pararajalingam, Prasath, Coyle, Krysta M., Arthur, Sarah E., Thomas, Nicole, Alcaide, Miguel, Meissner, Barbara, Boyle, Merrill, Qureshi, Quratulain, Grande, Bruno M., Rushton, Christopher, Slack, Graham W., Mungall, Andrew J., Tam, Constantine S., Agarwal, Rishu, Dawson, Sarah-Jane, Lenz, Georg, Balasubramanian, Sriram, Gascoyne, Randy D., Steidl, Christian, Connors, Joseph, Villa, Diego, Audas, Timothy E., Marra, Marco A., Johnson, Nathalie A., Scott, David W., Morin, Ryan D.

“…Mantle cell lymphoma (MCL) is an uncommon B-cell non-Hodgkin lymphoma (NHL) that is incurable with standard therapies. The genetic drivers of this cancer have…”
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Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation by Knies, Nathalie, Alankus, Begüm, Weilemann, Andre, Tzankov, Alexandar, Brunner, Kristina, Ruff, Tanja, Kremer, Marcus, Keller, Ulrich B., Lenz, Georg, Ruland, Jürgen

“…The aggressive activated B cell-like subtype of diffuse large B-cell lymphoma is characterized by aberrant B-cell receptor (BCR) signaling and constitutive…”
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The molecular pathogenesis of mantle cell lymphoma by Vogt, Niklas, Dai, Beiying, Erdmann, Tabea, Berdel, Wolfgang E., Lenz, Georg

“…Mantle cell lymphoma (MCL) is characterized by the translocation t(11;14) leading to constitutive cyclin D1 overexpression. However, overexpression of cyclin…”
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The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma by Schleussner, Nikolai, Merkel, Olaf, Costanza, Mariantonia, Liang, Huan-Chang, Hummel, Franziska, Romagnani, Chiara, Durek, Pawel, Anagnostopoulos, Ioannis, Hummel, Michael, Jöhrens, Korinna, Niedobitek, Antonia, Griffin, Patrick R., Piva, Roberto, Sczakiel, Henrike L., Woessmann, Wilhelm, Damm-Welk, Christine, Hinze, Christian, Stoiber, Dagmar, Gillissen, Bernd, Turner, Suzanne D., Kaergel, Eva, von Hoff, Linda, Grau, Michael, Lenz, Georg, Dörken, Bernd, Scheidereit, Claus, Kenner, Lukas, Janz, Martin, Mathas, Stephan

“…Transcription factor AP-1 is constitutively activated and IRF4 drives growth and survival in ALK + and ALK – anaplastic large cell lymphoma (ALCL). Here we…”
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Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age by Burkhardt, Birgit, Michgehl, Ulf, Rohde, Jonas, Erdmann, Tabea, Berning, Philipp, Reutter, Katrin, Rohde, Marius, Borkhardt, Arndt, Burmeister, Thomas, Dave, Sandeep, Tzankov, Alexandar, Dugas, Martin, Sandmann, Sarah, Fend, Falko, Finger, Jasmin, Mueller, Stephanie, Gökbuget, Nicola, Haferlach, Torsten, Kern, Wolfgang, Hartmann, Wolfgang, Klapper, Wolfram, Oschlies, Ilske, Richter, Julia, Kontny, Udo, Lutz, Mathias, Maecker-Kolhoff, Britta, Ott, German, Rosenwald, Andreas, Siebert, Reiner, von Stackelberg, Arend, Strahm, Brigitte, Woessmann, Wilhelm, Zimmermann, Martin, Zapukhlyak, Myroslav, Grau, Michael, Lenz, Georg

“…While survival has improved for Burkitt lymphoma patients, potential differences in outcome between pediatric and adult patients remain unclear. In both age…”
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Prostate specific membrane antigen (PSMA) expression in non-small cell lung cancer by Schmidt, Lars Henning, Heitkötter, Birthe, Schulze, Arik B, Schliemann, Christoph, Steinestel, Konrad, Trautmann, Marcel, Marra, Alessandro, Hillejan, Ludger, Mohr, Michael, Evers, Georg, Wardelmann, Eva, Rahbar, Kambiz, Görlich, Dennis, Lenz, Georg, Berdel, Wolfgang E, Hartmann, Wolfgang, Wiewrodt, Rainer, Huss, Sebastian

“…PSMA (prostate-specific membrane antigen) is overexpressed in prostate cancer cells and is reported to be a promising target for antibody-based radioligand…”
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Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils by Fischer, Josephine, Walter, Carolin, Tönges, Alexander, Aleth, Hanna, Jordão, Marta Joana Costa, Leddin, Mathias, Gröning, Verena, Erdmann, Tabea, Lenz, Georg, Roth, Johannes, Vogl, Thomas, Prinz, Marco, Dugas, Martin, Jacobsen, Ilse D., Rosenbauer, Frank

“…Neutrophils are essential first-line defense cells against invading pathogens, yet when inappropriately activated, their strong immune response can cause…”
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Prognostic impact of somatic mutations in diffuse large B-cell lymphoma and relationship to cell-of-origin: data from the phase III GOYA study by Bolen, Christopher R, Klanova, Magdalena, Trneny, Marek, Sehn, Laurie H, He, Jie, Tong, Jing, Paulson, Joseph N, Kim, Eugene, Vitolo, Umberto, Di Rocco, Alice, Fingerle-Rowson, Günter, Nielsen, Tina, Lenz, Georg, Oestergaard, Mikkel Z

“…Diffuse large B-cell lymphoma represents a biologically and clinically heterogeneous diagnostic category with well-defined cell-of-origin subtypes. Using data…”
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