Search Results - "Lenz, Dirk H."

Picomolar Inhibitors as Transition-State Probes of 5′-Methylthioadenosine Nucleosidases by Gutierrez, Jemy A, Luo, Minkui, Singh, Vipender, Li, Lei, Brown, Rosemary L, Norris, Gillian E, Evans, Gary B, Furneaux, Richard H, Tyler, Peter C, Painter, Gavin F, Lenz, Dirk H, Schramm, Vern L

“…Transition states can be predicted from an enzyme’s affinity to related transition-state analogues. 5′-Methylthioadenosine nucleosidases (MTANs) are involved…”
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Energetic Mapping of Transition State Analogue Interactions with Human and Plasmodium falciparum Purine Nucleoside Phosphorylases by Lewandowicz, Andrzej, Ringia, Erika A. Taylor, Ting, Li-Min, Kim, Kami, Tyler, Peter C., Evans, Gary B., Zubkova, Olga V., Mee, Simon, Painter, Gavin F., Lenz, Dirk H., Furneaux, Richard H., Schramm, Vern L.

“…Human purine nucleoside phosphorylase (huPNP) is essential for human T-cell division by removing deoxyguanosine and preventing dGTP imbalance. Plasmodium…”
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Femtomolar Transition State Analogue Inhibitors of 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli by Singh, Vipender, Evans, Gary B., Lenz, Dirk H., Mason, Jennifer M., Clinch, Keith, Mee, Simon, Painter, Gavin F., Tyler, Peter C., Furneaux, Richard H., Lee, Jeffrey E., Howell, P. Lynne, Schramm, Vern L.

“…Escherichia coli 5′-methylthioadenosine/S-adenosyl-homocysteine nucleosidase (MTAN) hydrolyzes its substrates to form adenine and 5-methylthioribose (MTR) or…”
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Synthesis, Formulation, and Adjuvanticity of Monodesmosidic Saponins with Olenanolic Acid, Hederagenin and Gypsogenin Aglycones, and some C‐28 Ester Derivatives by Greatrex, Ben W., Daines, Alison M., Hook, Sarah, Lenz, Dirk H., McBurney, Warren, Rades, Thomas, Rendle, Phillip M.

“…In an attempt to discover a new synthetic vaccine adjuvant, the glycosylation of hederagenin, gypsogenin, and oleanolic acid acceptors with di‐ and…”
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Structure and Inhibition of a Quorum Sensing Target from Streptococcus pneumoniae by Singh, Vipender, Shi, Wuxian, Almo, Steven C, Evans, Gary B, Furneaux, Richard H, Tyler, Peter C, Painter, Gavin F, Lenz, Dirk H, Mee, Simon, Zheng, Renjian, Schramm, Vern L

“…Streptococcus pneumoniae 5‘-methylthioadenosine/S-adenosylhomocysteine hydrolase (MTAN) catalyzes the hydrolytic deadenylation of its substrates to form…”
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Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases by Clinch, Keith, Evans, Gary B, Fleet, George W J, Furneaux, Richard H, Johnson, Stephen W, Lenz, Dirk H, Mee, Simon P H, Rands, Peter R, Schramm, Vern L, Taylor Ringia, Erika A, Tyler, Peter C

“…(1R)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-L-ribitol [(+)-5] and (3S,4S)-1-[(9-deazahypoxanthin-9-yl)methyl]-4-(hydroxymethyl)pyrrolidin-3-ol…”
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Second Generation Transition State Analogue Inhibitors of Human 5‘-Methylthioadenosine Phosphorylase by Evans, Gary B, Furneaux, Richard H, Lenz, Dirk H, Painter, Gavin F, Schramm, Vern L, Singh, Vipender, Tyler, Peter C

“…The polyamine biosynthetic pathway is a therapeutic target for proliferative diseases because cellular proliferation requires elevated levels of polyamines. A…”
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A practical synthesis of (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol by Clinch, Keith, Evans, Gary B, Furneaux, Richard H, Lenz, Dirk H, Mason, Jennifer M, Mee, Simon P H, Tyler, Peter C, Wilcox, Sarah J

“…The title compound (+)-, required for production of transition state analogue inhibitors of enzymes involved in T-cell-dependent disorders, was synthesized in…”
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One-pot transformation of glycopyranosylcyanides to N-( t-butoxycarbonyl)methylamines by Lenz, Dirk H, Norris, Gillian E, Taylor, Carol M, Slim, George C

“…Protected glycopyranosylcyanides were transformed into the corresponding N- tert-butoxycarbonyl-glycopyranosyl methylamines in a one-pot transformation in high…”
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Femtomolar Transition State Analogue Inhibitors of 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli by Vipender Singh, Gary B. Evans, Dirk H. Lenz, Jennifer M. Mason, Keith Clinch, Simon Mee, Gavin F. Painter, Peter C. Tyler, Richard H. Furneaux, Jeffrey E. Lee, P. Lynne Howell, Vern L. Schramm

“…Escherichia coli 5′-methylthioadenosine/S-adenosyl-homocysteine nucleosidase (MTAN) hydrolyzes its substrates to form adenine and 5-methylthioribose (MTR) or…”
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