Search Results - "Lentz, Steven R."

Postoperative bleeding complications in patients with hemophilia undergoing major orthopedic surgery: A prospective multicenter observational study by Kleiboer, Brendan, Layer, Marcus A., Cafuir, Lorraine A., Cuker, Adam, Escobar, Miguel, Eyster, M. Elaine, Kraut, Eric, Leavitt, Andrew D., Lentz, Steven R., Quon, Doris, Ragni, Margaret V., Thornhill, Dianne, Wang, Michael, Key, Nigel S., Buckner, Tyler W.

“…Background Persons with hemophilia (PWH) are at risk for chronic hemophilic arthropathy (HA). Joint replacement surgery may be used to relieve intractable pain…”
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Hydrogen Peroxide Promotes Aging-Related Platelet Hyperactivation and Thrombosis by DAYAL, Sanjana, WILSON, Katina M, MOTTO, David G, MILLER, Francis J, CHAUHAN, Anil K, LENTZ, Steven R

“…The incidence of thrombotic events increases during aging, but the mechanisms are not well understood. To investigate the prothrombotic role of oxidative…”
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Cellular fibronectin containing extra domain A promotes arterial thrombosis in mice through platelet Toll-like receptor 4 by Prakash, Prem, Kulkarni, Paresh P., Lentz, Steven R., Chauhan, Anil K.

“…Cellular fibronectin containing extra domain A (Fn-EDA+), which is produced in response to tissue injury in several disease states, has prothrombotic activity…”
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ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice by Gandhi, Chintan, Khan, Mohammad Moshahid, Lentz, Steven R., Chauhan, Anil K.

“…ADAMTS13, a metalloprotease, plays a pivotal role in preventing spontaneous microvascular thrombosis by cleaving hyperactive ultra large von Willebrand factor…”
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ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice by Gandhi, Chintan, Motto, David G., Jensen, Melissa, Lentz, Steven R., Chauhan, Anil K.

“…Epidemiologic studies suggest that elevated VWF levels and reduced ADAMTS13 activity in the plasma are risk factors for myocardial infarction. However, it…”
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Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation by Dhanesha, Nirav, Ahmad, Ajmal, Prakash, Prem, Doddapattar, Prakash, Lentz, Steven R, Chauhan, Anil K

“…The fibronectin-splicing variant containing extra domain A (Fn-EDA) is present in negligible amounts in the plasma of healthy humans but markedly elevated in…”
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Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E–Deficient Mice by Doddapattar, Prakash, Jain, Manish, Dhanesha, Nirav, Lentz, Steven R, Chauhan, Anil K

“…OBJECTIVE—Fibronectin containing extra domain A (Fn-EDA) is an endogenous ligand of TLR4 (toll-like receptor 4) and is abundant in the extracellular matrix of…”
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Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll-Like Receptor 4 by Doddapattar, Prakash, Gandhi, Chintan, Prakash, Prem, Dhanesha, Nirav, Grumbach, Isabella M, Dailey, Michael E, Lentz, Steven R, Chauhan, Anil K

“…OBJECTIVE—Cellular fibronectin containing extra domain A (EDA-FN) is abundant in the arteries of patients with atherosclerosis. Several in vitro studies…”
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A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase by Ragavan, Vinitha N., Nair, Pramod C., Jarzebska, Natalia, Angom, Ramcharan Singh, Ruta, Luana, Bianconi, Elisa, Grottelli, Silvia, Tararova, Natalia D., Ryazanskiy, Daniel, Lentz, Steven R., Tommasi, Sara, Martens-Lobenhoffer, Jens, Suzuki-Yamamoto, Toshiko, Kimoto, Masumi, Rubets, Elena, Chau, Sarah, Chen, Yingjie, Hu, Xinli, Bernhardt, Nadine, Spieth, Peter M., Weiss, Norbert, Bornstein, Stefan R., Mukhopadhyay, Debabrata, Bode-Böger, Stefanie M., Maas, Renke, Wang, Ying, Macchiarulo, Antonio, Mangoni, Arduino A., Cellini, Barbara, Rodionov, Roman N.

“…Dimethylarginine dimethylaminohydrolase 1 (DDAH1) protects against cardiovascular disease by metabolising the risk factor asymmetric dimethylarginine (ADMA)…”
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Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1 by Li, Fengyin, He, Bing, Ma, Xiaoke, Yu, Shuyang, Bhave, Rupali R., Lentz, Steven R., Tan, Kai, Guzman, Monica L., Zhao, Chen, Xue, Hai-Hui

“…Effective treatment of chronic myelogenous leukemia (CML) largely depends on the eradication of CML leukemic stem cells (LSCs). We recently showed that CML…”
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Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis by Jobe, Shawn M., Wilson, Katina M., Leo, Lorie, Raimondi, Alejandro, Molkentin, Jeffery D., Lentz, Steven R., Di Paola, Jorge

“…Many of the cellular responses that occur in activated platelets resemble events that take place following activation of cell-death pathways in nucleated…”
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Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia by Dayal, Sanjana, Baumbach, Gary L, Arning, Erland, Bottiglieri, Teodoro, Faraci, Frank M, Lentz, Steven R

“…There is an emerging consensus that hyperhomocysteinemia is an independent risk factor for cerebral vascular disease and that homocysteine-lowering therapy…”
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ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice by Dhanesha, Nirav, Doddapattar, Prakash, Chorawala, Mehul R, Nayak, Manasa K, Kokame, Koichi, Staber, Janice M, Lentz, Steven R, Chauhan, Anil K

“…OBJECTIVE—ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type I repeats-13) prevents microvascular thrombosis by cleaving prothrombogenic…”
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Human Alanine-Glyoxylate Aminotransferase 2 Lowers Asymmetric Dimethylarginine and Protects from Inhibition of Nitric Oxide Production by Rodionov, Roman N., Murry, Daryl J., Vaulman, Sarah F., Stevens, Jeff W., Lentz, Steven R.

“…Elevated blood concentrations of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric-oxide (NO) synthase, are found in association with…”
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Alternatively-Spliced Extra Domain A of Fibronectin Promotes Acute Inflammation and Brain Injury After Cerebral Ischemia in Mice by Khan, Mohammad Moshahid, Gandhi, Chintan, Chauhan, Neelam, Stevens, Jeff W., Motto, David G., Lentz, Steven R., Chauhan, Anil K.

“…The fibronectin isoform containing the alternatively spliced extra domain A (EDA(+)-FN) is normally absent from the circulation, but plasma levels of EDA(+)-FN…”
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Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site by Raife, Thomas J., Cao, Wenjing, Atkinson, Bonnie S., Bedell, Bruce, Montgomery, Robert R., Lentz, Steven R., Johnson, George F., Zheng, X. Long

“…The function of von Willebrand factor (VWF) is regulated by proteolysis, which limits its multimeric size and ability to tether platelets. The importance of…”
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Deficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis by Dayal, Sanjana, Gu, Sean X, Hutchins, Ryan D, Wilson, Katina M, Wang, Yi, Fu, Xiaoyun, Lentz, Steven R

“…OBJECTIVE—Clinical evidence suggests an association between oxidative stress and vascular disease, and in vitro studies have demonstrated that reactive oxygen…”
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Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia by Gu, Sean X, Sonkar, Vijay K, Katare, Parmeshwar B, Kumar, Rahul, Kruger, Warren D, Arning, Erland, Bottiglieri, Teodoro, Lentz, Steven R, Dayal, Sanjana

“…Background Hyperhomocysteinemia is a risk factor for ischemic stroke; however, a targeted treatment strategy is lacking partly because of limited understanding…”
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Cooling down VITT with IVIG by Lentz, Steven R.

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Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol‐fed cystathionine beta synthase–deficient mouse by Esfandiari, Farah, Medici, Valentina, Wong, Donna H., Jose, Soumia, Dolatshahi, Maryam, Quinlivan, Eoin, Dayal, Sanjana, Lentz, Steven R., Tsukamoto, Hidekazu, Zhang, Yue Hua, French, Samuel W., Halsted, Charles H.

“…We tested the hypothesis that the pathogenesis of alcoholic liver injury is mediated by epigenetic changes in regulatory genes that result from the induction…”
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