Search Results - "Lentz, Christian S."

From Differential Stains to Next Generation Physiology: Chemical Probes to Visualize Bacterial Cell Structure and Physiology by Hira, Jonathan, Uddin, Md Jalal, Haugland, Marius M, Lentz, Christian S

“…Chemical probes have been instrumental in microbiology since its birth as a discipline in the 19th century when chemical dyes were used to visualize structural…”
Get full text

Development of an inducer-free, virulence gene promoter-controlled, and fluorescent reporter-labeled CRISPR interference system in Staphylococcus aureus by Miah, Roni, Johannessen, Mona, Kjos, Morten, Lentz, Christian S

“…The dCas9-based Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) interference (CRISPRi) gene regulation technique requires two components: a…”
Get full text

Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity by Tomlin, Frederick M, Gerling-Driessen, Ulla I. M, Liu, Yi-Chang, Flynn, Ryan A, Vangala, Janakiram R, Lentz, Christian S, Clauder-Muenster, Sandra, Jakob, Petra, Mueller, William F, Ordoñez-Rueda, Diana, Paulsen, Malte, Matsui, Naoko, Foley, Deirdre, Rafalko, Agnes, Suzuki, Tadashi, Bogyo, Matthew, Steinmetz, Lars M, Radhakrishnan, Senthil K, Bertozzi, Carolyn R

“…Proteasome inhibitors are used to treat blood cancers such as multiple myeloma (MM) and mantle cell lymphoma. The efficacy of these drugs is frequently…”
Get full text

Comprehensive virulence profiling and evolutionary analysis of specificity determinants in Staphylococcus aureus two-component systems by Ahator, Stephen Dela, Wenzl, Karoline, Hegstad, Kristin, Lentz, Christian S, Johannessen, Mona

“…In the genome, a set of highly conserved two-component systems (TCSs) composed of histidine kinases (HKs) and their cognate response regulators (RRs) sense and…”
Get full text

Single-cell phenotypic profiling and backtracing exposes and predicts clinically relevant subpopulations in isogenic Staphylococcus aureus communities by Hira, Jonathan, Singh, Bhupender, Halder, Tirthankar, Mahmutovic, Anel, Ajayi, Clement, Sekh, Arif Ahmed, Hegstad, Kristin, Johannessen, Mona, Lentz, Christian S.

“…Isogenic bacterial cell populations are phenotypically heterogenous and may include subpopulations of antibiotic tolerant or heteroresistant cells. The…”
Get full text

What you see is what you get: activity-based probes in single-cell analysis of enzymatic activities by Lentz, Christian S

“…Molecular imaging methods can provide spatio-temporal information about the distribution of biomolecules or biological processes, such as certain enzymatic…”
Get more information

Fluorescent Triazole Urea Activity‐Based Probes for the Single‐Cell Phenotypic Characterization of Staphylococcus aureus by Chen, Linhai, Keller, Laura J., Cordasco, Edward, Bogyo, Matthew, Lentz, Christian S.

“…Phenotypically distinct cellular (sub)populations are clinically relevant for the virulence and antibiotic resistance of a bacterial pathogen, but functionally…”
Get full text

Activity-Based Protein Profiling in Methicillin-Resistant Staphylococcus aureus Reveals Broad Reactivity of a Carmofur-Derived Probe by Uddin, Md Jalal, Overkleeft, Herman S, Lentz, Christian

“…Activity-based protein profiling is a powerful chemoproteomic technique to detect active enzymes and identify targets and off-targets of drugs. Here, we report…”
Get full text

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP) by Lentz, Christian S., Sheldon, Jessica R., Crawford, Lisa A., Cooper, Rachel, Garland, Megan, Amieva, Manuel R., Weerapana, Eranthie, Skaar, Eric P., Bogyo, Matthew

“…Serine hydrolases play diverse roles in regulating host–pathogen interactions in a number of organisms, yet few have been characterized in the human pathogen…”
Get full text

Activity-based protein profiling of serine hydrolases and penicillin-binding proteins in Enterococcus faecium by Grunnvåg, Jeanette S, Hegstad, Kristin, Lentz, Christian S

“…is a gut commensal bacterium which is gaining increasing relevance as an opportunistic, nosocomial pathogen. Its high level of intrinsic and acquired…”
Get full text

Deciphering Staphylococcus aureus- host dynamics using dual activity-based protein profiling of ATP-interacting proteins by Ahator, Stephen Dela, Hegstad, Kristin, Lentz, Christian S, Johannessen, Mona

“…The utilization of ATP within cells plays a fundamental role in cellular processes that are essential for the regulation of host-pathogen dynamics and the…”
Get full text

Biochemical and Cellular Characterization of the Function of Fluorophosphonate-Binding Hydrolase H (FphH) in Staphylococcus aureus Support a Role in Bacterial Stress Response by Fellner, Matthias, Walsh, Annabel, Dela Ahator, Stephen, Aftab, Nadia, Sutherland, Ben, Tan, Eng W., Bakker, Alexander T., Martin, Nathaniel I., van der Stelt, Mario, Lentz, Christian S.

“…The development of new treatment options for bacterial infections requires access to new targets for antibiotics and antivirulence strategies. Chemoproteomic…”
Get full text

Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of Staphylococcus aureus by Fellner, Matthias, Lentz, Christian S, Jamieson, Sam A, Brewster, Jodi L, Chen, Linhai, Bogyo, Matthew, Mace, Peter D

“…Staphylococcus aureus is a prevalent bacterial pathogen in both community and hospital settings, and its treatment is made particularly difficult by resilience…”
Get full text

Characterization of Serine Hydrolases Across Clinical Isolates of Commensal Skin Bacteria Staphylococcus epidermidis Using Activity-Based Protein Profiling by Keller, Laura J, Lentz, Christian S, Chen, Y. Erin, Metivier, Rebecca J, Weerapana, Eranthie, Fischbach, Michael A, Bogyo, Matthew

“…The bacterial genus Staphylococcus comprises diverse species that colonize the skin as commensals but can also cause infection. Previous work identified a…”
Get full text

Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis by Lentz, Christian S, Ordonez, Alvaro A, Kasperkiewicz, Paulina, La Greca, Florencia, O’Donoghue, Anthony J, Schulze, Christopher J, Powers, James C, Craik, Charles S, Drag, Marcin, Jain, Sanjay K, Bogyo, Matthew

“…Although serine proteases are important mediators of Mycobacterium tuberculosis (Mtb) virulence, there are currently no tools to selectively block or visualize…”
Get full text

Fluorescent Triazole Urea Activity‐Based Probes for the Single‐Cell Phenotypic Characterization of Staphylococcus aureus by Chen, Linhai, Keller, Laura J., Cordasco, Edward, Bogyo, Matthew, Lentz, Christian S.

“…Phenotypically distinct cellular (sub)populations are clinically relevant for the virulence and antibiotic resistance of a bacterial pathogen, but functionally…”
Get full text

New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria by Lentz, Christian S., Stumpfe, Dagmar, Bajorath, Juergen, Famulok, Michael, Hoerauf, Achim, Pfarr, Kenneth M.

“…Substituted benzimidazoles of the wALADin1-family have recently been identified as a new class of species-selective inhibitors of delta-aminolevulinic acid…”
Get full text

wALADin Benzimidazoles Differentially Modulate the Function of Porphobilinogen Synthase Orthologs by Lentz, Christian S, Halls, Victoria S, Hannam, Jeffrey S, Strassel, Silke, Lawrence, Sarah H, Jaffe, Eileen K, Famulok, Michael, Hoerauf, Achim, Pfarr, Kenneth M

“…The heme biosynthesis enzyme porphobilinogen synthase (PBGS) is a potential drug target in several human pathogens. wALADin1 benzimidazoles have emerged as…”
Get full text

In vitro activity of wALADin benzimidazoles against different life cycle stages of Plasmodium parasites by Lentz, Christian S, Sattler, Julia M, Fendler, Martina, Gottwalt, Simon, Halls, Victoria S, Strassel, Silke, Arriens, Sandra, Hannam, Jeffrey S, Specht, Sabine, Famulok, Michael, Mueller, Ann-Kristin, Hoerauf, Achim, Pfarr, Kenneth M

“…wALADin1 benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from Wolbachia endobacteria of filarial nematodes. We report that wALADin1…”
Get full text

A Selective Inhibitor of Heme Biosynthesis in Endosymbiotic Bacteria Elicits Antifilarial Activity In Vitro by Lentz, Christian S., Halls, Victoria, Hannam, Jeffrey S., Niebel, Björn, Strübing, Uta, Mayer, Günter, Hoerauf, Achim, Famulok, Michael, Pfarr, Kenneth M.

“…Lymphatic filariasis and onchocerciasis are severe diseases caused by filarial worms and affect more than 150 million people worldwide. Endosymbiotic…”
Get full text