Search Results - "Lentjes, M. H. F. M."

Meat consumption and K-ras mutations in sporadic colon and rectal cancer in the netherlands cohort study by BRINK, M, WEIJENBERG, M. P, DE GOEIJ, A. F. P. M, ROEMEN, G. M. J. M, LENTJES, M. H. F. M, DE BRUÏNE, A. P, GOLDBOHM, R. A, VAN DEN BRANDT, P. A

“…Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3…”
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Cyclic activity of signal transduction pathways in fimbrial epithelium of the human fallopian tube by Ploeg, Phyllis, Uittenboogaard, Aniek, Bucks, Karlijn M. M., Lentjes‐Beer, Marjolein H. F. M., Bosch, Steven L., Rumste, Minouche M. E., Vos, M. Caroline, Diest, Paul J., Lambrechts, Sandrina, Stolpe, Anja, Bekkers, Ruud L. M., Piek, Jurgen M. J.

“…Introduction The local environment of the fallopian tube represents the optimal conditions for reproductive processes. To maintain tissue homeostasis, signal…”
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N-Myc Downstream-Regulated Gene 4 (NDRG4): A Candidate Tumor Suppressor Gene and Potential Biomarker for Colorectal Cancer by Melotte, Veerle, Lentjes, Marjolein H. F. M., van den Bosch, Sandra M., Hellebrekers, Debby M. E. I., de Hoon, Joep P. J., Wouters, Kim A. D., Daenen, Kathleen L. J., Partouns-Hendriks, Iris E. J. M., Stessels, Filip, Louwagie, Joost, Smits, Kim M., Weijenberg, Matty P., Sanduleanu, Silvia, Khalid-de Bakker, Carolina A. J., Oort, Frank A., Meijer, Gerrit A., Jonkers, Daisy M. A. E., Herman, James G., de Bruïne, Adriaan P., van Engeland, Manon

“…Background Identification of hypermethylated tumor suppressor genes in body fluids is an appealing strategy for the noninvasive detection of colorectal cancer…”
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APC mutations in sporadic colorectal carcinomas from The Netherlands Cohort Study by Lüchtenborg, Margreet, Weijenberg, Matty P., Roemen, Guido M. J. M., de Bruïne, Adriaan P., van den Brandt, Piet A., Lentjes, Marjolein H. F. M., Brink, Mirian, van Engeland, Manon, Goldbohm, R. Alexandra, de Goeij, Anton F. P. M.

“…The adenomatous polyposis coli (APC) gene is considered to be a gatekeeper in colorectal tumourigenesis. Inactivating mutations in APC have been reported in…”
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Functional estrogen receptor signal transduction pathway activity and antihormonal therapy response in low‐grade ovarian carcinoma by Hendrikse, Cynthia S. E., Ploeg, Phyllis, Kruis, Nienke M. A., Wilting, Jody H. C., Oosterkamp, Floor, Theelen, Pauline M. M., Lok, Christianne A. R., Hullu, Joanne A., Smedts, Huberdina P. M., Vos, M. Caroline, Pijlman, Brenda M., Kooreman, Loes F. S., Bulten, Johan, Lentjes‐Beer, Marjolein H. F. M., Bosch, Steven L., Stolpe, Anja, Lambrechts, Sandrina, Bekkers, Ruud L. M., Piek, Jurgen M. J.

“…Background Advanced low‐grade ovarian carcinoma (LGOC) is difficult to treat. In several studies, high estrogen receptor (ER) protein expression was observed…”
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Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study by Brink, Mirian, Weijenberg, Matty P., de Goeij, Anton F. P. M., Schouten, Leo J., Koedijk, Femke D. H., Roemen, Guido M. J. M., Lentjes, Marjolein H. F. M., de Bruïne, Adriaan P., Goldbohm, R.Alexandra, van den Brandt, Piet A.

“…Associations between dietary intake of various fats and specific K-ras mutations in colorectal cancer (CRC) were investigated within the framework of The…”
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Methylation-specific PCR unraveled by Derks, Sarah, Lentjes, Marjolein H F M, Hellebrekers, Debby M E I, de Bruïne, Adriaan P, Herman, James G, van Engeland, Manon

“…Methylation-specific PCR (MSP) is a simple, quick and cost-effective method to analyze the DNA methylation status of virtually any group of CpG sites within a…”
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The emerging role of GATA transcription factors in development and disease by Lentjes, Marjolein H F M, Niessen, Hanneke E C, Akiyama, Yoshimitsu, de Bruïne, Adriaan P, Melotte, Veerle, van Engeland, Manon

“…The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes…”
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Functional estrogen receptor signaling pathway activity in high-grade serous ovarian carcinoma as compared to estrogen receptor protein expression by immunohistochemistry by van der Ploeg, Phyllis, van Lieshout, Laura A. M., van de Stolpe, Anja, Bosch, Steven L., Lentjes-Beer, Marjolein H. F. M., Bekkers, Ruud L. M., Piek, Jurgen M. J.

“…Purpose Anti-estrogen therapy may be used as a palliative treatment option in high-grade serous ovarian carcinomas (HGSC). However, clinical implementation is…”
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NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons by Vaes, N., Lentjes, M. H. F. M., Gijbels, M. J., Rademakers, G., Daenen, K. L., Boesmans, W., Wouters, K. A. D., Geuzens, A., Qu, X., Steinbusch, H. P. J., Rutten, B. P. F., Baldwin, S. H., Sharkey, K. A., Hofstra, R. M. W., Engeland, M., Vanden Berghe, P., Melotte, V.

“…Background Promoter methylation of N‐myc Downstream‐Regulated Gene 4 (NDRG4) in fecal DNA is an established early detection marker for colorectal cancer (CRC)…”
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Dietary folate and APC mutations in sporadic colorectal cancer by de Vogel, Stefan, van Engeland, Manon, Lüchtenborg, Margreet, de Bruïne, Adriaan P, Roemen, Guido M J M, Lentjes, Marjolein H F M, Goldbohm, R Alexandra, van den Brandt, Piet A, de Goeij, Anton F P M, Weijenberg, Matty P

“…Folate deficiency has been associated with colorectal cancer risk and may be involved in colorectal carcinogenesis through increased chromosome instability,…”
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Mitochondrial DNA copy number in colorectal cancer: between tissue comparisons, clinicopathological characteristics and survival by van Osch, Frits H M, Voets, An M, Schouten, Leo J, Gottschalk, Ralph W H, Simons, Colinda C J M, van Engeland, Manon, Lentjes, Marjolein H F M, van den Brandt, Piet A, Smeets, Hubert J M, Weijenberg, Matty P

“…Low mitochondrial DNA (mtDNA) copy number in tumors has been associated with worse prognosis in colorectal cancer (CRC). This study further deciphers the role…”
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GATA4 and GATA5 are Potential Tumor Suppressors and Biomarkers in Colorectal Cancer by Hellebrekers, Debby M E I, Lentjes, Marjolein H F M, van den Bosch, Sandra M, Melotte, Veerle, Wouters, Kim A D, Daenen, Kathleen L J, Smits, Kim M, Akiyama, Yoshimitsu, Yuasa, Yasuhito, Sanduleanu, Silvia, Khalid-de Bakker, Carolina A J, Jonkers, Daisy, Weijenberg, Matty P, Louwagie, Joost, van Criekinge, Wim, Carvalho, Beatriz, Meijer, Gerrit A, Baylin, Stephen B, Herman, James G, de Bruïne, Adriaan P, van Engeland, Manon

“…Purpose: The transcription factors GATA4 and GATA5 are involved in gastrointestinal development and are inactivated by promoter hypermethylation in colorectal…”
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Spectrin repeat containing nuclear envelope 1 and forkhead box protein E1 are promising markers for the detection of colorectal cancer in blood by Melotte, Veerle, Yi, Joo Mi, Lentjes, Marjolein H F M, Smits, Kim M, Van Neste, Leander, Niessen, Hanneke E C, Wouters, Kim A D, Louwagie, Joost, Schuebel, Kornel E, Herman, James G, Baylin, Stephen B, van Criekinge, Wim, Meijer, Gerrit A, Ahuja, Nita, van Engeland, Manon

“…Identifying biomarkers in body fluids may improve the noninvasive detection of colorectal cancer. Previously, we identified N-Myc downstream-regulated gene 4…”
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K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study by Brink, Mirian, de Goeij, Anton F.P.M., Weijenberg, Matty P., Roemen, Guido M.J.M., Lentjes, Marjolein H.F.M., Pachen, Marco M.M., Smits, Kim M., de Bruïne, Adriaan P., Goldbohm, R. Alexandra, van den Brandt, Piet A.

“…Activation of K-ras oncogene has been implicated in colorectal carcinogenesis, being mutated in 30–60% of the adenocarcinomas. In this study, 737 incident…”
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Methylation-associated dysregulation of the suppressor of cytokine signaling-3 gene in multiple myeloma by Wilop, Stefan, van Gemmeren, Thomas B., Lentjes, Marjolein H.F.M., van Engeland, Manon, Herman, James G., Brümmendorf, Tim H., Jost, Edgar, Galm, Oliver

“…The family of suppressor of cytokine signaling (SOCS) proteins negatively regulates cytokine signaling in different cellular pathways including interleukin-6…”
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Meat and Fish Consumption, APC Gene Mutations and hMLH1 Expression in Colon and Rectal Cancer: A Prospective Cohort Study (The Netherlands) by Lüchtenborg, Margreet, Weijenberg, Matty P., de Goeij, Anton F. P. M., Wark, Petra A., Brink, Mirian, Roemen, Guido M. J. M., Lentjes, Marjolein H. F. M., de Bruïne, Adriaan P., Goldbohm, R. Alexandra, van 't Veer, Pieter, van den Brandt, Piet A.

“…Objective: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon…”
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Dietary folate intake and k‐ras mutations in sporadic colon and rectal cancer in the Netherlands Cohort Study by Brink, Mirian, Weijenberg, Matty P., de Goeij, Anton F.P.M., Roemen, Guido M.J.M., Lentjes, Marjolein H.F.M., de Bruïne, Adriaan P., van Engeland, Manon, Goldbohm, R. Alexandra, van den Brandt, Piet A.

“…We studied the association between dietary folate and specific K‐ras mutations in colon and rectal cancer in The Netherlands Cohort Study on diet and cancer…”
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Meat and Fish Consumption, APCGene Mutations and hMLH1 Expression in Colon and Rectal Cancer: a Prospective Cohort Study (The Netherlands) by Lüchtenborg, Margreet, Weijenberg, Matty P., de Goeij, Anton F. P. M., Wark, Petra A., Brink, Mirian, Roemen, Guido M. J. M., Lentjes, Marjolein H. F. M., de Bruïne, Adriaan P., Goldbohm, R. Alexandra, van ‘t Veer, Pieter, van den Brandt, Piet A.

“…Objective:The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and…”
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NDRG 4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons by Vaes, N., Lentjes, M. H. F. M., Gijbels, M. J., Rademakers, G., Daenen, K. L., Boesmans, W., Wouters, K. A. D., Geuzens, A., Qu, X., Steinbusch, H. P. J., Rutten, B. P. F., Baldwin, S. H., Sharkey, K. A., Hofstra, R. M. W., van Engeland, M., Vanden Berghe, P., Melotte, V.

“…Abstract Background Promoter methylation of N‐myc Downstream‐Regulated Gene 4 ( NDRG 4) in fecal DNA is an established early detection marker for colorectal…”
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