Search Results - "Lenting, Peter J"

Emicizumab and thrombosis: The story so far by Makris, Michael, Iorio, Alfonso, Lenting, Peter J.

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von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends by Lenting, Peter J., Christophe, Olivier D., Denis, Cécile V.

“…To understand the placement of a certain protein in a physiological system and the pathogenesis of related disorders, it is not only of interest to determine…”
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Laboratory monitoring of hemophilia A treatments: new challenges by Lenting, Peter J.

“…Monitoring factor VIII (FVIII) activity has traditionally been complicated by discrepancies between assays for the various sorts of FVIII molecules. The advent…”
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Ex vivo editing of human hematopoietic stem cells for erythroid expression of therapeutic proteins by Pavani, Giulia, Laurent, Marine, Fabiano, Anna, Cantelli, Erika, Sakkal, Aboud, Corre, Guillaume, Lenting, Peter J., Concordet, Jean-Paul, Toueille, Magali, Miccio, Annarita, Amendola, Mario

“…Targeted genome editing has a great therapeutic potential to treat disorders that require protein replacement therapy. To develop a platform independent of…”
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Arterial Pulsatility and Circulating von Willebrand Factor in Patients on Mechanical Circulatory Support by Vincent, Flavien, Rauch, Antoine, Loobuyck, Valentin, Robin, Emmanuel, Nix, Christoph, Vincentelli, André, Smadja, David M., Leprince, Pascal, Amour, Julien, Lemesle, Gilles, Spillemaeker, Hugues, Debry, Nicolas, Latremouille, Christian, Jansen, Piet, Capel, Antoine, Moussa, Mouhamed, Rousse, Natacha, Schurtz, Guillaume, Delhaye, Cédric, Paris, Camille, Jeanpierre, Emmanuelle, Dupont, Annabelle, Corseaux, Delphine, Rosa, Mickaël, Sottejeau, Yoann, Barth, Svenja, Mourran, Claudia, Gomane, Valérie, Coisne, Augustin, Richardson, Marjorie, Caron, Claudine, Preda, Cristian, Ung, Alexandre, Carpentier, Alain, Hubert, Thomas, Denis, Cécile, Staels, Bart, Lenting, Peter J., Van Belle, Eric, Susen, Sophie

“…The main risk factor for bleeding in patients with continuous-flow mechanical circulatory support (CF-MCS) is the acquired von Willebrand factor (VWF) defect…”
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Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant by McIntosh, Jenny, Lenting, Peter J., Rosales, Cecilia, Lee, Doyoung, Rabbanian, Samira, Raj, Deepak, Patel, Nishil, Tuddenham, Edward G.D., Christophe, Olivier D., McVey, John H., Waddington, Simon, Nienhuis, Arthur W., Gray, John T., Fagone, Paolo, Mingozzi, Federico, Zhou, Shang-Zhen, High, Katherine A., Cancio, Maria, Ng, Catherine Y.C., Zhou, Junfang, Morton, Christopher L., Davidoff, Andrew M., Nathwani, Amit C.

“…Recombinant adeno-associated virus (rAAV) vectors encoding human factor VIII (hFVIII) were systematically evaluated for hemophilia A (HA) gene therapy. A…”
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How to keep the factor VIII/von Willebrand factor complex in the circulation by Denis, Cécile V., Lenting, Peter J.

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Differences in venous clot structures between hemophilic mice treated with emicizumab versus factor VIII or factor VIIIFc by Sefiane, Thibaud, Maynadié, Hortense, Ettingshausen, Carmen Escurola, Muczynski, Vincent, Heiligenstein, Xavier, Dumont, Julien, Christophe, Olivier D, Denis, Cécile V, Casari, Caterina, Lenting, Peter J

“…Recombinant factor VIII (rFVIII), rFVIIIFc and emicizumab are established treatment options in the management of hemophilia A. Each has its unique mode of…”
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The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice by Denorme, Frederik, Martinod, Kimberly, Vandenbulcke, Aline, Denis, Cécile V, Lenting, Peter J, Deckmyn, Hans, Vanhoorelbeke, Karen, De Meyer, Simon F

“…von Willebrand factor (VWF) plays an important role in ischemic stroke. However, the exact mechanism by which VWF mediates progression of ischemic stroke brain…”
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Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor by Wohner, Nikolett, Muczynski, Vincent, Mohamadi, Amel, Legendre, Paulette, Proulle, Valérie, Aymé, Gabriel, Christophe, Olivier D, Lenting, Peter J, Denis, Cécile V, Casari, Caterina

“…Previously, we found that LDL-receptor related protein-1 on macrophages mediated shear stress-dependent clearance of von Willebrand factor. In control…”
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Non-inhibitory antibodies inducing increased emicizumab clearance in a severe haemophilia A inhibitor patient by Harroche, Annie, Sefiane, Thibaud, Desvages, Maximilien, Borgel, Delphine, Lasne, Dominique, Casari, Caterina, Peyron, Ivan, Frenzel, Laurent, Chhun, Stéphanie, Lenting, Peter J, Bally, Cécile

“…Authorship Contributions: AH, CB were in charge of the patients and provided the clinical samples. MD, DB and DL performed the coagulation tests. TS, CC, IP…”
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Correction of bleeding in experimental severe hemophilia A by systemic delivery of factor VIII-encoding mRNA by Russick, Jules, Delignat, Sandrine, Milanov, Peter, Christophe, Olivier, Boros, Gábor, Denis, Cécile V, Lenting, Peter J, Kaveri, Srinivas V, Lacroix-Desmazes, Sébastien

“…The treatment or prevention of bleeding in patients with hemophilia A relies on replacement therapy with different factor VIII (FVIII)-containing products or…”
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Author Correction: Ex vivo editing of human hematopoietic stem cells for erythroid expression of therapeutic proteins by Pavani, Giulia, Laurent, Marine, Fabiano, Anna, Cantelli, Erika, Sakkal, Aboud, Corre, Guillaume, Lenting, Peter J., Concordet, Jean-Paul, Toueille, Magali, Miccio, Annarita, Amendola, Mario

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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von Willebrand Factor as a Biological Sensor of Blood Flow to Monitor Percutaneous Aortic Valve Interventions by Van Belle, Eric, Rauch, Antoine, Vincentelli, André, Jeanpierre, Emmanuelle, Legendre, Paulette, Juthier, Francis, Hurt, Christopher, Banfi, Carlo, Rousse, Natacha, Godier, Anne, Caron, Claudine, Elkalioubie, Ahmed, Corseaux, Delphine, Dupont, Annabelle, Zawadzki, Christophe, Delhaye, Cédric, Mouquet, Frédéric, Schurtz, Guillaume, Deplanque, Dominique, Chinetti, Giulia, Staels, Bart, Goudemand, Jenny, Jude, Brigitte, Lenting, Peter J., Susen, Sophie

“…RATIONALE:Percutaneous aortic valve procedures are a major breakthrough in the management of patients with aortic stenosis. Residual gradient and residual…”
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Macrophage LRP1 contributes to the clearance of von Willebrand factor by Rastegarlari, Ghasem, Pegon, Julie N., Casari, Caterina, Odouard, Soline, Navarrete, Ana-Maria, Saint-Lu, Nathalie, van Vlijmen, Bart J., Legendre, Paulette, Christophe, Olivier D., Denis, Cécile V., Lenting, Peter J.

“…The relationship between low-density lipoprotein receptor–related protein-1 (LRP1) and von Willebrand factor (VWF) has remained elusive for years. Indeed,…”
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PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space by Cloesmeijer, Michael E., Sjögren, Erik, Koopman, Sjoerd F., Lenting, Peter. J., Cnossen, Marjon H., Mathôt, Ron A. A.

“…Patients with severe and sometimes moderate hemophilia B are prophylactically treated with factor IX concentrates to prevent bleeding. For some time now,…”
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Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B–associated thrombocytopenia by Casari, Caterina, Du, Vivian, Wu, Ya-Ping, Kauskot, Alexandre, de Groot, Philip G., Christophe, Olivier D., Denis, Cécile V., de Laat, Bas, Lenting, Peter J.

“…Von Willebrand disease (VWD) type 2B is characterized by mutations causing enhanced binding of von Willebrand factor (VWF) to platelets. Bleeding tendency is…”
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Transient von Willebrand factor‐mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice by Kirschbaum, Marc, Jenne, Craig N., Veldhuis, Zwanida J., Sjollema, Klaas A., Lenting, Peter J., Giepmans, Ben N. G., Porte, Robert J., Kubes, Paul, Denis, Cécile V., Lisman, Ton

“…Background & Aims In addition to their function in thrombosis and haemostasis, platelets play an important role in the stimulation of liver regeneration. It…”
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Monoclonal gammopathy of clinical significance: in vivo demonstration of the anti-thrombotic effect of an acquired anti-thrombin antibody by Schell, Berenice, Desconclois, Celine, Mariette, Xavier, Goujard, Cecile, Lenting, Peter J, Denis, Cecile V, Proulle, Valerie

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Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1 by Lebbink, Robert Jan, de Ruiter, Talitha, Adelmeijer, Jelle, Brenkman, Arjan B, van Helvoort, Joop M, Koch, Manuel, Farndale, Richard W, Lisman, Ton, Sonnenberg, Arnoud, Lenting, Peter J, Meyaard, Linde

“…Collagens are the most abundant proteins in the human body, important in maintenance of tissue structure and hemostasis. Here we report that collagens are high…”
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