Search Results - "Lenthall, Helen"

Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome by Pelham, Simon J., MSc, Lenthall, Helen C., MMSc, Deenick, Elissa K., PhD, Tangye, Stuart G., PhD

“…Consistent with these findings, induction of the STAT3 target genes SOCS3 (Fig 2, C), PRDM1 (encoding BLIMP-1), and IL2RA (Fig E2, A and B) were significantly…”
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Germline-activating mutations in PIK3CD compromise B cell development and function by Avery, Danielle T, Kane, Alisa, Nguyen, Tina, Lau, Anthony, Nguyen, Akira, Lenthall, Helen, Payne, Kathryn, Shi, Wei, Brigden, Henry, French, Elise, Bier, Julia, Hermes, Jana R, Zahra, David, Sewell, William A, Butt, Danyal, Elliott, Michael, Boztug, Kaan, Meyts, Isabelle, Choo, Sharon, Hsu, Peter, Wong, Melanie, Berglund, Lucinda J, Gray, Paul, O'Sullivan, Michael, Cole, Theresa, Holland, Steven M, Ma, Cindy S, Burkhart, Christoph, Corcoran, Lynn M, Phan, Tri Giang, Brink, Robert, Uzel, Gulbu, Deenick, Elissa K, Tangye, Stuart G

“…Gain-of-function (GOF) mutations in , encoding the p110δ subunit of phosphatidylinositide 3-kinase (PI3K), cause a primary immunodeficiency. Affected…”
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Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies by Rouet, Romain, Mazigi, Ohan, Walker, Gregory J., Langley, David B., Sobti, Meghna, Schofield, Peter, Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Henry, Jake Y., Abayasingam, Arunasingam, Burnett, Deborah, Kelleher, Anthony, Brink, Robert, Bull, Rowena A., Turville, Stuart, Stewart, Alastair G., Goodnow, Christopher C., Rawlinson, William D., Christ, Daniel

“…Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant…”
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T cell dysfunction in Activated PI3K δ Syndrome explained by cell intrinsic and extrinsic components by Bier, Julia, Lau, Anthony, Brink, Robert Adrian, Ruiz-Diaz, Stephanie, Lenthall, Helen, Tangye, Stuart, Deenick, Elissa

“…Abstract Activated PI3K Delta Syndrome (APDS) is a rare condition caused by heterozygous gain of function mutations in PIK3CD, which encodes the…”
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Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability by Burnett, Deborah L., Jackson, Katherine J.L., Langley, David B., Aggarwal, Anupriya, Stella, Alberto Ospina, Johansen, Matt D., Balachandran, Harikrishnan, Lenthall, Helen, Rouet, Romain, Walker, Gregory, Saunders, Bernadette M., Singh, Mandeep, Li, Hui, Henry, Jake Y., Jackson, Jennifer, Stewart, Alastair G., Witthauer, Franka, Spence, Matthew A., Hansbro, Nicole G., Jackson, Colin, Schofield, Peter, Milthorpe, Claire, Martinello, Marianne, Schulz, Sebastian R., Roth, Edith, Kelleher, Anthony, Emery, Sean, Britton, Warwick J., Rawlinson, William D., Karl, Rudolfo, Schäfer, Simon, Winkler, Thomas H., Brink, Robert, Bull, Rowena A., Hansbro, Philip M., Jäck, Hans-Martin, Turville, Stuart, Christ, Daniel, Goodnow, Christopher C.

“…Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Second-generation vaccines will need to elicit neutralizing antibodies…”
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Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4+ T cells by Bier, Julia, Rao, Geetha, Payne, Kathryn, Brigden, Henry, French, Elise, Pelham, Simon J., Lau, Anthony, Lenthall, Helen, Edwards, Emily S.J., Smart, Joanne M., Cole, Theresa S., Choo, Sharon, Joshi, Avni Y., Abraham, Roshini S., O'Sullivan, Michael, Boztug, Kaan, Meyts, Isabelle, Gray, Paul E., Berglund, Lucinda J., Hsu, Peter, Wong, Melanie, Holland, Steven M., Notarangelo, Luigi D., Uzel, Gulbu, Ma, Cindy S., Brink, Robert, Tangye, Stuart G., Deenick, Elissa K.

“…Gain-of-function (GOF) mutations in PIK3CD cause a primary immunodeficiency characterized by recurrent respiratory tract infections, susceptibility to…”
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Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production by Lau, Anthony, Avery, Danielle T, Jackson, Katherine, Lenthall, Helen, Volpi, Stefano, Brigden, Henry, Russell, Amanda J, Bier, Julia, Reed, Joanne H, Smart, Joanne M, Cole, Theresa, Choo, Sharon, Gray, Paul E, Berglund, Lucinda J, Hsu, Peter, Wong, Melanie, O'Sullivan, Michael, Boztug, Kaan, Meyts, Isabelle, Uzel, Gulbu, Notarangelo, Luigi D, Brink, Robert, Goodnow, Christopher C, Tangye, Stuart G, Deenick, Elissa K

“…Antibody-mediated autoimmune diseases are a major health burden. However, our understanding of how self-reactive B cells escape self-tolerance checkpoints to…”
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Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients by Rouet, Romain, Henry, Jake Y., Johansen, Matt D., Sobti, Meghna, Balachandran, Harikrishnan, Langley, David B., Walker, Gregory J., Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Mazigi, Ohan, Schofield, Peter, Burnett, Deborah L., Brown, Simon H. J., Martinello, Marianne, Hudson, Bernard, Gilroy, Nicole, Post, Jeffrey J., Kelleher, Anthony, Jäck, Hans-Martin, Goodnow, Christopher C., Turville, Stuart G., Rawlinson, William D., Bull, Rowena A., Stewart, Alastair G., Hansbro, Philip M., Christ, Daniel

“…Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-2 monoclonal antibodies and vaccines currently used in clinical…”
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B cell–intrinsic requirement for STK4 in humoral immunity in mice and human subjects by Moran, Imogen, Avery, Danielle T., Payne, Kathryn, Lenthall, Helen, Davies, E. Graham, Burns, Siobhan, Ip, Winnie, Oleastro, Matÿfffedas M., Reisli, Ismail, Guner, Sukru, Keles, Sevgi, Notarangelo, Luigi, Deenick, Elissa K., Goodnow, Christopher C., Zahra, David, Brink, Robert, Wong, Melanie, Tangye, Stuart G., Ma, Cindy S., Phan, Tri Giang

“…To the Editor: Biallelic loss-of-function mutations in serine-threonine kinase 4 (STK4), also known as mammalian sterile 20-like 1 (MST1), are associated with…”
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Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2 by Nguyen, Tina, Lau, Anthony, Bier, Julia, Cooke, Kristen C, Lenthall, Helen, Ruiz-Diaz, Stephanie, Avery, Danielle T, Brigden, Henry, Zahra, David, Sewell, William A, Droney, Luke, Okada, Satoshi, Asano, Takaki, Abolhassani, Hassan, Chavoshzadeh, Zahra, Abraham, Roshini S, Rajapakse, Nipunie, Klee, Eric W, Church, Joseph A, Williams, Andrew, Wong, Melanie, Burkhart, Christoph, Uzel, Gulbu, Croucher, David R, James, David E, Ma, Cindy S, Brink, Robert, Tangye, Stuart G, Deenick, Elissa K

“…Heterozygous loss-of-function (LOF) mutations in PIK3R1 (encoding phosphatidylinositol 3-kinase [PI3K] regulatory subunits) cause activated PI3Kδ syndrome 2…”
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Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia by Aggarwal, Anupriya, Stella, Alberto Ospina, Walker, Gregory, Akerman, Anouschka, Esneau, Camille, Milogiannakis, Vanessa, Burnett, Deborah L., McAllery, Samantha, Silva, Mariana Ruiz, Lu, Yonghui, Foster, Charles S. P., Brilot, Fabienne, Pillay, Aleha, Van Hal, Sabastiaan, Mathivanan, Vennila, Fichter, Christina, Kindinger, Andrea, Hoppe, Alexandra Carey, Munier, Mee Ling, Amatayakul-Chantler, Supavadee, Roth, Nathan, Coppola, Germano, Symonds, Geoff P., Schofield, Peter, Jackson, Jennifer, Lenthall, Helen, Henry, Jake Y., Mazigi, Ohan, Jäck, Hans-Martin, Davenport, Miles P., Darley, David R., Matthews, Gail V., Khoury, David S., Cromer, Deborah, Goodnow, Christopher C., Christ, Daniel, Robosa, Roselle, Starck, Damien J., Bartlett, Nathan W., Rawlinson, William D., Kelleher, Anthony D., Turville, Stuart G.

“…Genetically distinct variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged since the start of the COVID-19 pandemic. Over this…”
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Activating mutations in PIK3CD and murine CD4+ T cells by Bier, Julia, Rao, Geetha, Payne, Kathryn, Brigden, Henry, French, Elise, Pelham, Simon J., Lau, Anthony, Lenthall, Helen, Edwards, Emily S.J., Smart, Joanne M., Cole, Theresa S., Choo, Sharon, Joshi, Avni Y., Abraham, Roshini S., O’Sullivan, Michael, Boztug, Kaan, Meyts, Isabelle, Gray, Paul E, Berglund, Lucinda J, Hsu, Peter, Wong, Melanie, Holland, Steven M., Notarangelo, Luigi D., Uzel, Gulbu, Ma, Cindy S., Brink, Robert, Tangye, Stuart G., Deenick, Elissa K.

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Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse by Conway, James R W, Warren, Sean C, Lee, Young-Kyung, McCulloch, Andrew T, Magenau, Astrid, Lee, Victoria, Metcalf, Xanthe L, Stoehr, Janett, Haigh, Katharina, Abdulkhalek, Lea, Guaman, Cristian S, Reed, Daniel A, Murphy, Kendelle J, Pereira, Brooke A, Mélénec, Pauline, Chambers, Cecilia, Latham, Sharissa L, Lenthall, Helen, Deenick, Elissa K, Ma, Yuanqing, Phan, Tri, Lim, Elgene, Joshua, Anthony M, Walters, Stacey, Grey, Shane T, Shi, Yan-Chuan, Zhang, Lei, Herzog, Herbert, Croucher, David R, Philp, Andy, Scheele, Colinda L G J, Herrmann, David, Sansom, Owen J, Morton, Jennifer P, Papa, Antonella, Haigh, Jody J, Nobis, Max, Timpson, Paul

“…Aberrant AKT activation occurs in a number of cancers, metabolic syndrome, and immune disorders, making it an important target for the treatment of many…”
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B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans by Moran, Imogen, Avery, Danielle T, Payne, Kathryn, Lenthall, Helen, Davies, E Graham, Burns, Siobhan, Ip, Winnie, Oleastro, Matÿfffedas M, Reisli, Ismail, Guner, Sukru, Keles, Sevgi, Notarangelo, Luigi, Deenick, Elissa K, Goodnow, Christopher C, Zahra, David, Brink, Robert, Wong, Melanie, Tangye, Stuart G, Ma, Cindy S, Phan, Tri Giang

“…Humoral immune defects are described in 9 patients from 5 families with STK4 deficiency. A mouse model carrying the novel p.Y88del show that these defects are…”
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Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies by Rouet, Romain, Mazigi, Ohan, Walker, Gregory J., Langley, David B., Sobti, Meghna, Schofield, Peter, Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Henry, Jake Y., Abayasingam, Arunasingam, Burnett, Deborah, Kelleher, Anthony, Brink, Robert, Bull, Rowena A., Turville, Stuart, Stewart, Alastair G., Goodnow, Christopher C., Rawlinson, William D., Christ, Daniel

“…Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant…”
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