Search Results - "Lentacker, Ine"

The dawn of mRNA vaccines: The COVID-19 case by Verbeke, Rein, Lentacker, Ine, De Smedt, Stefaan C., Dewitte, Heleen

“…In less than one year since the outbreak of the COVID-19 pandemic, two mRNA-based vaccines, BNT162b2 and mRNA-1273, were granted the first historic…”
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The Role of Ultrasound-Driven Microbubble Dynamics in Drug Delivery: From Microbubble Fundamentals to Clinical Translation by Roovers, Silke, Segers, Tim, Lajoinie, Guillaume, Deprez, Joke, Versluis, Michel, De Smedt, Stefaan C, Lentacker, Ine

“…In the last couple of decades, ultrasound-driven microbubbles have proven excellent candidates for local drug delivery applications. Besides being useful drug…”
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mRNA in cancer immunotherapy: beyond a source of antigen by Van Hoecke, Lien, Verbeke, Rein, Dewitte, Heleen, Lentacker, Ine, Vermaelen, Karim, Breckpot, Karine, Van Lint, Sandra

“…mRNA therapeutics have become the focus of molecular medicine research. Various mRNA applications have reached major milestones at high speed in the…”
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Sonoprinting and the importance of microbubble loading for the ultrasound mediated cellular delivery of nanoparticles by De Cock, Ine, Lajoinie, Guillaume, Versluis, Michel, De Smedt, Stefaan C, Lentacker, Ine

“…Abstract In the last years, research on ultrasound mediated drug delivery using microbubbles is vastly expanding. While some groups simply mix drugs and…”
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Comparison of Gold Nanoparticle Mediated Photoporation: Vapor Nanobubbles Outperform Direct Heating for Delivering Macromolecules in Live Cells by Xiong, Ranhua, Raemdonck, Koen, Peynshaert, Karen, Lentacker, Ine, De Cock, Ine, Demeester, Jo, De Smedt, Stefaan C, Skirtach, Andre G, Braeckmans, Kevin

“…There is a great interest in delivering macromolecular agents into living cells for therapeutic purposes, such as siRNA for gene silencing. Although…”
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Crucial factors and emerging concepts in ultrasound-triggered drug delivery by Geers, Bart, Dewitte, Heleen, De Smedt, Stefaan C., Lentacker, Ine

“…Time and space controlled drug delivery still remains a huge challenge in medicine. A novel approach that could offer a solution is ultrasound guided drug…”
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Design and Evaluation of Doxorubicin-containing Microbubbles for Ultrasound-triggered Doxorubicin Delivery: Cytotoxicity and Mechanisms Involved by Lentacker, Ine, Geers, Bart, Demeester, Joseph, De Smedt, Stefaan C, Sanders, Niek N

“…Drug delivery with microbubbles and ultrasound is gaining more and more attention in the drug delivery field due to its noninvasiveness, local applicability,…”
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The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy by Dewitte, Heleen, Van Lint, Sandra, Heirman, Carlo, Thielemans, Kris, De Smedt, Stefaan C., Breckpot, Karine, Lentacker, Ine

“…Dendritic cell (DC)-based cancer vaccines, where the patient's own immune system is harnessed to target and destroy tumor tissue, have emerged as a potent…”
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Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes by Mayer, Rupert L., Verbeke, Rein, Asselman, Caroline, Aernout, Ilke, Gul, Adillah, Eggermont, Denzel, Boucher, Katie, Thery, Fabien, Maia, Teresa M., Demol, Hans, Gabriels, Ralf, Martens, Lennart, Bécavin, Christophe, De Smedt, Stefaan C., Vandekerckhove, Bart, Lentacker, Ine, Impens, Francis

“…Listeria monocytogenes is a foodborne intracellular bacterial pathogen leading to human listeriosis. Despite a high mortality rate and increasing antibiotic…”
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mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells by De Temmerman, Marie-Luce, Dewitte, Heleen, Vandenbroucke, Roosmarijn E, Lucas, Bart, Libert, Claude, Demeester, Jo, De Smedt, Stefaan C, Lentacker, Ine, Rejman, Joanna

“…Abstract In cancer immunotherapy the immune system should be triggered to specifically recognize and eliminate tumor cells in the patient’s body. This could be…”
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Targeted Liposome-Loaded Microbubbles for Cell-Specific Ultrasound-Triggered Drug Delivery by Geers, Bart, De Wever, Olivier, Demeester, Joseph, Bracke, Marc, De Smedt, Stefaan C., Lentacker, Ine

“…One of the main problems in cancer treatment is disease relapse through metastatic colonization, which is caused by circulating tumor cells (CTCs). This work…”
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Microvascular Injury and Perfusion Changes Induced by Ultrasound and Microbubbles in a Machine-Perfused Pig Liver by Keravnou, Christina P, De Cock, Ine, Lentacker, Ine, Izamis, Maria-Louisa, Averkiou, Michalakis A

“…Abstract Localized drug delivery and uptake can benefit from the combined action of ultrasound and microbubbles at a specific site. Some of the possible…”
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Fluorine MR Imaging Probes Dynamic Migratory Profiles of Perfluorocarbon-Loaded Dendritic Cells After Streptozotocin-Induced Inflammation by Saini, Shweta, Vanherwegen, An-Sofie, Liang, Sayuan, Verbeke, Rein, Korf, Hannelie, Lentacker, Ine, De Smedt, Stefaan C., Gysemans, Conny, Himmelreich, Uwe

“…Purpose The pathogenesis of type 1 diabetes (T1D) involves presentation of islet-specific self-antigens by dendritic cells (DCs) to autoreactive T cells,…”
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Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon by Broos, Katrijn, Van der Jeught, Kevin, Puttemans, Janik, Goyvaerts, Cleo, Heirman, Carlo, Dewitte, Heleen, Verbeke, Rein, Lentacker, Ine, Thielemans, Kris, Breckpot, Karine

“…Cancer vaccines based on mRNA are extensively studied. The fragile nature of mRNA has instigated research into carriers that can protect it from ribonucleases…”
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mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice by Van Hoecke, Lien, Verbeke, Rein, De Vlieger, Dorien, Dewitte, Heleen, Roose, Kenny, Van Nevel, Sharon, Krysko, Olga, Bachert, Claus, Schepens, Bert, Lentacker, Ine, Saelens, Xavier

“…To date, mRNA-based biologics have mainly been developed for prophylactic and therapeutic vaccination to combat infectious diseases or cancer. In the past…”
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In vitro methods to study bubble-cell interactions: Fundamentals and therapeutic applications by Lajoinie, Guillaume, De Cock, Ine, Coussios, Constantin C., Lentacker, Ine, Le Gac, Séverine, Stride, Eleanor, Versluis, Michel

“…Besides their use as contrast agents for ultrasound imaging, microbubbles are increasingly studied for a wide range of therapeutic applications. In particular,…”
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Non-spherical oscillations drive the ultrasound-mediated release from targeted microbubbles by Lajoinie, Guillaume, Luan, Ying, Gelderblom, Erik, Dollet, Benjamin, Mastik, Frits, Dewitte, Heleen, Lentacker, Ine, de Jong, Nico, Versluis, Michel

“…Ultrasound-driven microbubbles are attractive for a variety of applications in medicine, including real-time organ perfusion imaging and targeted molecular…”
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Theranostic mRNA-loaded microbubbles in the lymphatics of dogs: implications for drug delivery by Dewitte, Heleen, Vanderperren, Katrien, Haers, Hendrik, Stock, Emmelie, Duchateau, Luc, Hesta, Myriam, Saunders, Jimmy H, De Smedt, Stefaan C, Lentacker, Ine

“…Microbubbles have shown potential as intralymphatic ultrasound contrast agents while nanoparticle-loaded microbubbles are increasingly investigated for…”
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Acoustical Properties of Individual Liposome-Loaded Microbubbles by Luan, Ying, Faez, Telli, Gelderblom, Erik, Skachkov, Ilya, Geers, Bart, Lentacker, Ine, van der Steen, Ton, Versluis, Michel, de Jong, Nico

“…Abstract A comparison between phospholipid-coated microbubbles with and without liposomes attached to the microbubble surface was performed using the…”
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Evaluation of Liposome-Loaded Microbubbles as a Theranostic Tool in a Murine Collagen-Induced Arthritis Model by Deprez, Joke, Roovers, Silke, Lajoinie, Guillaume, Dewitte, Heleen, Decruy, Tine, Coudenys, Julie, Descamps, Benedicte, Vanhove, Christian, Versluis, Michel, Elewaut, Dirk, Jacques, Peggy, De Smedt, Stefaan C., Lentacker, Ine

“…Rheumatoid arthritis (RA) is an autoimmune disease characterized by severe inflammation of the synovial tissue. Here, we assess the feasibility of…”
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