Search Results - "Lenski, Richard E"

Experimental evolution and the dynamics of adaptation and genome evolution in microbial populations by Lenski, Richard E

“…Evolution is an on-going process, and it can be studied experimentally in organisms with rapid generations. My team has maintained 12 populations of…”
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Contingency and determinism in evolution: Replaying life's tape by Blount, Zachary D, Lenski, Richard E, Losos, Jonathan B

“…Historical processes display some degree of "contingency," meaning their outcomes are sensitive to seemingly inconsequential events that can fundamentally…”
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What is adaptation by natural selection? Perspectives of an experimental microbiologist by Lenski, Richard E

“…Ever since Darwin, the role of natural selection in shaping the morphological, physiological, and behavioral adaptations of animals and plants across…”
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Long-Term Dynamics of Adaptation in Asexual Populations by Wiser, Michael J., Ribeck, Noah, Lenski, Richard E.

“…Experimental studies of evolution have increased greatly in number in recent years, stimulated by the growing power of genomic tools. However, organismal…”
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The dynamics of molecular evolution over 60,000 generations by Good, Benjamin H., McDonald, Michael J., Barrick, Jeffrey E., Lenski, Richard E., Desai, Michael M.

“…The outcomes of evolution are determined by a stochastic dynamical process that governs how mutations arise and spread through a population. However, it is…”
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The Black Queen Hypothesis: evolution of dependencies through adaptive gene loss by Morris, J Jeffrey, Lenski, Richard E, Zinser, Erik R

“…Reductive genomic evolution, driven by genetic drift, is common in endosymbiotic bacteria. Genome reduction is less common in free-living organisms, but it has…”
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Genomic analysis of a key innovation in an experimental Escherichia coli population by Blount, Zachary D., Barrick, Jeffrey E., Davidson, Carla J., Lenski, Richard E.

“…Evolutionary novelties have been important in the history of life, but their origins are usually difficult to examine in detail. We previously described the…”
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A Comparison of Methods to Measure Fitness in Escherichia coli by Wiser, Michael J, Lenski, Richard E

“…In order to characterize the dynamics of adaptation, it is important to be able to quantify how a population's mean fitness changes over time. Such…”
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Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli by Blount, Zachary D, Borland, Christina Z, Lenski, Richard E

“…The role of historical contingency in evolution has been much debated, but rarely tested. Twelve initially identical populations of Escherichia coli were…”
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Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population by Khan, Aisha I., Dinh, Duy M., Schneider, Dominique, Lenski, Richard E., Cooper, Tim F.

“…Epistatic interactions between mutations play a prominent role in evolutionary theories. Many studies have found that epistasis is widespread, but they have…”
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Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria by Consuegra, Jessika, Gaffé, Joël, Lenski, Richard E., Hindré, Thomas, Barrick, Jeffrey E., Tenaillon, Olivier, Schneider, Dominique

“…Insertion sequences (IS) are ubiquitous bacterial mobile genetic elements, and the mutations they cause can be deleterious, neutral, or beneficial. The…”
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Repeatability and Contingency in the Evolution of a Key Innovation in Phage Lambda by Meyer, Justin R., Dobias, Devin T., Weitz, Joshua S., Barrick, Jeffrey E., Quick, Ryan T., Lenski, Richard E.

“…The processes responsible for the evolution of key innovations, whereby lineages acquire qualitatively new functions that expand their ecological…”
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Analysis of bacterial genomes from an evolution experiment with horizontal gene transfer shows that recombination can sometimes overwhelm selection by Maddamsetti, Rohan, Lenski, Richard E

“…Few experimental studies have examined the role that sexual recombination plays in bacterial evolution, including the effects of horizontal gene transfer on…”
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Coevolution drives the emergence of complex traits and promotes evolvability by Zaman, Luis, Meyer, Justin R, Devangam, Suhas, Bryson, David M, Lenski, Richard E, Ofria, Charles

“…The evolution of complex organismal traits is obvious as a historical fact, but the underlying causes--including the role of natural selection--are contested…”
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Historical contingency in the evolution of antibiotic resistance after decades of relaxed selection by Card, Kyle J, LaBar, Thomas, Gomez, Jasper B, Lenski, Richard E

“…Populations often encounter changed environments that remove selection for the maintenance of particular phenotypic traits. The resulting genetic decay of…”
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Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load by Wielgoss, Sébastien, Barrick, Jeffrey E., Tenaillon, Olivier, Wiser, Michael J., Dittmar, W. James, Cruveiller, Stéphane, Chane-Woon-Ming, Béatrice, Médigue, Claudine, Lenski, Richard E., Schneider, Dominique

“…Mutations are the ultimate source of heritable variation for evolution. Understanding how mutation rates themselves evolve is thus essential for quantitatively…”
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experimental test of evolutionary trade-offs during temperature adaptation by Bennett, Albert F, Lenski, Richard E

“…We used experimental evolution to test directly the important and commonplace evolutionary hypothesis that adaptation, increased fitness within the selective…”
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Changes in Intrinsic Antibiotic Susceptibility during a Long-Term Evolution Experiment with Escherichia coli by Lamrabet, Otmane, Martin, Mikaël, Lenski, Richard E, Schneider, Dominique

“…High-level resistance often evolves when populations of bacteria are exposed to antibiotics, by either mutations or horizontally acquired genes. There is also…”
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Experiments on the role of deleterious mutations as stepping stones in adaptive evolution by Covert, 3rd, Arthur W, Lenski, Richard E, Wilke, Claus O, Ofria, Charles

“…Many evolutionary studies assume that deleterious mutations necessarily impede adaptive evolution. However, a later mutation that is conditionally beneficial…”
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Environmental and Physiological Factors Affecting High-Throughput Measurements of Bacterial Growth by Atolia, Esha, Cesar, Spencer, Arjes, Heidi A, Rajendram, Manohary, Shi, Handuo, Knapp, Benjamin D, Khare, Somya, Aranda-Díaz, Andrés, Lenski, Richard E, Huang, Kerwyn Casey

“…Bacterial growth under nutrient-rich and starvation conditions is intrinsically tied to the environmental history and physiological state of the population…”
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