Search Results - "Lenser, Melina"

Evaluation of two transposases for improving expression of recombinant proteins in Chinese hamster ovary cell stable pools by co-transfection and supertransfection approaches by Lenser, Melina, Ngo, Hanh Giai, Sarrafha, Lily, Rajendra, Yashas

“…Transposons are genetic elements capable of cutting and pasting genes of interest via the action of a transposase and offer many advantages over random or…”
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TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge by Nugent, Alicia A., Lin, Karin, van Lengerich, Bettina, Lianoglou, Steve, Przybyla, Laralynne, Davis, Sonnet S., Llapashtica, Ceyda, Wang, Junhua, Kim, Do Jin, Xia, Dan, Lucas, Anthony, Baskaran, Sulochanadevi, Haddick, Patrick C.G., Lenser, Melina, Earr, Timothy K., Shi, Ju, Dugas, Jason C., Andreone, Benjamin J., Logan, Todd, Solanoy, Hilda O., Chen, Hang, Srivastava, Ankita, Poda, Suresh B., Sanchez, Pascal E., Watts, Ryan J., Sandmann, Thomas, Astarita, Giuseppe, Lewcock, Joseph W., Monroe, Kathryn M., Di Paolo, Gilbert

“…Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in microglia, increase Alzheimer’s disease risk. TREM2 senses lipids and mediates myelin…”
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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic by Logan, Todd, Simon, Matthew J., Rana, Anil, Cherf, Gerald M., Srivastava, Ankita, Davis, Sonnet S., Low, Ray Lieh Yoon, Chiu, Chi-Lu, Fang, Meng, Huang, Fen, Bhalla, Akhil, Llapashtica, Ceyda, Prorok, Rachel, Pizzo, Michelle E., Calvert, Meredith E.K., Sun, Elizabeth W., Hsiao-Nakamoto, Jennifer, Rajendra, Yashas, Lexa, Katrina W., Srivastava, Devendra B., van Lengerich, Bettina, Wang, Junhua, Robles-Colmenares, Yaneth, Kim, Do Jin, Duque, Joseph, Lenser, Melina, Earr, Timothy K., Nguyen, Hoang, Chau, Roni, Tsogtbaatar, Buyankhishig, Ravi, Ritesh, Skuja, Lukas L., Solanoy, Hilda, Rosen, Howard J., Boeve, Bradley F., Boxer, Adam L., Heuer, Hilary W., Dennis, Mark S., Kariolis, Mihalis S., Monroe, Kathryn M., Przybyla, Laralynne, Sanchez, Pascal E., Meisner, Rene, Diaz, Dolores, Henne, Kirk R., Watts, Ryan J., Henry, Anastasia G., Gunasekaran, Kannan, Astarita, Giuseppe, Suh, Jung H., Lewcock, Joseph W., DeVos, Sarah L., Di Paolo, Gilbert

“…GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lysosomal and secreted protein with unclear function. Here, we…”
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A brain penetrant progranulin biotherapeutic rescues lysosomal and inflammatory phenotypes in the brain of GRN knockout mice by Logan, Todd, DeVos, Sarah, Simon, Matthew J., Davis, Sonnet, Wang, Junhua, Low, Ray, Huang, Fen, Rajendra, Yashas, Prorok, Rachel, Sun, Elizabeth, Rana, Anil, Hsiao‐Nakamoto, Jennifer, Mosesova, Sofia, Zhu, Yuda, Cherf, Gerald M., Lengerich, Bettina, Bhalla, Akhil, Kim, Do Jin, Chan, Darren, Duque, Joseph, Tran, Hai, Lenser, Melina, Nguyen, Hoang, Chau, Roni, Earr, Timothy, Kariolis, Mihalis S., Monroe, Kathryn M., Sanchez, Pascal E., Dennis, Mark S., Henne, Kirk R., Gunasekaran, Kannan, Astarita, Giuseppe, Watts, Ryan J., Sweeney, Zachary K., Lewcock, Joseph W., Srivastava, Ankita, Di Paolo, Gilbert

“…Background Heterozygous loss of function (LOF) mutations in GRN cause frontotemporal dementia (FTD), a neurodegenerative disorder associated with lysosomal…”
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A brain penetrant progranulin biotherapeutic rescues lysosomal and inflammatory phenotypes in the brain of GRN knockout mice: Lipids in AD and FTD: From genes to interventions by Logan, Todd, DeVos, Sarah, Simon, Matthew J., Davis, Sonnet, Wang, Junhua, Low, Ray, Huang, Fen, Rajendra, Yashas, Prorok, Rachel, Sun, Elizabeth, Rana, Anil, Hsiao‐Nakamoto, Jennifer, Mosesova, Sofia, Zhu, Yuda, Cherf, Gerald M., Lengerich, Bettina, Bhalla, Akhil, Kim, Do Jin, Chan, Darren, Duque, Joseph, Tran, Hai, Lenser, Melina, Nguyen, Hoang, Chau, Roni, Earr, Timothy, Kariolis, Mihalis S., Monroe, Kathryn M., Sanchez, Pascal E., Dennis, Mark S., Henne, Kirk R., Gunasekaran, Kannan, Astarita, Giuseppe, Watts, Ryan J., Sweeney, Zachary K., Lewcock, Joseph W., Srivastava, Ankita, Di Paolo, Gilbert

“…Abstract Background Heterozygous loss of function (LOF) mutations in GRN cause frontotemporal dementia (FTD), a neurodegenerative disorder associated with…”
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Phenotypic and molecular characterization of invasive serogroup W135 Neisseria meningitidis strains from 1990 to 2005 in Brazil by Lemos, Ana Paula S, Harrison, Lee H, Lenser, Melina, Sacchi, Claudio T

“…Summary Objective Neisseria meningitidis serogroup W135 has been associated with global outbreaks since the 2000 Hajj. Considering that N. meningitidis…”
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