Search Results - "Lenschow, Deborah J"

The microbial metabolite desaminotyrosine protects from influenza through type I interferon by Steed, Ashley L., Christophi, George P., Kaiko, Gerard E., Sun, Lulu, Goodwin, Victoria M., Jain, Umang, Esaulova, Ekaterina, Artyomov, Maxim N., Morales, David J., Holtzman, Michael J., Boon, Adrianus C. M., Lenschow, Deborah J., Stappenbeck, Thaddeus S.

“…The microbiota is known to modulate the host response to influenza infection through as-yet-unclear mechanisms. We hypothesized that components of the…”
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Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen by Burt, Felicity J, Prof, Chen, Weiqiang, PhD, Miner, Jonathan J, MD, Lenschow, Deborah J, MD, Merits, Andres, Prof, Schnettler, Esther, PhD, Kohl, Alain, PhD, Rudd, Penny A, PhD, Taylor, Adam, PhD, Herrero, Lara J, PhD, Zaid, Ali, PhD, Ng, Lisa F P, Prof, Mahalingam, Suresh, Prof

“…Summary Re-emergence of chikungunya virus, a mosquito-transmitted pathogen, is of serious public health concern. In the past 15 years, after decades of…”
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Identification of a candidate therapeutic autophagy-inducing peptide by Shoji-Kawata, Sanae, Sumpter, Rhea, Leveno, Matthew, Campbell, Grant R., Zou, Zhongju, Kinch, Lisa, Wilkins, Angela D., Sun, Qihua, Pallauf, Kathrin, MacDuff, Donna, Huerta, Carlos, Virgin, Herbert W., Helms, J. Bernd, Eerland, Ruud, Tooze, Sharon A., Xavier, Ramnik, Lenschow, Deborah J., Yamamoto, Ai, King, David, Lichtarge, Olivier, Grishin, Nick V., Spector, Stephen A., Kaloyanova, Dora V., Levine, Beth

“…The lysosomal degradation pathway of autophagy has a crucial role in defence against infection, neurodegenerative disorders, cancer and ageing. Accordingly,…”
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Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins by Swaim, Caleb D., Canadeo, Larissa A., Monte, Kristen J., Khanna, Swati, Lenschow, Deborah J., Huibregtse, Jon M.

“…ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the LFA-1 integrin to promote interferon (IFN)-γ release from natural…”
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Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I interferon response and alters influenza A virus pathogenesis by Hiller, Bradley E, Yin, Yongjun, Perng, Yi-Chieh, de Araujo Castro, Ítalo, Fox, Lindsey E, Locke, Marissa C, Monte, Kristen J, López, Carolina B, Ornitz, David M, Lenschow, Deborah J

“…Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the…”
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Context Is Key: Delineating the Unique Functions of IFNα and IFNβ in Disease by Fox, Lindsey E, Locke, Marissa C, Lenschow, Deborah J

“…Type I interferons (IFNs) are critical effector cytokines of the immune system and were originally known for their important role in protecting against viral…”
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Chikungunya virus-induced autophagy delays caspase-dependent cell death by Joubert, Pierre-Emmanuel, Werneke, Scott W, de la Calle, Claire, Guivel-Benhassine, Florence, Giodini, Alessandra, Peduto, Lucie, Levine, Beth, Schwartz, Olivier, Lenschow, Deborah J, Albert, Matthew L

“…Autophagy is an important survival pathway and can participate in the host response to infection. Studying Chikungunya virus (CHIKV), the causative agent of a…”
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ISG15 deficiency and increased viral resistance in humans but not mice by Speer, Scott D., Li, Zhi, Buta, Sofija, Payelle-Brogard, Béatrice, Qian, Li, Vigant, Frederic, Rubino, Erminia, Gardner, Thomas J., Wedeking, Tim, Hermann, Mark, Duehr, James, Sanal, Ozden, Tezcan, Ilhan, Mansouri, Nahal, Tabarsi, Payam, Mansouri, Davood, Francois-Newton, Véronique, Daussy, Coralie F., Rodriguez, Marisela R., Lenschow, Deborah J., Freiberg, Alexander N., Tortorella, Domenico, Piehler, Jacob, Lee, Benhur, García-Sastre, Adolfo, Pellegrini, Sandra, Bogunovic, Dusan

“…ISG15 is an interferon (IFN)-α/β-induced ubiquitin-like protein. It exists as a free molecule, intracellularly and extracellularly, and conjugated to target…”
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ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells by Bhushan, Jaya, Radke, Joshua B, Perng, Yi-Chieh, Mcallaster, Michael, Lenschow, Deborah J, Virgin, Herbert W, Sibley, L David

“…The intracellular protozoan parasite is capable of infecting most nucleated cells, where it survives in a specially modified compartment called the…”
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ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation by Werneke, Scott W, Schilte, Clementine, Rohatgi, Anjali, Monte, Kristen J, Michault, Alain, Arenzana-Seisdedos, Fernando, Vanlandingham, Dana L, Higgs, Stephen, Fontanet, Arnaud, Albert, Matthew L, Lenschow, Deborah J

“…Chikungunya virus (CHIKV) is a re-emerging alphavirus that has caused significant disease in the Indian Ocean region since 2005. During this outbreak, in…”
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Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance by Ketscher, Lars, Hannß, Ronny, Morales, David J., Basters, Anja, Guerra, Susana, Goldmann, Tobias, Hausmann, Annika, Prinz, Marco, Naumann, Ronald, Pekosz, Andrew, Utermöhlen, Olaf, Lenschow, Deborah J., Knobeloch, Klaus-Peter

“…Significance Viral infections still constitute a major health issue. Upon viral infection, interferon (IFN) elicits an antiviral response by activating…”
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Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent RNA by Young, Alissa R, Locke, Marissa C, Cook, Lindsey E, Hiller, Bradley E, Zhang, Rong, Hedberg, Matthew L, Monte, Kristen J, Veis, Deborah J, Diamond, Michael S, Lenschow, Deborah J

“…Chikungunya virus (CHIKV) is an arthritogenic alphavirus that acutely causes fever as well as severe joint and muscle pain. Chronic musculoskeletal pain…”
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Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell Death by Kulkarni, Hrishikesh S, Elvington, Michelle L, Perng, Yi-Chieh, Liszewski, M Kathryn, Byers, Derek E, Farkouh, Christopher, Yusen, Roger D, Lenschow, Deborah J, Brody, Steven L, Atkinson, John P

“…The complement system provides host defense against pathogens and environmental stress. C3, the central component of complement, is present in the blood and…”
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ISG15 functions as an interferon-mediated antiviral effector early in the murine norovirus life cycle by Rodriguez, Marisela R, Monte, Kristen, Thackray, Larissa B, Lenschow, Deborah J

“…Human noroviruses (HuNoV) are the leading cause of nonbacterial gastroenteritis worldwide. Similar to HuNoV, murine noroviruses (MNV) are enteric pathogens…”
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IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses by Lenschow, Deborah J, Lai, Caroline, Frias-Staheli, Natalia, Giannakopoulos, Nadia V, Lutz, Andrew, Wolff, Thorsten, Osiak, Anna, Levine, Beth, Schmidt, Robert E, García-Sastre, Adolfo, Leib, David A, Pekosz, Andrew, Knobeloch, Klaus-Peter, Horak, Ivan, Virgin, Herbert Whiting IV

“…Type I interferons (IFNs) play an essential role in the host response to viral infection through the induction of numerous IFN-stimulated genes (ISGs),…”
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Type I Interferons Link Viral Infection to Enhanced Epithelial Turnover and Repair by Sun, Lulu, Miyoshi, Hiroyuki, Origanti, Sofia, Nice, Timothy J., Barger, Alexandra C., Manieri, Nicholas A., Fogel, Leslie A., French, Anthony R., Piwnica-Worms, David, Piwnica-Worms, Helen, Virgin, Herbert W., Lenschow, Deborah J., Stappenbeck, Thaddeus S.

“…The host immune system functions constantly to maintain chronic commensal and pathogenic organisms in check. The consequences of these immune responses on host…”
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Cutting edge: paradoxical roles of BST2/tetherin in promoting type I IFN response and viral infection by Swiecki, Melissa, Wang, Yaming, Gilfillan, Susan, Lenschow, Deborah J, Colonna, Marco

“…Bone marrow stromal Ag 2 (BST2) is a transmembrane protein that prevents virus release from infected cells. It was also reported that BST2 inhibits type I IFN…”
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Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses by Frias-Staheli, Natalia, Giannakopoulos, Nadia V, Kikkert, Marjolein, Taylor, Shannon L, Bridgen, Anne, Paragas, Jason, Richt, Juergen A, Rowland, Raymond R, Schmaljohn, Connie S, Lenschow, Deborah J, Snijder, Eric J, García-Sastre, Adolfo, Virgin, 4th, Herbert Whiting

“…Ubiquitin (Ub) and interferon-stimulated gene product 15 (ISG15) reversibly conjugate to proteins and mediate important innate antiviral responses. The ovarian…”
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ISG15 in antiviral immunity and beyond by Perng, Yi-Chieh, Lenschow, Deborah J.

“…The host response to viral infection includes the induction of type I interferons and the subsequent upregulation of hundreds of interferon-stimulated genes…”
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Replication-competent fluorescent-expressing influenza B virus by Nogales, Aitor, Rodríguez-Sánchez, Irene, Monte, Kristen, Lenschow, Deborah J., Perez, Daniel R., Martínez-Sobrido, Luis

“…•We have generated replication-competent IBV expressing fluorescent proteins.•Fluorescent-expressing IBV display similar growth kinetics than wild-type…”
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