Search Results - "Lensch, M"

Disease-Specific Induced Pluripotent Stem Cells by Park, In-Hyun, Arora, Natasha, Huo, Hongguang, Maherali, Nimet, Ahfeldt, Tim, Shimamura, Akiko, Lensch, M. William, Cowan, Chad, Hochedlinger, Konrad, Daley, George Q.

“…Tissue culture of immortal cell strains from diseased patients is an invaluable resource for medical research but is largely limited to tumor cell lines or…”
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Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells by Kim, Kitai, Zhao, Rui, Doi, Akiko, Ng, Kitwa, Unternaehrer, Juli, Cahan, Patrick, Hongguang, Huo, Loh, Yuin-Han, Aryee, Martin J, Lensch, M William, Li, Hu, Collins, James J, Feinberg, Andrew P, Daley, George Q

“…Mouse induced pluripotent stem (iPS) cells have been shown to retain an epigenetic 'memory' of their cell type of origin. Kim et al . study this question in…”
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Hallmarks of pluripotency by De Los Angeles, Alejandro, Ferrari, Francesco, Xi, Ruibin, Fujiwara, Yuko, Benvenisty, Nissim, Deng, Hongkui, Hochedlinger, Konrad, Jaenisch, Rudolf, Lee, Soohyun, Leitch, Harry G., Lensch, M. William, Lujan, Ernesto, Pei, Duanqing, Rossant, Janet, Wernig, Marius, Park, Peter J., Daley, George Q.

“…In response to the need for a defined set of criteria to assess stem-cell potency, this review proposes guidelines for the evaluation of newly derived…”
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Reprogramming of T Cells from Human Peripheral Blood by Loh, Yuin-Han, Hartung, Odelya, Li, Hu, Guo, Chunguang, Sahalie, Julie M., Manos, Philip D., Urbach, Achia, Heffner, Garrett C., Grskovic, Marica, Vigneault, Francois, Lensch, M. William, Park, In-Hyun, Agarwal, Suneet, Church, George M., Collins, James J., Irion, Stefan, Daley, George Q.

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Reprogramming of human somatic cells to pluripotency with defined factors by Daley, George Q, Park, In-Hyun, Zhao, Rui, West, Jason A, Yabuuchi, Akiko, Huo, Hongguang, Ince, Tan A, Lerou, Paul H, Lensch, M. William

“…Pluripotency pertains to the cells of early embryos that can generate all of the tissues in the organism. Embryonic stem cells are embryo-derived cell lines…”
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Pluripotent Stem Cell Models of Shwachman-Diamond Syndrome Reveal a Common Mechanism for Pancreatic and Hematopoietic Dysfunction by Tulpule, Asmin, Kelley, James M., Lensch, M. William, McPherson, Jade, Park, In Hyun, Hartung, Odelya, Nakamura, Tomoka, Schlaeger, Thorsten M., Shimamura, Akiko, Daley, George Q.

“…Shwachman-Diamond syndrome (SDS), a rare autosomal-recessive disorder characterized by exocrine pancreatic insufficiency and hematopoietic dysfunction, is…”
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LIF/STAT3 Signaling Fails to Maintain Self‐Renewal of Human Embryonic Stem Cells by Dahéron, Laurence, Opitz, Sarah L., Zaehres, Holm, Lensch, William M., Andrews, Peter W., Itskovitz‐Eldor, Joseph, Daley, George Q.

“…Murine embryonic stem (mES) cells remain undifferentiated in the presence of leukemia inhibitory factor (LIF), and activation of signal transducer and…”
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Biomechanical forces promote embryonic haematopoiesis by Wenzel, Pamela L, Yoder, Mervin C, Naveiras, Olaia, Lensch, M. William, Daley, George Q, McKinney-Freeman, Shannon, García-Cardeña, Guillermo, Mack, Peter J, Suchy-Dicey, Astrid, Gracia-Sancho, Jorge, Yoshimoto, Momoko, Adamo, Luigi

“…Biomechanical forces are emerging as critical regulators of embryogenesis, particularly in the developing cardiovascular system. After initiation of the…”
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Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage by Tulpule, Asmin, Lensch, M. William, Miller, Justine D., Austin, Karyn, D'Andrea, Alan, Schlaeger, Thorsten M., Shimamura, Akiko, Daley, George Q.

“…Fanconi anemia (FA) is a genetically heterogeneous, autosomal recessive disorder characterized by pediatric bone marrow failure and congenital anomalies. The…”
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Investigating monogenic and complex diseases with pluripotent stem cells by Daley, George Q, Zhu, Hao, Lensch, M. William, Cahan, Patrick

“…Key Points Human genetic studies have revealed the molecular basis of countless monogenic diseases but have been less successful in dissecting complex…”
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Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1 by Baek, Kwan-Hyuck, Aird, William C, Okada, Yoshiaki, Siarey, Richard J, Minami, Takashi, Daley, George Q, Ryeom, Sandra, Lynch, Ryan C, Park, In-Hyun, Folkman, Judah, Zaslavsky, Alexander, Lensch, M. William, Yoon, Sam S, Korenberg, Julie R, Britt, Carmella, Galdzicki, Zygmunt

“…The incidence of many cancer types is significantly reduced in individuals with Down's syndrome, and it is thought that this broad cancer protection is…”
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High‐Efficiency RNA Interference in Human Embryonic Stem Cells by Zaehres, Holm, Lensch, M. William, Daheron, Laurence, Stewart, Sheila A., Itskovitz‐Eldor, Joseph, Daley, George Q.

“…RNA interference methodology suppresses gene expression, thus mimicking loss‐of‐function mutation and enabling in vitro and in vivo gene function analysis. In…”
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Broader Implications of Defining Standards for the Pluripotency of iPSCs by Daley, George Q., Lensch, M. William, Jaenisch, Rudolf, Meissner, Alex, Plath, Kathrin, Yamanaka, Shinya

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William A. Hinton (1883–1959): Diagnosing and Confronting Racism in the Medical Profession by Rodríguez, Ángel, Lensch, M. William, Podolsky, Scott H.

“…Racism impacts every aspect of medicine, including the careers and lives of Black physicians. The story of William Augustus Hinton (1883–1959), who invented…”
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Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition by Kim, Peter Geon, Albacker, Colleen E, Lu, Yi-fen, Jang, Il-ho, Lim, Yoowon, Heffner, Garrett C, Arora, Natasha, Bowman, Teresa V, Lin, Michelle I, Lensch, M William, De Los Angeles, Alejandro, Zon, Leonard I, Loewer, Sabine, Daley, George Q

“…During development, the hematopoietic lineage transits through hemogenic endothelium, but the signaling pathways effecting this transition are incompletely…”
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Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera by Lensch, M William, Schlaeger, Thorsten M, Zon, Leonard I, Daley, George Q

“…Despite a long and valuable history, human-animal chimera research has often been questioned. Among the moral issues raised by chimeras is the concept that…”
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An Evolving Model of Hematopoietic Stem Cell Functional Identity by Lensch, M. William

“…Easily accessed via venipuncture, blood has been an object of study for centuries. Direct sampling of the hematopoietic tissues in the bone marrow also…”
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From Stealing Fire to Cellular Reprogramming: A Scientific History Leading to the 2012 Nobel Prize by Lensch, M. William, Mummery, Christine L.

“…Cellular reprogramming was recently “crowned” with the award of the Nobel Prize to two of its groundbreaking researchers, Sir John Gurdon and Shinya Yamanaka…”
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Cellular reprogramming and pluripotency induction by Lensch, M. William

“…Introduction Cellular reprogramming is the process of directing mature cells to a primitive state of gene expression. Sources of data Medline searches using…”
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Gene-expression signature of adhesion/growth-regulatory tissue lectins (galectins) in transitional cell cancer and its prognostic relevance by Langbein, S, Brade, J, Badawi, J K, Hatzinger, M, Kaltner, H, Lensch, M, Specht, K, André, S, Brinck, U, Alken, P, Gabius, H-J

“…Aims:  Lectins, and especially galectins, appear to be important in malignancy‐associated processes. The aim was to analyse comprehensively the presence of…”
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