Search Results - "Lens, Susanne M.A"

Cell division: control of the chromosomal passenger complex in time and space by van der Horst, Armando, Lens, Susanne M.A

“…The ultimate goal of cell division is equal transmission of the duplicated genome to two new daughter cells. Multiple surveillance systems exist that monitor…”
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Functionality of the chromosomal passenger complex in cancer by Hindriksen, Sanne, Meppelink, Amanda, Lens, Susanne M A

“…The evolutionary conserved chromosomal passenger complex (CPC) is essential for faithful transmission of the genome during cell division. Perturbation of this…”
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A Positive Feedback Loop Involving Haspin and Aurora B Promotes CPC Accumulation at Centromeres in Mitosis by Wang, Fangwei, Ulyanova, Natalia P., van der Waal, Maike S., Patnaik, Debasis, Lens, Susanne M.A., Higgins, Jonathan M.G.

“…Haspin phosphorylates histone H3 at Thr3 (H3T3ph) during mitosis [1, 2], providing a chromatin binding site for the chromosomal passenger complex (CPC) at…”
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Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability by Hengeveld, Rutger C.C., de Boer, H. Rudolf, Schoonen, Pepijn M., de Vries, Elisabeth G.E., Lens, Susanne M.A., van Vugt, Marcel A.T.M.

“…Sister-chromatid disjunction in anaphase requires the resolution of DNA catenanes by topoisomerase II together with Plk1-interacting checkpoint helicase (PICH)…”
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chromosomal passenger complex: guiding Aurora-B through mitosis by Vader, Gerben, Medema, René H, Lens, Susanne M.A

“…During mitosis, the chromosomal passenger complex (CPC) orchestrates highly different processes, such as chromosome alignment, histone modification, and…”
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Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation by Meppelink, Amanda, Kabeche, Lilian, Vromans, Martijn J M, Compton, Duane A, Lens, Susanne M A

“…Correction of faulty kinetochore-microtubule attachments is essential for faithful chromosome segregation and dictated by the opposing activities of Aurora B…”
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Inter-domain Cooperation in INCENP Promotes Aurora B Relocation from Centromeres to Microtubules by van der Horst, Armando, Vromans, Martijn J.M., Bouwman, Kim, van der Waal, Maike S., Hadders, Michael A., Lens, Susanne M.A.

“…The chromosomal passenger complex is essential for error-free chromosome segregation and proper execution of cytokinesis. To coordinate nuclear division with…”
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Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension by Medema, René H, Lens, Susanne M.A, Wolthuis, Rob M.F, Klompmaker, Rob, Kauw, Jos, Agami, Reuven, Brummelkamp, Thijn, Kops, Geert

“…Genetic evidence is mounting that survivin plays a crucial role in mitosis, but its exact role in human cell division remains elusive. We show that mammalian…”
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The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions by Vader, Gerben, Cruijsen, Carin W A, van Harn, Tanja, Vromans, Martijn J M, Medema, René H, Lens, Susanne M A

“…The chromosomal passenger complex (CPC) is a critical regulator of chromosome segregation during mitosis by correcting nonbipolar microtubule-kinetochore…”
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The Aurora kinase family in cell division and cancer by Vader, Gerben, Lens, Susanne M.A.

“…The Aurora protein kinase family (consisting of Aurora-A, -B and -C) is an important group of enzymes that controls several aspects of cell division in…”
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Changing places: Chromosomal Passenger Complex relocation in early anaphase by Hadders, Michael A., Lens, Susanne M.A.

“…The Chromosomal Passenger Complex (CPC) regulates a plethora of processes during multiple stages of nuclear and cytoplasmic division. Early during mitosis, the…”
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Shared and separate functions of polo-like kinases and aurora kinases in cancer by Lens, Susanne M. A, Medema, René H, Voest, Emile E

“…Key Points The polo-like kinases 1–5 (PLK1–5), and aurora kinases, aurora kinase A, aurora kinase B and aurora kinase C have essential roles during cell…”
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Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis by Hadders, Michael A, Hindriksen, Sanne, Truong, My Anh, Mhaskar, Aditya N, Wopken, J Pepijn, Vromans, Martijn J M, Lens, Susanne M A

“…Aurora B kinase is essential for faithful chromosome segregation during mitosis. During (pro)metaphase, Aurora B is concentrated at the inner centromere by the…”
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Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics by DeLuca, Keith F, Meppelink, Amanda, Broad, Amanda J, Mick, Jeanne E, Peersen, Olve B, Pektas, Sibel, Lens, Susanne M A, DeLuca, Jennifer G

“…Precise regulation of kinetochore-microtubule attachments is essential for successful chromosome segregation. Central to this regulation is Aurora B kinase,…”
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Leave no sister behind by Hadders, Michael A., Lens, Susanne M.A.

“…Recent work published in Cell Reports and Developmental Cell from Sen et al., Orr et al., and Papini et al., demonstrates that midzone-based Aurora B resolves…”
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Sequential Multisite Phospho-Regulation of KNL1-BUB3 Interfaces at Mitotic Kinetochores by Vleugel, Mathijs, Omerzu, Manja, Groenewold, Vincent, Hadders, Michael A., Lens, Susanne M.A., Kops, Geert J.P.L.

“…Regulated recruitment of the kinase-adaptor complex BUB1/BUB3 to kinetochores is crucial for correcting faulty chromosome-spindle attachments and for spindle…”
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Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis by Saurin, Adrian T., van der Waal, Maike S., Medema, René H., Lens, Susanne M.A., Kops, Geert J.P.L.

“…The mitotic checkpoint prevents mitotic exit until all chromosomes are attached to spindle microtubules. Aurora B kinase indirectly invokes this checkpoint by…”
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Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment by Jelluma, Nannette, Brenkman, Arjan B., van den Broek, Niels J.F., Cruijsen, Carin W.A., van Osch, Maria H.J., Lens, Susanne M.A., Medema, René H., Kops, Geert J.P.L.

“…Maintenance of chromosomal stability relies on coordination between various processes that are critical for proper chromosome segregation in mitosis. Here we…”
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FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer by Tavares, Sandra, Liv, Nalan, Pasolli, Milena, Opdam, Mark, Rätze, Max A.K., Saornil, Manuel, Sluimer, Lilian M., Hengeveld, Rutger C.C., van Es, Robert, van Werkhoven, Erik, Vos, Harmjan, Rehmann, Holger, Burgering, Boudewijn M.T., Oosterkamp, Hendrika M., Lens, Susanne M.A., Klumperman, Judith, Linn, Sabine C., Derksen, Patrick W.B.

“…Elevated expression of non-receptor tyrosine kinase FER is an independent prognosticator that correlates with poor survival of high-grade and…”
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Mind the midzone by Hadders, Michael A., Lens, Susanne M.A.

“…Is the separation of chromosomes during cell division monitored by a checkpoint? [Also see Report by Afonso et al. ] When a eukaryotic cell divides, it must…”
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