Search Results - "Lens, S. M"

Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown by RODRIGUEZ, J. A, LENS, S. M. A, SPAN, S. W, VADER, G, MEDEMA, R. H, KRUYT, F. A. E, GIACCONE, G

“…As mitosis progresses, the chromosomal passenger proteins (CPPs) Survivin, Aurora B, INCENP and Borealin dynamically colocalize to mitotic structures…”
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Characterization of the human CD27 ligand, a novel member of the TNF gene family by Hintzen, RQ, Lens, SM, Beckmann, MP, Goodwin, RG, Lynch, D, van Lier, RA

“…CD27 is a lymphocyte-specific member of the TNF/NGF-R family that is highly induced on T cells after TCR stimulation, primarily on lymphocytes belonging to the…”
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Chromosome segregation regulation in human zygotes: altered mitotic histone phosphorylation dynamics underlying centromeric targeting of the chromosomal passenger complex by van de Werken, C., Avo Santos, M., Laven, J.S.E., Eleveld, C., Fauser, B.C.J.M., Lens, S.M.A., Baart, E.B.

“…STUDY QUESTION Are the kinase feedback loops that regulate activation and centromeric targeting of the chromosomal passenger complex (CPC), functional during…”
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Regulation of CD27 expression on subsets of mature T-lymphocytes by Hintzen, RQ, de Jong, R, Lens, SM, Brouwer, M, Baars, P, van Lier, RA

“…CD27, a lymphocyte-specific member of the TNF/NGF-R family, is expressed on the majority of peripheral blood T cells. Activation of T cells via TCR/CD3 induces…”
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A dual role for both CD40-ligand and TNF-alpha in controlling human B cell death by Lens, SM, Tesselaar, K, den Drijver, BF, van Oers, MH, van Lier, RA

“…Members of the TNF-R family are instrumental in controlling lymphoid cell death and survival. A major role in the regulation of murine and human B cell…”
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CD20-induced B cell death can bypass mitochondria and caspase activation by VAN DER KOLK, L. E, EVERS, L. M, OMENE, C, LENS, S. M. A, LEDERMAN, S, VAN LIER, R. A. W, VAN OERS, M. H. J, ELDERING, E

“…The apoptotic pathway activated by chimeric anti-CD20 monoclonal antibodies (rituximab, IDEC.C2B8) was analyzed using the Burkitt lymphoma cell line Ramos…”
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Aberrant expression and reverse signalling of CD70 on malignant B cells by Lens, Susanne M. A., Drillenburg, Paul, Den Drijver, Bianca F. A., Van Schijndel, Gijs, Pals, Steven T., Van Lier, René A. W., Van Oers, Marinus H. J.

“…In normal lymphoid tissues the tumour necrosis factor‐receptor family member CD27 and its ligand CD70 have a restricted expression pattern. Previously, we…”
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Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation by Hintzen, RQ, Lens, SM, Lammers, K, Kuiper, H, Beckmann, MP, van Lier, RA

“…Molecules of the TNF-R family have been shown to be essential in the regulation of lymphocyte growth and differentiation. The TNF-R family member CD27 binds to…”
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CD30 expression does not discriminate between human Th1- and Th2-type T cells by Hamann, D, Hilkens, CM, Grogan, JL, Lens, SM, Kapsenberg, ML, Yazdanbakhsh, M, van Lier, RA

“…CD30 is a member of the TNF receptor superfamily that is commonly used as a marker for Hodgkin and Reed-Sternberg cells in Hodgkin's disease. More recently, it…”
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CD70 represents the human ligand for CD27 by Hintzen, R Q, Lens, S M, Koopman, G, Pals, S T, Spits, H, van Lier, R A

“…The recently identified CD27 ligand (L) is a type II transmembrane molecule with significant structural homology to tumor necrosis factor (TNF)-alpha,…”
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Functional B cell abnormalities in HIV type 1 infection: role of CD40L and CD70 by Wolthers, K C, Otto, S A, Lens, S M, Van Lier, R A, Miedema, F, Meyaard, L

“…Early in HIV-1 infection, B cell responses to T cell-dependent antigens are impaired. In addition to the receptor-ligand pair CD40/CD40L, CD27/CD70 also…”
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Antigen-presenting cell-derived signals determine expression levels of CD70 on primed T cells by Lens, S M, Baars, P A, Hooibrink, B, van Oers, M H, van Lier, R A

“…Interaction between CD27 and its ligand CD70 provides a second signal for T-cell proliferation and tumour necrosis factor-alpha (TNF-alpha) production. Whereas…”
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Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension by Medema, René H, Lens, Susanne M.A, Wolthuis, Rob M.F, Klompmaker, Rob, Kauw, Jos, Agami, Reuven, Brummelkamp, Thijn, Kops, Geert

“…Genetic evidence is mounting that survivin plays a crucial role in mitosis, but its exact role in human cell division remains elusive. We show that mammalian…”
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Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant by Earnshaw, W. C, Allshire, R. C, Black, B. E, Bloom, K, Brinkley, B. R, Brown, W, Cheeseman, I. M, Choo, K. H. A, Copenhaver, G. P, DeLuca, J. G, Desai, A, Diekmann, S, Erhardt, S, Fitzgerald-Hayes, M, Foltz, D, Fukagawa, T, Gassmann, R, Gerlich, D. W, Glover, D. M, Gorbsky, G. J, Harrison, S. C, Heun, P, Hirota, T, Jansen, L. E. T, Karpen, G, Kops, G. J. P. L, Lampson, M. A, Lens, S. M, Losada, A, Luger, K, Maiato, H, Maddox, P. S, Margolis, R. L, Masumoto, H, McAinsh, A. D, Mellone, B. G, Meraldi, P, Musacchio, A, Oegema, K, O’Neill, R. J, Salmon, E. D, Scott, K. C, Straight, A. F, Stukenberg, P. T, Sullivan, B. A, Sullivan, K. F, Sunkel, C. E, Swedlow, J. R, Walczak, C. E, Warburton, P. E, Westermann, S, Willard, H. F, Wordeman, L, Yanagida, M, Yen, T. J, Yoda, K, Cleveland, D. W

“…The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from…”
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Control of lymphocyte function through CD27–CD70 interactions by Lens, Susanne M.A., Tesselaar, Kiki, van Oers, Marinus H.J., van Lier, René A.W.

“…In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High…”
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CD27: marker and mediator of T-cell activation? by Hintzen, R Q, de Jong, R, Lens, S M, van Lier, R A

“…CD27 is a lymphocyte-specific member of the tumour necrosis factor receptor (TNF-R) family, expression of which is tightly regulated during T-cell ontogeny…”
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Protein kinase A regulates expression of p27(kip1) and cyclin D3 to suppress proliferation of leukemic T cell lines by van Oirschot, B A, Stahl, M, Lens, S M, Medema, R H

“…Peripheral homeostasis and tolerance requires the suppression or removal of excessive or harmful T lymphocytes. This can occur either by apoptosis through…”
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Cytolytic Mechanisms and Expression of Activation-Regulating Receptors on Effector-Type CD8+CD45RA+CD27- Human T Cells by Baars, Paul A, Ribeiro do Couto, Laura M, Leusen, Jeanette H. W, Hooibrink, Berend, Kuijpers, Taco W, Lens, Susanne M. A, van Lier, Rene A. W

“…Circulating CD8+ T cells with a CD45RA+CD27- phenotype resemble cytolytic effector cells because they express various cytolytic mediators and are able to…”
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Increased expression of CD80, CD86 and CD70 on T cells from HIV-infected individuals upon activation in vitro: regulation by CD4+ T cells by Wolthers, K C, Otto, S A, Lens, S M, Kolbach, D N, van Lier, R A, Miedema, F, Meyaard, L

“…T cells express CD28 and CD27 which transduce co-stimulatory signals after interaction with their ligands on antigen-presenting cells (APC). These ligands,…”
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Phenotype and function of human B cells expressing CD70 (CD27 ligand) by Lens, S M, de Jong, R, Hooibrink, B, Koopman, G, Pals, S T, van Oers, M H, van Lier, R A

“…CD70, the cellular ligand of the tumor necrosis factor receptor family member CD27, can be found on a limited number of germinal center (GC) B cells in some…”
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