Search Results - "Lennox, Alastair J J"

Transmetalation in the Suzuki-Miyaura Coupling: The Fork in the Trail by Lennox, Alastair J. J., Lloyd-Jones, Guy C.

“…The Suzuki–Miyaura coupling is one of the few transition‐metal‐catalyzed CC bond‐forming reactions that have been used in applications ranging from discovery…”
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Electrode Materials in Modern Organic Electrochemistry by Heard, David M., Lennox, Alastair J. J.

“…The choice of electrode material is critical for achieving optimal yields and selectivity in synthetic organic electrochemistry. The material imparts…”
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Direct electrochemical hydrodefluorination of trifluoromethylketones enabled by non-protic conditions by Box, John R, Atkins, Alexander P, Lennox, Alastair J. J

“…CF 2 H groups are unique due to the combination of their lipophilic and hydrogen bonding properties. The strength of H-bonding is determined by the group to…”
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Electronically Ambivalent Hydrodefluorination of Aryl‐CF3 groups enabled by Electrochemical Deep‐Reduction on a Ni Cathode by Box, John R., Avanthay, Mickaël E., Poole, Darren L., Lennox, Alastair J. J.

“…The Ar‐CF2H moiety is featured in an increasing number of bioactive compounds due to its unique combination of properties. The hydrodefluorination of Ar‐CF3…”
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Electrochemical Aminoxyl-Mediated α‑Cyanation of Secondary Piperidines for Pharmaceutical Building Block Diversification by Lennox, Alastair J. J, Goes, Shannon L, Webster, Matthew P, Koolman, Hannes F, Djuric, Stevan W, Stahl, Shannon S

“…Secondary piperidines are ideal pharmaceutical building blocks owing to the prevalence of piperidines in commercial drugs. Here, we report an electrochemical…”
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Organotrifluoroborate Hydrolysis: Boronic Acid Release Mechanism and an Acid–Base Paradox in Cross-Coupling by Lennox, Alastair J. J, Lloyd-Jones, Guy C

“…The hydrolysis of potassium organotrifluoroborate (RBF3K) reagents to the corresponding boronic acids (RB(OH)2) has been studied in the context of their…”
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Unravelling the Mechanism of Basic Aqueous Methanol Dehydrogenation Catalyzed by Ru–PNP Pincer Complexes by Alberico, Elisabetta, Lennox, Alastair J. J, Vogt, Lydia K, Jiao, Haijun, Baumann, Wolfgang, Drexler, Hans-Joachim, Nielsen, Martin, Spannenberg, Anke, Checinski, Marek P, Junge, Henrik, Beller, Matthias

“…Ruthenium PNP complex 1a (RuH­(CO)­Cl­(HN­(C2H4Pi-Pr2)2)) represents a state-of-the-art catalyst for low-temperature (<100 °C) aqueous methanol dehydrogenation…”
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Intramolecular Alkene Fluoroarylation of Phenolic Ethers Enabled by Electrochemically Generated Iodane by Doobary, Sayad, Poole, Darren L, Lennox, Alastair J. J

“…The 3-substituted chromane core is found in several bioactive natural products. Herein, we describe a route to 3-fluorinated chromanes from allylic phenol…”
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Electrochemical synthesis of biaryls by reductive extrusion from N,N’-diarylureas by Stammers, Ellie, Parsons, Chris D., Clayden, Jonathan, Lennox, Alastair J. J.

“…The synthesis of biaryl compounds by the transition-metal free coupling of arenes is an important contemporary challenge, aiming to avoid the toxicity and cost…”
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Copper-Based Photosensitisers in Water Reduction: A More Efficient In Situ Formed System and Improved Mechanistic Understanding by Lennox, Alastair J. J., Fischer, Steffen, Jurrat, Mark, Luo, Shu-Ping, Rockstroh, Nils, Junge, Henrik, Ludwig, Ralf, Beller, Matthias

“…The reduction of water has been achieved through a non‐noble‐metal‐based homogeneous catalyst system that is formed in situ. Optimisation of the ligand…”
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Preparation of Organotrifluoroborate Salts: Precipitation-Driven Equilibrium under Non-Etching Conditions by Lennox, Alastair J. J., Lloyd-Jones, Guy C.

“…Simple, rapid, and scaleable: In contrast to current procedures using corrosive HF/MF or MHF2 reagents (M=e.g. K), a wide range of trifluoroborates can be…”
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Dichloromeldrum’s Acid (DiCMA): A Practical and Green Amine Dichloroacetylation Reagent by Heard, David M, Lennox, Alastair J. J

“…Dichloromeldrum’s acid is introduced as a bench-stable, nonvolatile reagent for the dichloroacetylation of anilines and alkyl amines to produce…”
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Aryl Trifluoroborates in Suzuki-Miyaura Coupling: The Roles of Endogenous Aryl Boronic Acid and Fluoride by Butters, Mike, Harvey, Jeremy N, Jover, Jesus, Lennox, Alastair J.J, Lloyd-Jones, Guy C, Murray, Paul M

“…Undercover agents: The biaryl coupling of an aryltrifluoroborate with an aryl bromide involves in situ hydrolysis of the boron reagent. The hydrolysis products…”
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Diastereodivergent nucleophile–nucleophile alkene chlorofluorination by Doobary, Sayad, Lacey, Andrew J. D., Sweeting, Stephen G., Coppock, Sarah B., Caldora, Henry P., Poole, Darren L., Lennox, Alastair J. J.

“…The selective hetero-dihalogenation of alkenes provides useful building blocks for a broad range of chemical applications. Unlike homo-dihalogenation,…”
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Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron‐Rich Substrates by Doobary, Sayad, Sedikides, Alexi T., Caldora, Henry P., Poole, Darren L., Lennox, Alastair J. J.

“…Fluorinated alkyl groups are important motifs in bioactive compounds, positively influencing pharmacokinetics, potency and conformation. The oxidative…”
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Selective electrochemical generation of benzylic radicals enabled by ferrocene-based electron-transfer mediators by Lennox, Alastair J J, Nutting, Jordan E, Stahl, Shannon S

“…The generation and intermolecular functionalisation of carbon-centred radicals has broad potential synthetic utility. Herein, we show that benzylic radicals…”
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Minimal manual input by Heard, David M., Lennox, Alastair J. J.

“…Synthetic organic chemistry is increasingly automated, data rich and intelligent. At the Automated Synthesis Forum, industry and academia showcased their…”
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Structure‐Activated Copper Photosensitisers for Photocatalytic Water Reduction by Chen, Nan‐Yu, Xia, Liang‐Min, Lennox, Alastair J. J., Sun, Yuan‐Yuan, Chen, Hao, Jin, Hai‐Ming, Junge, Henrik, Wu, Qin‐An, Jia, Jian‐Hong, Beller, Matthias, Luo, Shu‐Ping

“…A series of phenanthroline‐based ligands have been synthesised and their influence as bidentate nitrogen ligands in heteroleptic [Cu(P^P)(N^N)]+…”
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Benzylic C(sp 3 )-H fluorination by Atkins, Alexander P, Dean, Alice C, Lennox, Alastair J J

“…The selective fluorination of C(sp )-H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent…”
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Open‐ESyn: A 3D‐Printed Toolkit for Expanded ElectraSyn Functionality and Reproducibility for Electrosynthesis by Choi, Anthony, Heard, David M., Haydon, Calum S., Lennox, Alastair J. J.

“…Electrosynthetic reactions are performed in either custom‐made reactors that are developed and machined in‐house or commercially available systems that offer…”
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