Search Results - "Lennick, M."

A surrogate-based approach for post-genomic partner identification by Pillutla, R C, Hsiao, K, Brissette, R, Eder, P S, Giordano, T, Fletcher, P W, Lennick, M, Blume, A J, Goldstein, N I

“…Modern drug discovery is concerned with identification and validation of novel protein targets from among the 30,000 genes or more postulated to be present in…”
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Changes in the Hydrogen Exchange Kinetics of Escherichia coli Aspartate Transcarbamylase Produced by Effector Binding and Subunit Association by Lennick, M., Allewell, N. M.

“…Large changes in solvent accessibility to aspartate transcarbamylase (aspartate carbamoyltransferase, carbamoylphosphate:L-aspartate carbamoyltransferase, EC…”
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Kinetics of interaction of C1 inhibitor with C1.hivin.s by Lennick, M, Brew, S. A, Ingham, Kenneth C

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Assembly of High-Affinity Insulin Receptor Agonists and Antagonists from Peptide Building Blocks by Schäffer, Lauge, Brissette, Renee E., Spetzler, Jane C., Pillutla, Renuka C., Østergaard, Søren, Lennick, Michael, Brandt, Jakob, Fletcher, Paul W., Danielsen, Gillian M., Hsiao, Ku-Chuan, Andersen, Asser S., Dedova, Olga, Ribel, Ulla, Hoeg-Jensen, Thomas, Hansen, Per Hertz, Blume, Arthur J., Markussen, Jan, Goldstein, Neil I.

“…Insulin is thought to elicit its effects by crosslinking the two extracellular α-subunits of its receptor, thereby inducing a conformational change in the…”
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Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex by Kensil, C.R. (Cambridge Biotech Corporation, Worcester, MA), Patel, U, Lennick, M, Marciani, D

“…Saponins were purified from Quillaja saponaria Molina bark by silica and reverse phase chromatography. The resulting purified saponins were tested for adjuvant…”
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Peptides Identify the Critical Hotspots Involved in the Biological Activation of the Insulin Receptor by Pillutla, Renuka C., Hsiao, Ku-chuan, Beasley, James R., Brandt, Jakob, Østergaard, Søren, Hansen, Per Hertz, Spetzler, Jane C., Danielsen, Gillian M., Andersen, Asser S., Brissette, Renee E., Lennick, Michael, Fletcher, Paul W., Blume, Arthur J., Schäffer, Lauge, Goldstein, Neil I.

“…We used phage display to generate surrogate peptides that define the hotspots involved in protein-protein interaction between insulin and the insulin receptor…”
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Bohr effect of Escherichia coli aspartate transcarbamylase. Linkages between substrate binding, proton binding, and conformational transitions by Allewell, N. M, Hofmann, G. E, Zaug, A, Lennick, M

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Temporal expression of HIV-1 envelope proteins in baculovirus-infected insect cells: implications for glycosylation and CD4 binding by Murphy, C I, Lennick, M, Lehar, S M, Beltz, G A, Young, E

“…Three different human immunodeficiency virus type I (HIV-1) envelope derived recombinant proteins and the full length human CD4 polypeptide were expressed in…”
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Kinetics of interaction of C1 inhibitor with complement C1s by LENNICK, M, BREW, S. A, INGHAM, K. C

“…The kinetics of inhibition of the complement serine protease, C1s, by its only known inhibitor, C1 inhibitor, have been measured by a variety of methods. One…”
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Development of a Genetically-Engineered, Candidate Polio Vaccine Employing the Self-Assembling Properties of the Tobacco Mosaic Virus Coat Protein by Haynes, Joel R, Cunningham, Janet, von Seefried, Adolph, Lennick, Michael, Garvin, Robert T, Shen, Shi-Hsiang

“…A synthetic gene coding for the coat protein of tobacco mosaic virus (TMVCP) was expressed in under the direction of the UV5 promoter. Modification of the 3'…”
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Kinetics of interaction of C1 inhibitor with complement C1s super(-) by Lennick, M, Brew, SA, Ingham, K C

“…The kinetics of inhibition of the complement serine protease, C1s super(-), by its only known inhibitor, C1 inhibitor, have been measured by a variety of…”
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Changes in protein conformation and stability accompany complex formation between human C1 inhibitor and C1-s by Lennick, M, Brew, S A, Ingham, K C

“…The fluorescence spectrum of C1 inhibitor (C1-Inh) in aqueous buffer has a maximum at 324 nm which shifts to 358 nm in 6.0 M guanidinium chloride (GdmC1),…”
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Changes in protein conformation and stability accompany complex formation between human C1 inhibitor and C1s by LENNICK, M, BREW, S. A, INGHAM, K. C

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Changes in protein conformation and stability accompany complex formation between human C1 inhibitor and C1s super(-) by Lennick, M, Brew, SA, Ingham, K C

“…The fluorescence spectrum of C1 inhibitor (C1-Inh) in aqueous buffer has a maximum at 324 nm which shifts to 358 nm in 6.0 M guanidinium chloride (GdmCl),…”
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High-level expression of alpha-human atrial natriuretic peptide from multiple joined genes in Escherichia coli by Lennick, M, Haynes, J R, Shen, S H

“…A method is described which allows alpha-human atrial natriuretic peptide to be synthesized in stable form and with high yield in Escherichia coli. In the…”
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"WE KNEW THAT IF WE SUCCEEDED, WE COULD AT ONE BLOW DESTROY A CITY" by Lennick, Michael

“…Lennick interviews Edward Teller, Manhattan Project physicist and father of the hydrogen bomb. Among other things, Teller talks about his work in nuclear…”
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