Search Results - "Lennard, M.S"

Determination by liquid chromatography–mass spectrometry of clomiphene isomers in the plasma of patients undergoing treatment for the induction of ovulation by Crewe, H.K., Ghobadi, C., Gregory, A., Rostami-Hodjegan, A., Lennard, M.S.

“…A rapid, sensitive and selective LC–MS method is described for the simultaneous determination of zuclomiphene and enclomiphene in plasma from patients…”
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P.3.c.046 Zuclopenthixol interactions with paroxetine, fluoxetine, carbamazepine & levomepromazine in routine therapeutic monitoring by Davies, S.J.C, Westin, A.A, Castberg, I, Lewis, G, Lennard, M.S, Spigset, O

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Quantitative analysis of amitriptyline and nortriptyline in human plasma and liver microsomal preparations by high-performance liquid chromatography by Ghahramani, P., Lennard, M.S.

“…A simple, rapid, highly selective and sensitive method for the analysis of amitriptyline and nortriptyline in plasma and human liver microsomes is described…”
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An evaluation of cytochrome P450 isoform activities in the female dark agouti (DA) rat: relevance to its use as a model of the CYP2D6 poor metaboliser phenotype by Barham, H M, Lennard, M S, Tucker, G T

“…The female dark agouti (DA) rat lacks CYP2D1, the equivalent enzyme in the rat to human CYP2D6 (debrisoquine hydroxylase), and shows impaired metabolism of a…”
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Irreversible binding and metabolism of propranolol by human liver microsomes--relationship to polymorphic oxidation by Shaw, L, Lennard, M S, Tucker, G T, Bax, N D, Woods, H F

“…Studies were performed to investigate the irreversible binding and oxidative metabolism of propranolol in human liver microsomes and the relationship of…”
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Assessment of the mouse as an experimental model for studying polymorphic oxidation of the sparteine/debrisoquine type by Adams, M, Lennard, M S, Otton, S V, Tucker, G T, Woods, H F

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Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4 by Row, E.C., Brown, S.A., Stachulski, A.V., Lennard, M.S.

“…The inhibitory effect of a series of 8-geranylpsoralens ( 1), an analogue of the 5-substituted counterpart bergamottin ( 2), on human CYP3A4 activity is…”
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544 Metabolism of chlorpyrifos and diazinon by human liver microsomes by Sams, C., Cocker, J., Lennard, M.S.

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Metabolic abnormalities in Parkinson's disease: evidence for a neurotoxic cause? by Newbold, S.G, Rostami-Hodjeqan, A, Lennard, M.S, Grunewald, R.A

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Determination of midazolam and 1′-hydroxymidazolam by liquid chromatography–mass spectrometry in plasma of patients undergoing methadone maintenance treatment by Shiran, M.R, Gregory, A, Rostami-Hodjegan, A, Tucker, G.T, Lennard, M.S

“…A rapid, sensitive and selective LC–MS method was developed for the simultaneous determination of midazolam (MDZ) and 1′-hydroxymidazolam (1′-OHMDZ) in plasma…”
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The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6) by Tucker, G T, Lennard, M S, Ellis, S W, Woods, H F, Cho, A K, Lin, L Y, Hiratsuka, A, Schmitz, D A, Chu, T Y

“…The metabolism of methylenedioxymethamphetamine (MDMA, "ecstasy") was examined in a microsomal preparation of the yeast Saccharomyces cerevisiae expressing…”
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PRN prescribing in psychiatric inpatients - potential for pharmacokinetic drug interactions by Davies, S., Lennard, M. S., Ghahramani, P., Pratt, P., Robertson, A., Potokar, J.

“…Abstract only…”
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The effect of selective serotonin re‐uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes by Crewe, H.K., Lennard, M.S., Tucker, G.T., Woods, F.R., Haddock, R.E.

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Enantiomer specific pharmacokinetics by Tucker, G T, Lennard, M S

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The polymorphic oxidation of beta-adrenoceptor antagonists by Lennard, M S

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Polypeptide and protein drugs : Edited by R.C. Hider and D. Barlowi; Ellis Horwood; New York, 1991; 281 pages; £45.00 by Lennard, M.S.

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The Polymorphic Oxidation of ??-Adrenoceptor Antagonists: Clinical Pharmacokinetic Considerations by Lennard, M.S., Tucker, G.T., Woods, H.F.

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Polypeptide and protein drugs by Lennard, M.S.

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Lack of relationships between the debrisoquine (CYP2D6) and mephenytion (CYP2C19) oxidation polymorphisms and susceptibility to breast cancer by Jennings, M., Sweetland, H., Smith, C.A.D, Wolf, C.R., Lennard, M.S., Tucker, G.T., Woods, H.F., Rogers, K.

“…The cytochrome P450 superfamily of enzymes is important in the metabolism of many drugs and in the activation of chemical carcinogens. The activities of two…”
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The metabolism of tamoxifen by human liver microsomes is not mediated by cytochrome P450IID6 by Blankson, E A, Ellis, S W, Lennard, M S, Tucker, G T, Rogers, K

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