Search Results - "Lenhard, J. M."

Direct renin inhibition improves parasympathetic function in diabetes by Maser, R. E., Lenhard, M. J., Kolm, P., Edwards, D. G.

“…Aim The renin‐angiotensin‐aldosterone system (RAAS) and autonomic nervous system regulate the cardiovascular system. Blockade of the RAAS may slow the…”
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The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction by LENHARD, J. M, LANCASTER, M. E, PAULIK, M. A, WEIEL, J. E, BINZ, J. G, SUNDSETH, S. S, GASKILL, B. A, LIGHTFOOT, R. M, BROWN, H. R

“…Although retinoid X receptor (RXR) and peroxisome proliferator activated receptor-gamma (PPARgamma) agonists have antidiabetic effects in hyperinsulinaemic…”
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Evidence for ADP-ribosylation factor (ARF) as a regulator of in vitro endosome-endosome fusion by LENHARD, J. M, KAHN, R. A, STAHL, P. D

“…We have used an in vitro endosome fusion assay, recombinant ARF, synthetic peptides, and guanosine 5'-3-O-(thio)triphosphate (GTP gamma S) to study the role of…”
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Dietary fat alters HIV protease inhibitor-induced metabolic changes in mice by Lenhard, J M, Croom, D K, Weiel, J E, Spaltenstein, A, Reynolds, D J, Furfine, E S

“…Human immunodeficiency virus (HIV) protease inhibitors (PI) may alter lipid metabolism in patients with acquired immunodeficiency syndrome (AIDS). However, the…”
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Effects of troglitazone and metformin on glucose and lipid metabolism: Alterations of two distinct molecular pathways by Lenhard, James M, Kliewer, Steven A, Paulik, Mark A, Plunket, Kelli D, Lehmann, Jurgen M, Weiel, James E

“…Troglitazone and metformin are antidiabetic agents that belong to the thiazolidinedione and biguanide classes of drugs, respectively. To evaluate how these…”
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PPAR gamma/RXR as a molecular target for diabetes by Lenhard, J M

“…Type 2 diabetes is associated with insulin resistance in peripheral tissues, such as muscle and fat. Novel therapies that improve insulin action include…”
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Development of infrared imaging to measure thermogenesis in cell culture : Thermogenic effects of uncoupling protein-2, troglitazone, and β-adrenoceptor agonists by PAULIK, M. A, BUCKHOLZ, R. G, LANCASTER, M. E, DALLAS, W. S, HULL-RYDE, E. A, WEIEL, J. E, LENHARD, J. M

“…Although the effects of thermogenic agents in cell culture can be measured by direct microcalorimetry, only a few samples can be analyzed over several hours…”
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Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells by Verghese, M W, McConnell, R T, Lenhard, J M, Hamacher, L, Jin, S L

“…Many functions of the immune and inflammatory responses are inhibited by agents that increase intracellular levels of cAMP. Recent investigations have revealed…”
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Continuous subcutaneous insulin infusion: a comprehensive review of insulin pump therapy by Lenhard, M J, Reeves, G D

“…A tremendous amount of data suggest that near-normal glycemic control prevents or delays complications of diabetes, which has led to a dramatic increase in…”
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Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs by Lehmann, Jürgen M., Lenhard, James M., Oliver, Beverly B., Ringold, Gordon M., Kliewer, Steven A.

“…Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) and cyclooxygenase inhibitor that is frequently used as a research tool to study the process of…”
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Bone mineral loss in HIV-positive patients receiving antiretroviral therapy by WEIEL, James E, LENHARD, James M

“…Tebas and colleagues employed dual-energy X-ray absorptiometry to measure bone mineral density (BMD) in a cross-sectional analysis of 112 male subjects,…”
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Select HIV Protease Inhibitors Alter Bone and Fat Metabolism ex Vivo by Jain, Renu G., Lenhard, James M.

“…Human immunodeficiency virus (HIV) therapies have been associated with alterations in fat metabolism and bone mineral density. This study examined the effects…”
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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma by Kliewer, S.A. (Glaxo Wellcome Research and Development, Research Triangle Park, NC.), Sundseth, S.S, Jones, S.A, Brown, P.J, Wisely, G.B, Koble, C.S, Devchand, P, Walhi, W, Willson, T.M, Lenhard, J.M

“…Peroxisome proliferator-activated receptors (PPARs) alpha and gamma are key regulators of lipid homeostasis and are activated by a structurally diverse group…”
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Characterization of endosome-endosome fusion in a cell-free system using Dictyostelium discoideum by Lenhard, J M, Mayorga, L, Stahl, P D

“…An in vitro endosome fusion assay using Dictyostelium discoideum is described. The method requires endocytosis of anti-dinitrophenol (DNP) IgG or…”
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A Peroxisome Proliferator-Activated Receptor γ Ligand Inhibits Adipocyte Differentiation by Oberfield, Jennifer L., Collins, Jon L., Holmes, Christopher P., Goreham, Donna M., Cooper, Joel P., Cobb, Jeffery E., Lenhard, James M., Hull-Ryde, Emily A., Mohr, Christopher P., Blanchard, Steven G., Parks, Derek J., Moore, Linda B., Lehmann, Jürgen M., Plunket, Kelli, Miller, Ann B., Milburn, Michael V., Kliewer, Steven A., Willson, Timothy M.

“…The peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that regulate glucose and lipid homeostasis. The PPARγ subtype plays a…”
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Vibratory Thresholds Correlation With Systolic Blood Pressure in Diabetic Women by Maser, Raelene E, Lenhard, M.James, DeCherney, G.Stephen

“…Previous studies have suggested a potential association of elevated blood pressure (BP) and the development of diabetic neuropathy for individuals with…”
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HIV Protease Inhibitors Stimulate Hepatic Triglyceride Synthesis by Lenhard, James M, Croom, Dallas K, Weiel, James E, Winegar, Deborah A

“…Abstract—Hyperlipidemia may complicate the use of HIV protease inhibitors (PIs) in AIDS therapy. To determine the cause of hyperlipidemia, the effect of PIs on…”
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Metabolic complications associated with antiretroviral therapy by Jain, Renu G, Furfine, Eric S, Pedneault, Louise, White, Alex J, Lenhard, James M

“…Mortality rates in the HIV-infected patient population have decreased with the advent of highly active antiretroviral therapy (HAART) for the treatment of…”
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Muscle Rad expression and human metabolism: potential role of the novel Ras-related GTPase in energy expenditure and body composition by Garvey, W. T., Maianu, L., Kennedy, A., Wallace, P., Ganaway, E., Hamacher, L. L., Yarnall, D. P., Lenhard, J. M., Burns, D. K.

“…Muscle Rad expression and human metabolism: potential role of the novel Ras-related GTPase in energy expenditure and body composition. W T Garvey , L Maianu ,…”
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A comparison between alternative and trade name glucose test strips by LENHARD, M. J, DECHERNEY, G. S, MASER, R. E, PATTEN, B. C, KUBIK, J

“…A comparison between alternative and trade name glucose test strips. M J Lenhard , G S DeCherney , R E Maser , B C Patten and J Kubik Diabetes and Metabolic…”
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