Search Results - "Lengner, C."

A FoxL1-CreERT-2A-tdTomato Mouse Labels Subepithelial Telocytes by Kolev, H.M., Tian, Y., Kim, M.S., Leu, N.A., Adams-Tzivelekidis, S., Lengner, C.J., Li, N., Kaestner, K.H.

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P-109 Broaden the therapeutic opportunities for colorectal cancer: ALK inhibition benefits consensus molecular subtype 1 patients by Mazzeschi, M., Sgarzi, M., Romaniello, D., Ambrosi, F., Morselli, A., Girone, C., Pagano, F., Rihawi, K., D'Uva, G., Ferracin, M., Fiorentino, M., Ardizzoni, A., Győrffy, B., Palmer, R., Li, N., Lengner, C., Mossé, Y., Lauriola, M.

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Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency by Hanna, Jacob, Markoulaki, Styliani, Schorderet, Patrick, Carey, Bryce W., Beard, Caroline, Wernig, Marius, Creyghton, Menno P., Steine, Eveline J., Cassady, John P., Foreman, Ruth, Lengner, Christopher J., Dausman, Jessica A., Jaenisch, Rudolf

“…Pluripotent cells can be derived from fibroblasts by ectopic expression of defined transcription factors. A fundamental unresolved question is whether…”
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Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors by Lian, Jane B, Javed, Amjad, Zaidi, S Kaleem, Lengner, Christopher, Montecino, Martin, van Wijnen, Andre J, Stein, Janet L, Stein, Gary S

“…Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone in the adult involve an exquisite interplay of developmental cues,…”
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An Alternative Splice Form of Mdm2 Induces p53-independent Cell Growth and Tumorigenesis by Steinman, Heather A., Burstein, Ezra, Lengner, Christopher, Gosselin, Joseph, Pihan, German, Duckett, Colin S., Jones, Stephen N.

“…The Mdm2 gene is amplified in approximately one-third of human sarcomas and overexpressed in a variety of other human cancers. Mdm2 functions as an…”
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Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression by Gaur, Tripti, Lengner, Christopher J., Hovhannisyan, Hayk, Bhat, Ramesh A., Bodine, Peter V.N., Komm, Barry S., Javed, Amjad, van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.

“…Both activating and null mutations of proteins required for canonical WNT signaling have revealed the importance of this pathway for normal skeletal…”
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Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling by Lengner, Christopher J, Steinman, Heather A, Gagnon, James, Smith, Thomas W, Henderson, Janet E, Kream, Barbara E, Stein, Gary S, Lian, Jane B, Jones, Stephen N

“…Mdm2 is required to negatively regulate p53 activity at the peri-implantation stage of early mouse development. However, the absolute requirement for Mdm2…”
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Nkx3.2-mediated Repression of Runx2 Promotes Chondrogenic Differentiation by Lengner, Christopher J., Hassan, Mohammad Q., Serra, Ryan W., Lepper, Christoph, van Wijnen, Andre J., Stein, Janet L., Lian, Jane B., Stein, Gary S.

“…Runx2, a transcription factor known to be essential for osteoblast maturation and skeletogenesis, is also expressed in pre-cartilaginous mesenchymal…”
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Primary mouse embryonic fibroblasts: A model of mesenchymal cartilage formation by Lengner, Christopher J., Lepper, Christoph, van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.

“…Cartilage formation is an intricate process that requires temporal and spatial organization of regulatory factors in order for a mesenchymal progenitor cell to…”
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Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene by Odgren, P R, Kim, N, van Wesenbeeck, L, MacKay, C, Mason-Savas, A, Safadi, F F, Popoff, S N, Lengner, C, van-Hul, W, Choi, Y, Marks, Jr, S C

“…The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required for normal osteoclast differentiation. Although the…”
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Activation of the bone-related Runx2/ Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton by Lengner, Christopher J., Drissi, Hicham, Choi, Je-Yong, van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.

“…The Runx2/Cbfa1 transcription factor regulates a program of gene expression necessary for skeletal development. To understand signals mediating skeletal…”
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