Search Results - "Lenger, Steve"

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  1. 1
    Systematic analysis of CRISPR–Cas9 mismatch tolerance reveals low levels of off-target activity

    Systematic analysis of CRISPR–Cas9 mismatch tolerance reveals low levels of off-target activity by Anderson, Emily M., Haupt, Amanda, Schiel, John A., Chou, Eldon, Machado, Hidevaldo B., Strezoska, Žaklina, Lenger, Steve, McClelland, Shawn, Birmingham, Amanda, Vermeulen, Annaleen, Smith, Anja van Brabant

    Published in Journal of biotechnology (10-10-2015)
    “…•CRISPR–Cas9 with synthetic crRNA: tracrRNA is an efficient system for gene editing.•We tested 100s of mismatched-to-target crRNAs in a high-throughput…”
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    Next Generation NKG2D-based CAR T-cells (CYAD-02): Co-expression of a Single shRNA Targeting MICA and MICB Improves Cell Persistence and Anti-Tumor Efficacy in vivo

    Next Generation NKG2D-based CAR T-cells (CYAD-02): Co-expression of a Single shRNA Targeting MICA and MICB Improves Cell Persistence and Anti-Tumor Efficacy in vivo by Fontaine, Martina, Demoulin, Benjamin, Bornschein, Simon, Raitano, Susanna, Lenger, Steve, Machado, Hidevaldo, Moore, Jonathan D, Sotiropoulou, Panagiota A., Gilham, David E

    Published in Blood (13-11-2019)
    “…Background The Natural Killer Group 2D (NKG2D) receptor is a NK cell activating receptor that binds to eight different ligands (NKG2DL) commonly over-expressed…”
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