Search Results - "Leng, Tiandong"

Treatment for ischemic stroke: From thrombolysis to thrombectomy and remaining challenges by Leng, Tiandong, Xiong, Zhi-Gang

“…Stroke is a leading cause of death and long-term disabilities. Despite decades of extensive efforts in search of brain injury mechanisms and therapeutic…”
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Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke? by Leng, Tiandong, Shi, Yejie, Xiong, Zhi-Gang, Sun, Dandan

“…Ischemic brain injury results from complicated cellular mechanisms. The present therapy for acute ischemic stroke is limited to thrombolysis with the…”
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Silencing TRPM7 in mouse cortical astrocytes impairs cell proliferation and migration via ERK and JNK signaling pathways by Zeng, Zhao, Leng, Tiandong, Feng, Xuechao, Sun, Huawei, Inoue, Koichi, Zhu, Li, Xiong, Zhi-Gang

“…Transient receptor potential melastatin 7 (TRPM7), a non-selective cation channel, is highly expressed expressed in the brain and plays a critical role in…”
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Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells by Shu, Minfeng, Zheng, Xiaoke, Wu, Sihan, Lu, Huimin, Leng, Tiandong, Zhu, Wenbo, Zhou, Yuehan, Ou, Yanqiu, Lin, Xi, Lin, Yuan, Xu, Dong, Zhou, Yuxi, Yan, Guangmei

“…Astrocytomas are the most common and aggressive brain tumors characterized by their highly invasive growth. Gain of chromosome 7 with a hot spot at 7q32…”
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Role of serum‐ and glucocorticoid‐inducible kinases in stroke by Inoue, Koichi, Leng, Tiandong, Yang, Tao, Zeng, Zhao, Ueki, Takatoshi, Xiong, Zhi‐Gang

“…Increased expression of serum‐ and glucocorticoid‐inducible kinase 1 (SGK1) can be induced by stress and growth factors in mammals, and plays an important role…”
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Serum- and glucocorticoid-inducible kinases in microglia by Inoue, Koichi, Sakuma, Eisuke, Morimoto, Hiroyuki, Asai, Hayato, Koide, Yoshinori, Leng, Tiandong, Wada, Ikuo, Xiong, Zhi-Gang, Ueki, Takatoshi

“…Microglia are derived from myelogenous cells and contribute to immunological and inflammatory responses in central nervous system. They play important roles…”
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Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell by Liu, Xincheng, Guo, Cui, Leng, Tiandong, Fan, Zhen, Mai, Jialuo, Chen, Jiehong, Xu, Jinhai, Li, Qianyi, Jiang, Bin, Sai, Ke, Yang, Wenzhuo, Gu, Jiayu, Wang, Jingyi, Sun, Shuxin, Chen, Zhijie, Zhong, Yingqian, Liang, Xuanming, Chen, Chaoxin, Cai, Jing, Lin, Yuan, Liang, Jiankai, Hu, Jun, Yan, Guangmei, Zhu, Wenbo, Yin, Wei

“…Differentiation therapy using small molecules is a promising strategy for improving the prognosis of glioblastoma (GBM). Histone acetylation plays an important…”
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TRPM7 regulates vascular endothelial cell adhesion and tube formation by Zeng, Zhao, Inoue, Koichi, Sun, Huawei, Leng, Tiandong, Feng, Xuechao, Zhu, Li, Xiong, Zhi-Gang

“…Transient receptor potential melastatin 7 (TRPM7) is a nonselective cation channel with an α-kinase domain in its COOH terminal, known to play a role in…”
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Role of TRPM7 channels in hyperglycemia-mediated injury of vascular endothelial cells by Sun, Huawei, Leng, Tiandong, Zeng, Zhao, Gao, Xiuren, Inoue, Koichi, Xiong, Zhi-Gang

“…This study investigated the change of transient receptor potential melastatin 7 (TRPM7) expression by high glucose and its role in hyperglycemia induced injury…”
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Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors by Xie, Mian, Leng, Tiandong, Maysami, Samaneh, Pearson, Andrea, Simon, Roger, Xiong, Zhi-Gang, Meller, Robert

“…In this study, we characterize biophysical changes in NMDA receptor function in response to brief non-injurious ischemic stress (ischemic preconditioning)…”
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Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics by Ou, Yanqiu, Ph.D., M.D, Zheng, Xiaoke, Ph.D., M.D, Gao, Yixing, M.D, Shu, Minfeng, Ph.D., M.D, Leng, Tiandong, Ph.D., M.D, Li, Yan, Ph.D., M.D, Yin, Wei, Ph.D, Zhu, Wenbo, Ph.D, Huang, Yijun, Ph.D., M.D, Zhou, Yuxi, Ph.D, Tang, Jianjun, Ph.D, Qiu, Pengxin, M.B.B.S, Yan, Guangmei, Ph.D., M.D, Hu, Jun, Ph.D, Ruan, Huaizhen, Ph.D., M.D, Hu, Haiyan, Ph.D., M.D

“…Abstract Objective With the notorious reputation of the vicious invasion, the bladder cancer is the most common malignant tumor of the urinary system…”
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Simultaneous Determination of Seven Neuroactive Steroids Associated with Depression in Rat Plasma and Brain by High Performance Liquid Chromatography–Tandem Mass Spectrometry by WANG, Youqiong, TANG, Lipeng, YIN, Wei, CHEN, Jiesi, LENG, Tiandong, ZHENG, Xiaoke, ZHU, Wenbo, ZHANG, Haipeng, QIU, Pengxin, YANG, Xiaoxiao, YAN, Guangmei, HU, Haiyan

“…Sensitive and specific biomarkers are required for the diagnosis and treatment of depression because the existing diagnostic criteria are subjective and could…”
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Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons by YAN, MIN, ZHU, WENBO, ZHENG, XIAOKE, LI, YUAN, TANG, LIPENG, LU, BINGZHENG, CHEN, WENLI, QIU, PENGXIN, LENG, TIANDONG, LIN, SUIZHEN, YAN, GUANGMEI, YIN, WEI

“…Glutamate is the principal neurotransmitter in the central nervous system. Glutamate-mediated excitotoxicity is the predominant cause of cerebral damage…”
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Triptolide-induced cell cycle arrest and apoptosis in human renal cell carcinoma cells by Li, Jingjie, Zhu, Wenbo, Leng, Tiandong, Shu, Minfeng, Huang, Yijun, Xu, Dong, Qiu, Pengxin, Su, Xingwen, Yan, Guangmei

“…Renal cell carcinoma (RCC) is the most frequent type of renal-originated malignancy. Although nephrectomy is successfully used to save the lives of patients…”
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Synthesis and anti-glioma activity of 25(R)-spirostan-3β,5α,6β,19-tetrol by Leng, TianDong, Zhang, JingXia, Xie, Jun, Zhou, ShuJia, Huang, YiJun, Zhou, YueHan, Zhu, WenBo, Yan, GuangMei

“…Malignant gliomas are common and aggressive brain tumours in adults. The rapid proliferation and diffuse brain migration are the main obstacles to successful…”
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Role of Cholesterol Metabolic Enzyme CYP46A1 and Its Metabolite 24S-Hydroxycholesterol in Ischemic Stroke by Sun, Huawei, Yang, Tao, Simon, Roger P, Xiong, Zhi-Gang, Leng, Tiandong

“…For several decades, it has been recognized that overactivation of the glutamate-gated N-methyl-D-aspartate receptors (NMDARs) and subsequent Ca toxicity play…”
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Cholestane-3β,5α,6β-Triol Inhibits Acid-Sensing Ion Channels and Reduces Acidosis-Mediated Ischemic Brain Injury by Sun, Huawei, Yang, Tao, Simon, Roger, Xiong, Zhi-Gang, Leng, Tiandong

“…Activation of the acid-sensing ion channels (ASICs) by tissue acidosis, a common feature of brain ischemia, contributes to ischemic brain injury, while…”
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TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways by Liu, Mingli, Inoue, Koichi, Leng, Tiandong, Guo, Shanchun, Xiong, Zhi-gang

“…Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults with median survival time of 14.6months. A small fraction of…”
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β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation by Zhou, Renpeng, Leng, Tiandong, Yang, Tao, Chen, Feihu, Hu, Wei, Xiong, Zhi-Gang

“…BACKGROUND AND PURPOSE—Sex differences in the incidence and outcome of stroke have been well documented. The severity of stroke in women is, in general,…”
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Acid-sensing ion channel 1 (ASIC1) mediates weak acid-induced migration of human malignant glioma cells by Sheng, Yulan, Wu, Baoming, Leng, Tiandong, Zhu, Li, Xiong, Zhigang

“…Glioblastoma is the most aggressive and lethal tumor in the central nervous system in adult and has poor prognosis due to strong proliferation and aggressive…”
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