Search Results - "Lendon, C L"

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 by Hutton, Mike, Heutink, Peter, Lendon, Corinne L, Rizzu, Patrizia, Baker, Matt, Froelich, Susanne, Houlden, Henry, Pickering-Brown, Stuart, Chakraverty, Sumi, Isaacs, Adrian, Grover, Andrew, Hackett, Jennifer, Adamson, Jennifer, Lincoln, Sarah, Dickson, Dennis, Davies, Peter, Petersen, Ronald C, Stevens, Martijn, de Graaff, Esther, Wauters, Erwin, van Baren, Jeltje, Hillebrand, Marcel, Joosse, Marijke, Kwon, Jennifer M, Nowotny, Petra, Che, Lien Kuei, Norton, Joanne, Morris, John C, Reed, Lee A, Trojanowski, John, Basun, Hans, Lannfelt, Lars, Neystat, Michael, Fahn, Stanley, Dark, Francis, Tannenberg, Tony, Dodd, Peter R, Hayward, Nick, Kwok, John B. J, Schofield, Peter R, Andreadis, Athena, Snowden, Julie, Craufurd, David, Neary, David, Owen, Frank, Oostra, Ben A, Hardy, John, Goate, Alison, van Swieten, John, Mann, David, Lynch, Timothy

“…Thirteen families have been described with an autosomal dominantly inherited dementia named frontotemporal dementia and parkinsonism linked to chromosome 17…”
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The effect of the apolipoprotein E gene polymorphisms and haplotypes on behavioural and psychological symptoms in probable Alzheimer’s disease by Pritchard, A L, Harris, J, Pritchard, C W, Coates, J, Haque, S, Holder, R, Bentham, P, Lendon, C L

“…Background: Patients with Alzheimer’s disease and dementia commonly suffer from behavioural and psychological symptoms of dementia (BPSD). A genetic component…”
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Contribution of APOE promoter polymorphisms to Alzheimer's disease risk by LAMBERT, J.-C, ARARIA-GOUMIDI, L, FRIGARD, B, PETERSEN, R. C, CUMMING, A. M, PASQUIER, F, SASTRE, I, TIENARI, P. J, FRANK, A, SULKAVA, R, MORRIS, J. C, CLAIR, D. St, MYLLYKANGAS, L, MANN, D. M, WAVRANT-DEVRIEZE, F, EZQUERRA-TRABALON, M, AMOUYEL, P, HARDY, J, HALTIA, M, VALDIVIESO, F, GOATE, A. M, PEREZ-TUR, J, LENDON, C. L, ELLIS, C, CHARTIER-HARLIN, M.-C, WANG, J. C, BULLIDO, M. J, HARRIS, J. M, ARTIGA, M. J, HERNANDEZ, D, KWON, J. M

“…To determine whether the effects of APOE promoter polymorphisms on AD are independent of the APOE-epsilon4 allele. Recently, the -491 A-->T and -219 G-->T…”
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Genetic variation of the APOE promoter and outcome after head injury by LENDON, C. L, HARRIS, J. M, PRITCHARD, A. L, NICOLL, J. A. R, TEASDALE, G. M, MURRAY, G

“…The APOE-epsilon4 allele is associated with risk for Alzheimer's disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in…”
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Risk for Alzheimer's Disease Correlates with Transcriptional Activity of the APOE Gene by Artiga, M. J., Bullido, M. J., Frank, A., Sastre, I., Recuero, M., García, M. A., Lendon, C. L., Han, S. W., Morris, J. C., Vázquez, J., Goate, A., Valdivieso, F.

“…While the ε4 allele of apolipoprotein E (APOE, gene; ApoE, protein) is widely accepted as a major genetic risk factor for the late onset form of Alzheimer's…”
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Genetic associations between cathepsin D exon 2 C→T polymorphism and Alzheimer’s disease, and pathological correlations with genotype by Davidson, Y, Gibbons, L, Pritchard, A, Hardicre, J, Wren, J, Tian, J, Shi, J, Stopford, C, Julien, C, Thompson, J, Payton, A, Thaker, U, Hayes, A J, Iwatsubo, T, Pickering-Brown, S M, Pendleton, N, Horan, M A, Burns, A, Purandare, N, Lendon, C L, Neary, D, Snowden, J S, Mann, D M A

“…Genetic variations represent major risk factors for Alzheimer’s disease (AD). While familial early onset AD is associated with mutations in the amyloid…”
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Association between apolipoprotein E e4 allele and arteriosclerosis, cerebral amyloid angiopathy, and cerebral white matter damage in Alzheimer’s disease by Tian, J, Shi, J, Bailey, K, Lendon, C L, Pickering-Brown, S M, Mann, D M A

“…Objective: To investigate the association between white matter damage, as evidenced by myelin loss (ML), the extent of cerebral amyloid angiopathy (CAA), or…”
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A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer’s disease by Hayes, A, Green, E K, Pritchard, A, Harris, J M, Zhang, Y, Lambert, J C, Chartier-Harlin, M C, Pickering-Brown, S M, Lendon, C L, Mann, D M A

“…Objective: To investigate the impact of possession of the −889 C/T polymorphism of the interleukin 1A gene (IL-1A) and the −511 C/T polymorphism of the…”
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Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD? by GREEN, E. K, HARRIS, J. M, LEMMON, H, LAMBERT, J. C, CHARTIER-HARLIN, M. C, CLAIR, D. St, MANN, D. M. A, IWATSUBO, T, LENDON, C. L

“…Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and…”
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A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease by Tian, J, Shi, J, Bailey, K, Harris, J.M, Pritchard, A, Lambert, J.-C, Chartier-Harlin, M.-C, Pickering-Brown, S.M, Lendon, C.L, Mann, D.M.A

“…The impact of the insertion (I)/deletion (D) (I/D) polymorphism in the angiotensin 1-converting enzyme (ACE) gene on the extent of white matter myelin loss…”
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The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease by Lendon, C.L, Thaker, U, Harris, J.M, McDonagh, A.M, Lambert, J.-C, Chartier-Harlin, M.-C, Iwatsubo, T, Pickering-Brown, S.M, Mann, D.M.A

“…An insertion (I)/deletion (D) polymorphism in the angiotensin 1-converting enzyme (ACE) gene has, in some studies, been associated with increased risk for…”
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Hereditary dysphasic disinhibition dementia : A frontotemporal dementia linked to 17q21-22 by LENDON, C. L, LYNCH, T, WILHELMSEN, K. C, HANSEN, L, MORRIS, J. C, GOATE, A. M, NORTON, J, MCKEEL, D. W, BUSFIELD, F, CRADDOCK, N, CHAKRAVERTY, S, GOPALAKRISHNAN, G, SHEARS, S. D, GRIMMETT, W

“…The clinical and pathologic features of hereditary dysphasic disinhibition dementia (HDDD) are described to determine whether it is a variant of known…”
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Atherosclerotic plaque caps are locally weakened when macrophages density is increased by Lendon, C L, Davies, M J, Born, G V, Richardson, P D

“…The density of macrophages, identified by the antibody EBMII, in human aortic plaque caps was counted. A contiguous strip of cap tissue was tested…”
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Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population by Lendon, Corinne L, J. Talbot, Christopher, Craddock, Nick J, Woo Han, Sang, Wragg, Michelle, Morris, John C, Goate, Alison M

“…The ϵ4 allele of the apolipoprotein E gene (ApoE) is associated with an increased risk for sporadic and some familial forms of Alzheimer's disease (AD) but the…”
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Human leucocyte antigen-A2 increases risk of Alzheimer's disease but does not affect age of onset in a Scottish population by Harris, J.M, Cumming, A.M, Craddock, N, St Clair, D, Lendon, C.L

“…The use of non-steroidal anti-inflammatory drugs has been associated with a reduced incidence of Alzheimer's disease (AD), suggesting that attenuation of the…”
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The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease by LAMBERT, Jean-Charles, GOUMIDI, Louisa, ST CLAIR, David, MANN, David M. A, HARDY, John, LENDON, Corinne L, AMOUYEL, Philippe, CHARTIER-HARLIN, Marie-Christine, VRIEZE, Fabienne Wavrant-De, FRIGARD, Bernard, HARRIS, Judith M, CUMMINGS, Alistair, COATES, John, PASQUIER, Florence, COTTEL, Dominique, GAILLAC, Marianne

“…Although the varepsilon4 allele of the apolipoprotein E gene appears as an important biological marker for Alzheimer's disease (AD) susceptibility, other…”
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A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain by Green, E.K, Thaker, U, McDonagh, A.M, Iwatsubo, T, Lambert, J.-C, Chartier-Harlin, M.-C, Harris, J.M, Pickering-Brown, S.M, Lendon, C.L, Mann, D.M.A

“…There are numerous polymorphisms within the tau gene but these are in complete linkage disequilibrium and exist as two common extended haplotypes H1 and H2. We…”
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No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant by Wragg, Michelle A., Talbot, Christopher J., Morris, John C., Lendon, Corinne L., Goate, Alison M.

“…We have screened a large sample of patients with sporadic late-onset dementia of the Alzheimer type (DAT) and age-matched controls for a mitochondrial tRNA Gln…”
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The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology by Lemere, C A, Lopera, F, Kosik, K S, Lendon, C L, Ossa, J, Saido, T C, Yamaguchi, H, Ruiz, A, Martinez, A, Madrigal, L, Hincapie, L, Arango, J C, Anthony, D C, Koo, E H, Goate, A M, Selkoe, D J

“…Missense mutations in the presenilin 1 (PS1) gene cause the most common form of dominant early-onset familial Alzheimer's disease (FAD) and are associated with…”
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17β-oestradiol attenuates dexamethasone-induced lethal and sublethal neuronal damage in the striatum and hippocampus by Haynes, L.E, Lendon, C.L, Barber, D.J, Mitchell, I.J

“…Abnormal corticosteroid release is extensively associated with mood disorders. This association may result from the toxic actions of endogenous corticosteroids…”
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