Search Results - "Lenart, Nikolett"

Inflammasomes link vascular disease with neuroinflammation and brain disorders by Lénárt, Nikolett, Brough, David, Dénes, Ádám

“…The role of inflammation in neurological disorders is increasingly recognised. Inflammatory processes are associated with the aetiology and clinical…”
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Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke by Szalay, Gergely, Martinecz, Bernadett, Lénárt, Nikolett, Környei, Zsuzsanna, Orsolits, Barbara, Judák, Linda, Császár, Eszter, Fekete, Rebeka, West, Brian L., Katona, Gergely, Rózsa, Balázs, Dénes, Ádám

“…Microglia are the main immune cells of the brain and contribute to common brain diseases. However, it is unclear how microglia influence neuronal activity and…”
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Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms by Helyes, Zsuzsanna, Tékus, Valéria, Szentes, Nikolett, Pohóczky, Krisztina, Botz, Bálint, Kiss, Tamás, Kemény, Ágnes, Környei, Zsuzsanna, Tóth, Krisztina, Lénárt, Nikolett, Ábrahám, Hajnalka, Pinteaux, Emmanuel, Francis, Sheila, Sensi, Serena, Dénes, Ádám, Goebel, Andreas

“…Neuroimmune interactions may contribute to severe pain and regional inflammatory and autonomic signs in complex regional pain syndrome (CRPS), a posttraumatic…”
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Microglia–neuron–vascular interactions in ischemia by Lénárt, Nikolett, Cserép, Csaba, Császár, Eszter, Pósfai, Balázs, Dénes, Ádám

“…Cerebral ischemia is a devastating condition that results in impaired blood flow in the brain leading to acute brain injury. As the most common form of stroke,…”
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Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses by Winkler, Zsuzsanna, Kuti, Dániel, Polyák, Ágnes, Juhász, Balázs, Gulyás, Krisztina, Lénárt, Nikolett, Dénes, Ádám, Ferenczi, Szilamér, Kovács, Krisztina J.

“…Glucose is a major fuel for the central nervous system and hypoglycemia is a significant homeostatic stressor, which elicits counterregulatory reactions…”
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IL-1 Mediates Chronic Stress-Induced Hyperalgesia Accompanied by Microglia and Astroglia Morphological Changes in Pain-Related Brain Regions in Mice by Fülöp, Barbara, Hunyady, Ágnes, Bencze, Noémi, Kormos, Viktória, Szentes, Nikolett, Dénes, Ádám, Lénárt, Nikolett, Borbély, Éva, Helyes, Zsuzsanna

“…Chronic stress causes several pain conditions including fibromyalgia. Its pathophysiological mechanisms are unknown, and the therapy is unresolved. Since the…”
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Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer by Singel, Kelly L., Grzankowski, Kassondra S., Khan, A. N. M. Nazmul H., Grimm, Melissa J., D’Auria, Anthony C., Morrell, Kayla, Eng, Kevin H., Hylander, Bonnie, Mayor, Paul C., Emmons, Tiffany R., Lénárt, Nikolett, Fekete, Rebeka, Környei, Zsuzsanna, Muthukrishnan, Uma, Gilthorpe, Jonathan D., Urban, Constantin F., Itagaki, Kiyoshi, Hauser, Carl J., Leifer, Cynthia, Moysich, Kirsten B., Odunsi, Kunle, Dénes, Ádám, Segal, Brahm H.

“…Background Advanced cancer causes necrosis and releases damage-associated molecular patterns (DAMPs). Mitochondrial DAMPs activate neutrophils, including…”
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Overexpression of Hsp27 ameliorates symptoms of Alzheimer's disease in APP/PS1 mice by Tóth, Melinda Erzsébet, Szegedi, Viktor, Varga, Edina, Juhász, Gábor, Horváth, János, Borbély, Emőke, Csibrány, Balázs, Alföldi, Róbert, Lénárt, Nikolett, Penke, Botond, Sántha, Miklós

“…Hsp27 belongs to the small heat shock protein family, which are ATP-independent chaperones. The most important function of Hsp27 is based on its ability to…”
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Increased tau phosphorylation and impaired presynaptic function in hypertriglyceridemic ApoB-100 transgenic mice by Lénárt, Nikolett, Szegedi, Viktor, Juhász, Gábor, Kasztner, Aniko, Horváth, János, Bereczki, Erika, Tóth, Melinda E, Penke, Botond, Sántha, Miklós

“…ApoB-100 is the major protein component of cholesterol- and triglyceride-rich LDL and VLDL lipoproteins in the serum. Previously, we generated and partially…”
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Low dosage of rimonabant leads to anxiolytic-like behavior via inhibiting expression levels and G-protein activity of kappa opioid receptors in a cannabinoid receptor independent manner by Zádor, Ferenc, Lénárt, Nikolett, Csibrány, Balázs, Sántha, Miklós, Molnár, Máté, Tuka, Bernadett, Samavati, Reza, Klivényi, Péter, Vécsei, László, Marton, Annamária, Vizler, Csaba, Nagy, György M., Borsodi, Anna, Benyhe, Sándor, Páldy, Eszter

“…There is an increasing number of studies demonstrating the direct effect of the cannabinoid receptor 1 (CB1) antagonist/inverse agonist rimonabant on the…”
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Cultured cells of the blood-brain barrier from apolipoprotein B-100 transgenic mice: effects of oxidized low-density lipoprotein treatment by Lénárt, Nikolett, Walter, Fruzsina R, Bocsik, Alexandra, Sántha, Petra, Tóth, Melinda E, Harazin, András, Tóth, Andrea E, Vizler, Csaba, Török, Zsolt, Pilbat, Ana-Maria, Vígh, László, Puskás, László G, Sántha, Miklós, Deli, Mária A

“…The apolipoprotein B-100 (ApoB-100) transgenic mouse line is a model of human atherosclerosis. Latest findings suggest the importance of ApoB-100 in the…”
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Microglia monitor and protect neuronal function through specialized somatic purinergic junctions by Cserép, Csaba, Pósfai, Balázs, Lénárt, Nikolett, Fekete, Rebeka, László, Zsófia I, Lele, Zsolt, Orsolits, Barbara, Molnár, Gábor, Heindl, Steffanie, Schwarcz, Anett D, Ujvári, Katinka, Környei, Zsuzsanna, Tóth, Krisztina, Szabadits, Eszter, Sperlágh, Beáta, Baranyi, Mária, Csiba, László, Hortobágyi, Tibor, Maglóczky, Zsófia, Martinecz, Bernadett, Szabó, Gábor, Erdélyi, Ferenc, Szipőcs, Róbert, Tamkun, Michael M, Gesierich, Benno, Duering, Marco, Katona, István, Liesz, Arthur, Tamás, Gábor, Dénes, Ádám

“…Microglia are the main immune cells in the brain and have roles in brain homeostasis and neurological diseases. Mechanisms underlying microglia-neuron…”
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AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3 by Denes, Adam, Coutts, Graham, Lénárt, Nikolett, Cruickshank, Sheena M., Pelegrin, Pablo, Skinner, Joanne, Rothwell, Nancy, Allan, Stuart M., Brough, David

“…Significance Cerebral ischemia (CI; stroke, brain injury, vascular dementia, neonatal hypoxia, and many other conditions) affects people at all stages of life…”
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Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions by Császár, Eszter, Lénárt, Nikolett, Cserép, Csaba, Környei, Zsuzsanna, Fekete, Rebeka, Pósfai, Balázs, Balázsfi, Diána, Hangya, Balázs, Schwarcz, Anett D, Szabadits, Eszter, Szöllősi, Dávid, Szigeti, Krisztián, Máthé, Domokos, West, Brian L, Sviatkó, Katalin, Brás, Ana Rita, Mariani, Jean-Charles, Kliewer, Andrea, Lenkei, Zsolt, Hricisák, László, Benyó, Zoltán, Baranyi, Mária, Sperlágh, Beáta, Menyhárt, Ákos, Farkas, Eszter, Dénes, Ádám

“…Microglia, the main immunocompetent cells of the brain, regulate neuronal function, but their contribution to cerebral blood flow (CBF) regulation has remained…”
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Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms by Fekete, Rebeka, Cserép, Csaba, Lénárt, Nikolett, Tóth, Krisztina, Orsolits, Barbara, Martinecz, Bernadett, Méhes, Előd, Szabó, Bálint, Németh, Valéria, Gönci, Balázs, Sperlágh, Beáta, Boldogkői, Zsolt, Kittel, Ágnes, Baranyi, Mária, Ferenczi, Szilamér, Kovács, Krisztina, Szalay, Gergely, Rózsa, Balázs, Webb, Connor, Kovacs, Gabor G., Hortobágyi, Tibor, West, Brian L., Környei, Zsuzsanna, Dénes, Ádám

“…Neurotropic herpesviruses can establish lifelong infection in humans and contribute to severe diseases including encephalitis and neurodegeneration. However,…”
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The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner by Tóth, Krisztina, Lénárt, Nikolett, Berki, Péter, Fekete, Rebeka, Szabadits, Eszter, Pósfai, Balázs, Cserép, Csaba, Alatshan, Ahmad, Benkő, Szilvia, Kiss, Dániel, Hübner, Christian A, Gulyás, Attila, Kaila, Kai, Környei, Zsuzsanna, Dénes, Ádám

“…The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, the main inflammatory cells of…”
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Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices by Berki, Péter, Cserép, Csaba, Környei, Zsuzsanna, Pósfai, Balázs, Szabadits, Eszter, Domonkos, Andor, Kellermayer, Anna, Nyerges, Miklós, Wei, Xiaofei, Mody, Istvan, Kunihiko, Araki, Beck, Heinz, Kaikai, He, Ya, Wang, Lénárt, Nikolett, Wu, Zhaofa, Jing, Miao, Li, Yulong, Gulyás, Attila I., Dénes, Ádám

“…Acute brain slices represent a workhorse model for studying the central nervous system (CNS) from nanoscale events to complex circuits. While slice preparation…”
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Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons by Wong, Raymond, Lénárt, Nikolett, Hill, Laura, Toms, Lauren, Coutts, Graham, Martinecz, Bernadett, Császár, Eszter, Nyiri, Gábor, Papaemmanouil, Athina, Waisman, Ari, Müller, Werner, Schwaninger, Markus, Rothwell, Nancy, Francis, Sheila, Pinteaux, Emmanuel, Denés, Adam, Allan, Stuart M.

“…•Brain endothelial cells mediate detrimental actions of IL-1 in cerebral ischemia.•Neuronal cholinergic IL-1R1 also mediate detrimental actions of IL-1 in…”
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Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α by Orsini, Franca, Fumagalli, Stefano, Császár, Eszter, Tóth, Krisztina, De Blasio, Daiana, Zangari, Rosalia, Lénárt, Nikolett, Dénes, Ádám, De Simoni, Maria-Grazia

“…OBJECTIVE—Circulating complement factors are activated by tissue damage and contribute to acute brain injury. The deposition of MBL (mannose-binding lectin),…”
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Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain by Varga, Dániel P, Menyhárt, Ákos, Pósfai, Balázs, Császár, Eszter, Lénárt, Nikolett, Cserép, Csaba, Orsolits, Barbara, Martinecz, Bernadett, Szlepák, Tamás, Bari, Ferenc, Farkas, Eszter, Dénes, Ádám

“…Selective elimination of microglia from the brain was shown to dysregulate neuronal Ca2+ signaling and to reduce the incidence of spreading depolarization (SD)…”
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