Search Results - "Lenardo, Michael J."

Development of immune checkpoint therapy for cancer by Fritz, Jill M, Lenardo, Michael J

“…Since the early 20th century, immunologists have investigated mechanisms that protect vertebrates from damaging immune responses against self-antigens by…”
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XMEN disease: a new primary immunodeficiency affecting Mg2+ regulation of immunity against Epstein-Barr virus by Li, Feng-Yen, Chaigne-Delalande, Benjamin, Su, Helen, Uzel, Gulbu, Matthews, Helen, Lenardo, Michael J.

“…Epstein-Barr virus (EBV) is an oncogenic gammaherpesvirus that infects and persists in 95% of adults worldwide and has the potential to cause fatal disease,…”
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CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency by Lo, Bernice, Fritz, Jill M., Su, Helen C., Uzel, Gulbu, Jordan, Michael B., Lenardo, Michael J.

“…CTLA-4 is a critical inhibitory “checkpoint” molecule of immune activation. Several recent reports have described patients with immune dysregulation and…”
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Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis by Lu, Wei, Sun, Junhui, Yoon, Jeong Seon, Zhang, Yan, Zheng, Lixin, Murphy, Elizabeth, Mattson, Mark P, Lenardo, Michael J

“…Necroptosis as a molecular program, rather than simply incidental cell death, was established by elucidating the roles of receptor interacting protein (RIP)…”
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Termination of autophagy and reformation of lysosomes regulated by mTOR by Lenardo, Michael J, Yu, Li, McPhee, Christina K, Zheng, Lixin, Mardones, Gonzalo A, Rong, Yueguang, Peng, Junya, Mi, Na, Zhao, Ying, Liu, Zhihua, Wan, Fengyi, Hailey, Dale W, Oorschot, Viola, Klumperman, Judith, Baehrecke, Eric H

“…Autophagy is an evolutionarily conserved process by which cytoplasmic proteins and organelles are catabolized. During starvation, the protein TOR (target of…”
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CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model by Pandiyan, Pushpa, Conti, Heather R., Zheng, Lixin, Peterson, Alanna C., Mathern, Douglas R., Hernández-Santos, Nydiaris, Edgerton, Mira, Gaffen, Sarah L., Lenardo, Michael J.

“…Th17 cells and CD4+CD25+Foxp3+ regulatory T (Treg) cells are thought to promote and suppress inflammatory responses, respectively. Here we explore why under…”
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Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop by Oliveira, Joao B., Bleesing, Jack J., Dianzani, Umberto, Fleisher, Thomas A., Jaffe, Elaine S., Lenardo, Michael J., Rieux-Laucat, Frederic, Siegel, Richard M., Su, Helen C., Teachey, David T., Rao, V. Koneti

“…Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic dilemma. Autoimmune…”
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CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis by Ozen, Ahmet, Comrie, William A, Ardy, Rico C, Domínguez Conde, Cecilia, Dalgic, Buket, Beser, Ömer F, Morawski, Aaron R, Karakoc-Aydiner, Elif, Tutar, Engin, Baris, Safa, Ozcay, Figen, Serwas, Nina K, Zhang, Yu, Matthews, Helen F, Pittaluga, Stefania, Folio, Les R, Unlusoy Aksu, Aysel, McElwee, Joshua J, Krolo, Ana, Kiykim, Ayca, Baris, Zeren, Gulsan, Meltem, Ogulur, Ismail, Snapper, Scott B, Houwen, Roderick H.J, Leavis, Helen L, Ertem, Deniz, Kain, Renate, Sari, Sinan, Erkan, Tülay, Su, Helen C, Boztug, Kaan, Lenardo, Michael J

“…CD55 prevents convertase enzyme formation in the complement cascade, acting as a brake on complement activation. Inactivating mutations in CD55 result in…”
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Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation by Rong, Yueguang, McPhee, Christina, Deng, Shuangshen, Huang, Lei, Chen, Lilian, Liu, Mei, Tracy, Kirsten, Baehreck, Eric H, Yu, Li, Lenardo, Michael J

“…Autophagy is a conserved cellular process to degrade and recycle cytoplasmic components. During autophagy, lysosomes fuse with an autophagosome to form an…”
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30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology by Zhang, Qian, Lenardo, Michael J., Baltimore, David

“…NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in…”
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The selectivity of autophagy and its role in cell death and survival by Yu, Li, Strandberg, Lindsey, Lenardo, Michael J.

“…Autophagy is a cellular process whose primary function is to degrade long-lived proteins and recycle cellular components. Beside macroautophagy, there are…”
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The role of LRRK2 in inflammatory bowel disease by Liu, Zhihua, Lenardo, Michael J

“…LRRK2 was recently identified as a major susceptibility gene for Crohn＇s disease （CD） by genome-wide association studies （GWAS）. LRRK2 deficiency in mice…”
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Congenital B cell lymphocytosis explained by novel germline CARD11 mutations by Snow, Andrew L, Xiao, Wenming, Stinson, Jeffrey R, Lu, Wei, Chaigne-Delalande, Benjamin, Zheng, Lixin, Pittaluga, Stefania, Matthews, Helen F, Schmitz, Roland, Jhavar, Sameer, Kuchen, Stefan, Kardava, Lela, Wang, Wei, Lamborn, Ian T, Jing, Huie, Raffeld, Mark, Moir, Susan, Fleisher, Thomas A, Staudt, Louis M, Su, Helen C, Lenardo, Michael J

“…Nuclear factor-κB (NF-κB) controls genes involved in normal lymphocyte functions, but constitutive NF-κB activation is often associated with B cell malignancy…”
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Pozelimab for CHAPLE disease: results from in-trial interviews and clinical outcome assessments by Litcher-Kelly, Leighann, Ozen, Ahmet, Ollis, Sarah, Feldman, Hagit Baris, Yaworsky, Andrew, Medrano, Paolo, Chongsrisawa, Voranush, Brackin, Taylor, Perlee, Lorah, Walker, Marisa, Pradeep, Sharanya, Lenardo, Michael J, Harari, Olivier A, Jalbert, Jessica J

“…CD55 deficiency with hyper-activation of complement, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE) disease is ultra-rare (< 100 children or…”
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E2 interaction and dimerization in the crystal structure of TRAF6 by Yin, Qian, Lin, Su-Chang, Lamothe, Betty, Lu, Miao, Lo, Yu-Chih, Hura, Gregory, Zheng, Lixin, Rich, Rebecca L, Campos, Alejandro D, Myszka, David G, Lenardo, Michael J, Darnay, Bryant G, Wu, Hao

“…The signaling adaptor TRAF6 is a ubiquitin E3 ligase whose activity can lead to activation of NF-κB and MAPK pathways. New data based on the structure of TRAF6…”
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Genetic disorders of programmed cell death in the immune system by Bidère, Nicolas, Su, Helen C, Lenardo, Michael J

“…Human genetics offers new possibilities for understanding physiological regulatory mechanisms and disorders of the immune system. Genetic abnormalities of…”
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A guide to cancer immunotherapy: from T cell basic science to clinical practice by Waldman, Alex D., Fritz, Jill M., Lenardo, Michael J.

“…The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a central focus for engaging the immune system in the fight against…”
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power and the promise of restimulation-induced cell death in human immune diseases by Snow, Andrew L, Pandiyan, Pushpa, Zheng, Lixin, Krummey, Scott M, Lenardo, Michael J

“…Controlled expansion and contraction of lymphocytes both during and after an adaptive immune response are imperative to sustain a healthy immune system. Both…”
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ERO1 alpha deficiency impairs angiogenesis by increasing N-glycosylation of a proangiogenic VEGFA by Varone, Ersilia, Chernorudskiy, Alexander, Cherubini, Alessandro, Cattaneo, Angela, Bachi, Angela, Fumagalli, Stefano, Erol, Gizem, Gobbi, Marco, Lenardo, Michael J., Borgese, Nica, Zito, Ester

“…N-glycosylation and disulfide bond formation are two essential steps in protein folding that occur in the endoplasmic reticulum (ER) and reciprocally influence…”
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Molecular Determinants for Subcellular Localization of the Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame 3b Protein by FREUNDT, Eric C, LI YU, PARK, Elizabeth, LENARDO, Michael J, XU, Xiao-Ning

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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