Search Results - "Lenaeus, Michael J"

Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels by Catterall, William A, Lenaeus, Michael J, Gamal El-Din, Tamer M

“…Voltage-gated sodium and calcium channels are evolutionarily related transmembrane signaling proteins that initiate action potentials, neurotransmission,…”
Get full text

Structures of closed and open states of a voltage-gated sodium channel by Lenaeus, Michael J., El-Din, Tamer M. Gamal, Ing, Christopher, Ramanadane, Karthik, Pomès, Régis, Zheng, Ning, Catterall, William A.

“…Bacterial voltage-gated sodium channels (BacNavs) serve as models of their vertebrate counterparts. BacNavs contain conserved voltage-sensing and pore-forming…”
Get full text

Open-state structure and pore gating mechanism of the cardiac sodium channel by Jiang, Daohua, Banh, Richard, Gamal El-Din, Tamer M., Tonggu, Lige, Lenaeus, Michael J., Pomès, Régis, Zheng, Ning, Catterall, William A.

“…The heartbeat is initiated by voltage-gated sodium channel NaV1.5, which opens rapidly and triggers the cardiac action potential; however, the structural basis…”
Get full text

Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin by Tonggu, Lige, Wisedchaisri, Goragot, Gamal El-Din, Tamer M., Lenaeus, Michael J., Logan, Matthew M., Toma, Tatsuya, Du Bois, Justin, Zheng, Ning, Catterall, William A.

“…The poison dart toxin batrachotoxin is exceptional for its high potency and toxicity, and for its multifaceted modification of the function of voltage-gated…”
Get full text

Fenestropathy of Voltage-Gated Sodium Channels by Gamal El-Din, Tamer M, Lenaeus, Michael J

“…Voltage-gated sodium channels (Na ) are responsible for the initiation and propagation of action potentials in excitable cells. From pain to heartbeat, these…”
Get full text

Primary Care of the Patient with Asthma by Lenaeus, Michael J., MD, PhD, Hirschmann, Jan, MD

“…Obstructive lung disease includes asthma and chronic obstructive pulmonary disease (COPD). Because a previous issue of Medical Clinics of North America…”
Get full text

Structure of the Cardiac Sodium Channel by Jiang, Daohua, Shi, Hui, Tonggu, Lige, Gamal El-Din, Tamer M., Lenaeus, Michael J., Zhao, Yan, Yoshioka, Craig, Zheng, Ning, Catterall, William A.

“…Voltage-gated sodium channel Nav1.5 generates cardiac action potentials and initiates the heartbeat. Here, we report structures of NaV1.5 at 3.2–3.5 Å…”
Get full text

Fenestrations control resting-state block of a voltage-gated sodium channel by El-Din, Tamer M. Gamal, Lenaeus, Michael J., Zheng, Ning, Catterall, William A.

“…Potency of drug action is usually determined by binding to a specific receptor site on target proteins. In contrast to this conventional paradigm, we show here…”
Get full text

Structures of KcsA in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site by Lenaeus, Michael J, Burdette, Dylan, Wagner, Tobias, Focia, Pamela J, Gross, Adrian

“…Potassium channels allow for the passive movement of potassium ions across the cell membrane and are instrumental in controlling the membrane potential in all…”
Get full text

Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb by Gamal El-Din, Tamer M., Lenaeus, Michael J., Ramanadane, Karthik, Zheng, Ning, Catterall, William A.

“…Homotetrameric bacterial voltage-gated sodium channels share major biophysical features with their more complex eukaryotic counterparts, including a…”
Get full text

Structural Basis for Diltiazem Block of a Voltage-Gated Ca 2+ Channel by Tang, Lin, Gamal El-Din, Tamer M, Lenaeus, Michael J, Zheng, Ning, Catterall, William A

“…Diltiazem is a widely prescribed Ca antagonist drug for cardiac arrhythmia, hypertension, and angina pectoris. Using the ancestral Ca channel construct Ca Ab…”
Get more information

Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective by Gamal El-Din, Tamer M, Lenaeus, Michael J, Catterall, William A

“…Voltage-gated sodium channels initiate and propagate action potentials in excitable cells. They respond to membrane depolarization through opening, followed by…”
Get more information

Structural basis of TEA blockade in a model potassium channel by Gross, Adrian, Lenaeus, Michael J, Vamvouka, Magdalini, Focia, Pamela J

“…Potassium channels catalyze the selective transfer of potassium across the cell membrane and are essential for setting the resting potential in cells,…”
Get full text

Routine Chest Radiographs after Uncomplicated Thoracentesis by Lenaeus, Michael J., Shepherd, Amanda, White, Andrew A.

“…The “Things We Do for No Reason” series reviews practices which have become common parts of hospital care, but which may provide little value to our patients…”
Get full text

The Respiratory Substrate Rhodoquinol Induces Q-cycle Bypass Reactions in the Yeast Cytochrome bc1 Complex by Cape, Jonathan L., Strahan, Jeff R., Lenaeus, Michael J., Yuknis, Brook A., Le, Trieu T., Shepherd, Jennifer N., Bowman, Michael K., Kramer, David M.

“…The mitochondrial cytochrome bc1 complex catalyzes the transfer of electrons from ubiquinol to cyt c while generating a proton motive force for ATP synthesis…”
Get full text

Open-state structure and pore gating mechanism of the cardiac sodium channel by Jiang, Daohua, Banh, Richard L., El-Din, Tamer M. Gamal, Tonggu, Lige, Lenaeus, Michael J., Pomes, Regis, Zheng, Ning, Catterall, William A.

Get full text

Fenestrations Control the Resting State Block of a Voltage Gated Sodium Channel by Gamal El-Din, Tamer M., Lenaeus, Michael J., Zheng, Ning, Catterall, William A.

Get full text

Control of Slow, Use Dependent Inactivation of NaVAb by its C Terminal Tail by Gamal El-Din, Tamer M., Lenaeus, Michael J., Ramanadane, Karthik, Zheng, Ning, Catterall, William A.

Get full text

Control of Slow, Use Dependent Inactivation of Na V Ab by its C Terminal Tail by Gamal El-Din, Tamer M., Lenaeus, Michael J., Ramanadane, Karthik, Zheng, Ning, Catterall, William A.

Get full text

Asymmetrical Ligands in the Potassium Channel Cavity by Lenaeus, Michael J., Gross, Adrian

Get full text