Search Results - "Lemos, VS"
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1
Angiotensin-(1-7) Is an Endogenous Ligand for the G Protein-Coupled Receptor Mas
Published in Proceedings of the National Academy of Sciences - PNAS (08-07-2003)“…The renin-angiotensin system plays a critical role in blood pressure control and body fluid and electrolyte homeostasis. Besides angiotensin (Ang) II, other…”
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2
Decreased production of neuronal NOS‐derived hydrogen peroxide contributes to endothelial dysfunction in atherosclerosis
Published in British journal of pharmacology (01-11-2011)“…BACKGROUND AND PURPOSE Reduced NO availability has been described as a key mechanism responsible for endothelial dysfunction in atherosclerosis. We previously…”
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3
The new organic nitrate 2-nitrate-1,3-diocthanoxypropan (NDOP) induces nitric oxide production and vasorelaxation via activation of inward-rectifier potassium channels (KIR)
Published in Nitric oxide (01-11-2020)“…Cardiovascular diseases are coupled to decreased nitric oxide (NO) bioavailability, and there is a constant search for novel and better NO-donors. Here we…”
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4
Endothelium‐Independent Vasorelaxation Induced by Nitric Oxide Generation from the Novel Organic Nitrate NDOP Is Partially Mediated by Inward‐Rectifier Potassium Channels
Published in FASEB JOURNAL (01-04-2017)“…Abstract only Nitric oxide (NO) deficiency is crucially linked to the development and progression of cardiovascular diseases, including arterial hypertension…”
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Journal Article Conference Proceeding -
5
Phosphatidylinositol 3‐kinase‐δ up‐regulates L‐type Ca2+ currents and increases vascular contractility in a mouse model of type 1 diabetes
Published in British journal of pharmacology (01-12-2010)“…BACKGROUND AND PURPOSE Vasculopathies represent the main cause of morbidity and mortality in diabetes. Vascular malfunctioning in diabetes is associated with…”
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6
The novel organic mononitrate NDHP attenuates hypertension and endothelial dysfunction in hypertensive rats
Published in Redox biology (01-05-2018)“…Development and progression of cardiovascular diseases, including hypertension, are often associated with impaired nitric oxide synthase (NOS) function and…”
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7
The Endothelium-Dependent Vasodilator Effect of the Nonpeptide Ang(1-7) Mimic AVE 0991 Is Abolished in the Aorta of Mas-Knockout Mice
Published in Journal of cardiovascular pharmacology (01-09-2005)“…Recently, we demonstrated that the endothelium-dependent vasodilator effect of angiotensin(1-7) in the mouse aorta is abolished by genetic deletion of the G…”
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8
Carnivore mollusks as natural enemies of invasive land flatworms
Published in Annals of applied biology (01-09-2012)“…There are several records of the carnivorous behaviour of land flatworms, considered to be top‐predators in their micro‐habitats, by preying upon various…”
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9
Phosphatidylinositol 3-kinase-[delta] up-regulates L-type Ca2+ currents and increases vascular contractility in a mouse model of type 1 diabetes
Published in British journal of pharmacology (01-12-2010)“…BACKGROUND AND PURPOSE Vasculopathies represent the main cause of morbidity and mortality in diabetes. Vascular malfunctioning in diabetes is associated with…”
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Journal Article -
10
Phosphatidylinositol 3‐kinase‐δ up‐regulates L‐type Ca 2+ currents and increases vascular contractility in a mouse model of type 1 diabetes
Published in British journal of pharmacology (01-12-2010)“…BACKGROUND AND PURPOSE Vasculopathies represent the main cause of morbidity and mortality in diabetes. Vascular malfunctioning in diabetes is associated with…”
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Journal Article -
11
Endothelium dysfunction in LDL receptor knockout mice: a role for H2O2
Published in British journal of pharmacology (01-04-2003)“…In this study, the role of endogenous H2O2 as an endothelium‐dependent relaxant factor was characterised in aortas from C57BL/6J and LDL receptor‐deficient…”
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12
Effects of the Brazilian phytopharmaceutical product Ierobina ® on lipid metabolism and intestinal tonus
Published in Journal of ethnopharmacology (14-11-2005)“…Ierobina ® is a Brazilian phytopharmaceutical product indicated for the treatment of dyspepsia. It contains the hydroethanolic extracts of Solanum paniculatum…”
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13
Angiotensin‐(1‐7) is involved in the endothelium‐dependent modulation of phenylephrine‐induced contraction in the aorta of mRen‐2 transgenic rats
Published in British journal of pharmacology (01-04-2002)“…The contribution of the local vascular production of angiotensin‐(1‐7) [Ang‐(1‐7)] to the control of α‐adrenergic‐induced contractions in the aorta of…”
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14
Pharmacological evidence for the activation of potassium channels as the mechanism involved in the hypotensive and vasorelaxant effect of dioclein in rat small resistance arteries
Published in British journal of pharmacology (01-07-2001)“…The hypotensive and vasorelaxant effect of dioclein in resistance mesenteric arteries was studied in intact animals and isolated vessels, respectively. In…”
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Journal Article -
15
Activation of Nitric Oxide Modulator Effect by Isometric Contraction in Rat Resistance Arteries
Published in Journal of cardiovascular pharmacology (01-01-2006)“…The participation of nitric oxide (NO) as a modulator of the isometric contraction, as well as the underlying mechanism, was investigated in rat small…”
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16
Mechanism involved in the spasmolytic effect of a mixture of two triterpenes, cycloartenol and cycloeucalenol, isolated from Herissanthia tiubae in the guinea-pig ileum
Published in Planta medica (01-11-2005)“…The smooth muscle relaxant properties of a mixture of the two triterpenoids cycloeuclalenol and cycloartenol (CC) isolated from Herissanthia tiubae (Malvaceae)…”
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17
Dioclein, a new nitric oxide- and endothelium-dependent vasodilator flavonoid
Published in European journal of pharmacology (10-12-1999)“…In the present work, the vasorelaxant effect of dioclein, a new flavonoid isolated from Dioclea grandiflora (Leguminoseae), was investigated in the rat aorta…”
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18
Antiarrhythmogenic and antioxidant effect of the flavonoid dioclein in a model of cardiac ischemia/reperfusion
Published in Planta medica (01-03-2006)“…The antiarrhythmogenic effect of the flavonoid dioclein on myocardial ischemia/reperfusion was investigated in isolated perfused rat hearts. Low concentrations…”
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19
Mechanism of endothelium-dependent vasodilation induced by a proanthocyanidin-rich fraction from Ouratea semiserrata
Published in Planta medica (01-05-2002)“…The vasodilator effects of Ouratea semiserrata stem hydroethanolic extract (OSE) and its ethyl acetate fraction (OSR) were evaluated in endothelium-intact…”
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20
Inhibitory effect of the norlignan 2-(2'-hydroxy-4',6'-dimethoxyphenyl)-5-[(E)-propenyl]benzofuran from Krameria tomentosa on acetylcholine-induced relaxation of the rat aorta
Published in Planta medica (01-01-2006)“…In this work, we studied the effect of the norlignan 2-(2'-hydroxy-4',6'-dimethoxyphenyl)-5-[( E)-propenyl]benzofuran (DMPP) in the rat aorta. In aortic rings…”
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