Search Results - "Lemontt, Jeffrey F."

Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria by Sarkissian, Christineh N, Gámez, Alejandra, Wang, Lin, Charbonneau, Marilyse, Fitzpatrick, Paul, Lemontt, Jeffrey F, Zhao, Bin, Vellard, Michael, Bell, Sean M, Henschell, Carroll, Lambert, Amy, Tsuruda, Laurie, Stevens, Raymond C, Scriver, Charles R

“…Phenylketonuria (PKU) is a metabolic disorder, in which loss of phenylalanine hydroxylase activity results in neurotoxic levels of phenylalanine. We used the…”
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Long-term intra-articular administration of recombinant human N-acetylgalactosamine-4-sulfatase in feline mucopolysaccharidosis VI by Auclair, Dyane, Hopwood, John J., Lemontt, Jeffrey F., Chen, Lin, Byers, Sharon

“…Degenerative joint disease (DJD) is one aspect of mucopolysaccharidosis VI (MPS VI) pathology that has proven resistant to systemic enzyme replacement therapy…”
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Structural and Biochemical Characterization of the Therapeutic Anabaena variabilis Phenylalanine Ammonia Lyase by Wang, Lin, Gamez, Alejandra, Archer, Holly, Abola, Enrique E., Sarkissian, Christineh N., Fitzpatrick, Paul, Wendt, Dan, Zhang, Yanhong, Vellard, Michel, Bliesath, Joshua, Bell, Sean M., Lemontt, Jeffrey F., Scriver, Charles R., Stevens, Raymond C.

“…We have recently observed promising success in a mouse model for treating the metabolic disorder phenylketonuria with phenylalanine ammonia lyase (PAL) from…”
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Development of a functional bioassay for arylsulfatase B using the natural substrates of the enzyme by Pungor, Erno, Hague, Charles M., Chen, Ginger, Lemontt, Jeffrey F., Dvorak-Ewell, Melita, Prince, William S.

“…A functional bioassay has been developed for measuring the intracellular activity of recombinant human arylsulfatase B (rhASB) on its natural glycosaminoglycan…”
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Structure-based epitope and PEGylation sites mapping of phenylalanine ammonia-lyase for enzyme substitution treatment of phenylketonuria by Gámez, Alejandra, Wang, Lin, Sarkissian, Christineh N., Wendt, Dan, Fitzpatrick, Paul, Lemontt, Jeffrey F., Scriver, Charles R., Stevens, Raymond C.

“…Protein and peptide therapeutics are of growing importance as medical treatments but can frequently induce an immune response. This work describes the…”
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Replacement therapy in Mucopolysaccharidosis type VI: advantages of early onset of therapy by Auclair, Dyane, Hopwood, John J., Brooks, Douglas A., Lemontt, Jeffrey F., Crawley, Allison C.

“…This study evaluates the immunological response following weekly 2 h infusions of recombinant human N-acetylgalactosamine 4-sulfatase (rh4S) in…”
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Development of pegylated forms of recombinant Rhodosporidium toruloides phenylalanine ammonia-lyase for the treatment of classical phenylketonuria by Gámez, Alejandra, Sarkissian, Christineh N, Wang, Lin, Kim, Woomi, Straub, Mary, Patch, Marianne G, Chen, Lin, Striepeke, Steve, Fitzpatrick, Paul, Lemontt, Jeffrey F, O'Neill, Charles, Scriver, Charles R, Stevens, Raymond C

“…Phenylketonuria (PKU) is a metabolic disorder due primarily to mutations in the PAH gene that impair both phenylalanine hydroxylase activity and disposal of…”
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Mutants of yeast defective in mutation induced by ultraviolet light by Lemontt, J F

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Mannose 6-Phosphate Conjugation Is Not Sufficient to Allow Induction of Immune Tolerance to Phenylalanine Ammonia-Lyase in Dogs by Vera, Moin, Lester, Thomas, Zhao, Bin, Tiger, Pascale, Clarke, Scott, Tippin, Brigette L., Passage, Merry B., Le, Steven Q., Femenia, Javier, Lemontt, Jeffrey F., Kakkis, Emil D., Dickson, Patricia I.

“…The immune response to exogenous protein has been shown to reduce therapeutic efficacy in animal models of enzyme replacement therapy. A previously published…”
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Increased mdr gene expression and decreased drug accumulation in multidrug-resistant human melanoma cells by LEMONTT, J. F, AZZARIA, M, GROS, P

“…Multidrug-resistant clones of a drug-sensitive human malignant melanoma cell line were isolated by single-step selection in culture medium containing either…”
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Pleiotropic mutations at the tup1 locus that affect the expression of mating-type-dependent functions in Saccharomyces cerevisiae [Yeasts] by Lemontt, Jeffrey F, Fugit, Donna R, Mackay, Vivian L

“…The umr7-1 mutation, previously identified in a set of mutants that had been selected for defective UV-induced mutagenesis at CAN1, affects other cellular…”
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Eukaryotic Microbes The Eukaryotic Microbial Cell G. W. Gooday D. Lloyd A. P. J. Trinci by Lemontt, Jeffrey F.

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The eukaryotic microbial cell by Lemontt, Jeffrey F

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Eukaryotic Microbes by Lemontt, Jeffrey F.

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Induced mutagenesis in Ustilago maydis. I. Isolation and characterization of a radiation-revertible allele of the structural gene for nitrate reductase by Lemontt, J F

“…A UV-revertible mutant of the nar1 structural gene for nitrate reductase was isolated in wild-type (nar+ nir+) Ustilago maydis. It proved to be vigorously…”
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Induced mutagenesis in Ustilago maydis. II. An in vivo biochemical assay by Lemontt, J F

“…UV gamma radiation-induced reversion to nar+ in a nar1-m nir1-1 strain of Ustilago maydis was found to occur under nongrowth conditions by performing the in…”
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Induction of forward mutations in mutationally defective yeast by Lemontt, J F

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Pathways of ultraviolet mutability in Saccharomyces Cerevisiae. IV. The relation between canavanine toxicity and ultraviolet mutability to canavanine resistance by Lemontt, J F

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Mutagenesis of yeast by hydrazine: dependence upon post-treatment cell division by Lemontt, J F

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Pathways of ultraviolet mutability in Saccharomyces cerevisiae. II. The effect of rev genes on recombination by Lemontt, J F

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