Search Results - "Lemon, Bryan D"

TRANSCRIPTIONAL COACTIVATOR COMPLEXES by Näär, Anders M, Lemon, Bryan D, Tjian, Robert

“…The last two decades have witnessed a tremendous expansion in our knowledge of the mechanisms employed by eukaryotic cells to control gene activity. A critical…”
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Preclinical Characterization of HPN536, a Trispecific, T-Cell-Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors by Molloy, Mary Ellen, Austin, Richard J, Lemon, Bryan D, Aaron, Wade H, Ganti, Vaishnavi, Jones, Adrie, Jones, Susan D, Strobel, Kathryn L, Patnaik, Purbasa, Sexton, Kenneth, Tatalick, Laurie, Yu, Timothy Z, Baeuerle, Patrick A, Law, Che-Leung, Wesche, Holger

“…Mesothelin (MSLN) is a glycophosphatidylinositol-linked tumor antigen overexpressed in a variety of malignancies, including ovarian, pancreatic, lung, and…”
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TriTACs, a Novel Class of T-Cell-Engaging Protein Constructs Designed for the Treatment of Solid Tumors by Austin, Richard J, Lemon, Bryan D, Aaron, Wade H, Barath, Manasi, Culp, Patricia A, DuBridge, Robert B, Evnin, Luke B, Jones, Adrie, Panchal, Anand, Patnaik, Purbasa, Ramakrishnan, Vanitha, Rocha, Sony S, Seto, Pui, Sexton, Kenneth, Strobel, Kathryn L, Wall, Russell, Yu, Stephen, Yu, Timothy Z, Law, Che-Leung, Baeuerle, Patrick A, Wesche, Holger

“…T cells have a unique capability to eliminate cancer cells and fight malignancies. Cancer cells have adopted multiple immune evasion mechanisms aimed at…”
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Nuclear receptor cofactors as chromatin remodelers by Lemon, Bryan D, Freedman, Leonard P

“…Nuclear receptors regulate transcription in direct response to their cognate hormonal ligands. Ligand binding leads to the dissociation of corepressors and the…”
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HPN328, a Trispecific T Cell-Activating Protein Construct Targeting DLL3-Expressing Solid Tumors by Molloy, Mary E, Aaron, Wade H, Barath, Manasi, Bush, Mabel C, Callihan, Evan C, Carlin, Kevin, Cremin, Michael, Evans, Thomas, Guerrero, Maria G, Hemmati, Golzar, Hundal, Avneel S, Lao, Llewelyn, Laurie, Payton, Lemon, Bryan D, Lin, S J, O'Rear, Jessica, Patnaik, Purbasa, Sotelo Rocha, Sony, Santiago, Linda, Strobel, Kathryn L, Valenzuela, Laura B, Wu, Chi-Heng, Yu, Stephen, Yu, Timothy Z, Anand, Banmeet S, Law, Che-Leung, Sun, Liping L, Wesche, Holger, Austin, Richard J

“…Delta-like ligand 3 (DLL3) is expressed in more than 70% of small cell lung cancers (SCLCs) and other neuroendocrine-derived tumor types. SCLC is highly…”
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Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex by Freedman, Leonard P, Rachez, Christophe, Lemon, Bryan D, Suldan, Zalman, Bromleigh, Virginia, Gamble, Matthew, Näär, Anders M, Erdjument-Bromage, Hediye, Tempst, Paul

“…Nuclear receptors modulate the transcription of genes in direct response to small lipophilic ligands. Binding to ligands induces conformational changes in the…”
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Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo by Lemon, Bryan D., Freedman, Leonard P.

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Abstract 913: FLT3-targeting TriTACs are T cell engagers for treatment of acute myeloid leukemia by Austin, Richard J., Aaron, Wade H., Barath, Manasi, Callihan, Evan, Gatto, Scott, Hemmati, Golzar, Law, Che-Leung, Lemon, Bryan D., O'Rear, Jessica, Patnaik, Purbasa, Thompson, Morgan, To, Lihn, Wesche, Holger, Wright, Kevin, Xiao, Yinghua, Yu, Stephen, Yu, Timothy Z.

“…Abstract FLT3 (fms related receptor tyrosine kinase 3) is a cell surface protein expressed in hematopoietic stem and progenitor cell populations1. FLT3 RNA is…”
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Selective Effects of Ligands on Vitamin D 3 Receptor- and Retinoid X Receptor-Mediated Gene Activation In Vivo by Lemon, Bryan D., Freedman, Leonard P.

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Retinoid X receptor:vitamin D3 receptor heterodimers promote stable preinitiation complex formation and direct 1,25-dihydroxyvitamin D3-dependent cell-free transcription by Lemon, Bryan D., Fondell, Joseph D., Freedman, Leonard P.

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Retinoid X Receptor:Vitamin D 3 Receptor Heterodimers Promote Stable Preinitiation Complex Formation and Direct 1,25-Dihydroxyvitamin D 3 -Dependent Cell-Free Transcription by Lemon, Bryan D., Fondell, Joseph D., Freedman, Leonard P.

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Vitamin D3-retinoid X receptor dimerization, DNA binding, and transactivation are differentially affected by analogs of 1,25-dihydroxyvitamin D3 by Cheskis, B, Lemon, B D, Uskokovic, M, Lomedico, P T, Freedman, L P

“…A number of analogs of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] have been synthesized that act as more potent inducers of cellular differentiation and…”
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