Search Results - "Lemmon, Marilyn"

Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents by Johnson, Leisa, Shen, Annie, Boyle, Larry, Kunich, John, Pandey, Kusum, Lemmon, Marilyn, Hermiston, Terry, Giedlin, Marty, McCormick, Frank, Fattaey, Ali

“…We have engineered a human adenovirus, ONYX-411, that selectively replicates in human tumor cells, but not normal cells, depending upon the status of their…”
Get full text

Efficacy with a Replication-selective Adenovirus Plus Cisplatin-based Chemotherapy: Dependence on Sequencing but not p53 Functional Status or Route of Administration by HEISE, Carla, LEMMON, Marilyn, KIRN, David

“…Replication-selective adenoviruses are being developed as novel anticancer therapeutics. Clinical trials with dl 1520, an E1B- M r 55,000 gene-deleted…”
Get full text

Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors by BROWN, J. M, LEMMON, M. J

“…The new bioreductive drug 3-amino-1,2,4-benzotriazine 1,4-dioxide (SR 4233) shows a high selective cytotoxicity for hypoxic cells, both in vitro and in tumors…”
Get full text

The Influence of Irradiation of the Tumor Bed on Tumor Hypoxia: Measurements by Radiation Response, Oxygen Electrodes, and Nitroimidazole Binding by Kim, Il Han, Lemmon, Marilyn J., Brown, J. Martin

“…SCCVII carcinomas and RIF-1 sarcomas were transplanted and grown in the unirradiated (control tumors) or preirradiated tissue of mice. Tumor oxygenation was…”
Get full text

A prodrug strategy using ONYX-015-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-38 by Stubdal, Hilde, Perin, Noah, Lemmon, Marilyn, Holman, Patricia, Bauzon, Maxine, Potter, Philip M, Danks, Mary K, Fattaey, Ali, Dubensky, Thomas, Johnson, Leisa

“…ONYX-015 has been used successfully in the clinic as a cancer therapeutic in combination with chemotherapy. The combination of ONYX-015 and chemotherapy…”
Get full text

A prodrug strategy using ONYX-015-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-381 by STUBDAL, Hilde, PERIN, Noah, LEMMON, Marilyn, HOLMAN, Patricia, BAUZON, Maxine, POTTER, Philip M, DANKS, Mary K, FATTAEY, Ali, DUBENSKY, Thomas, JOHNSON, Leisa

Get full text

SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells by Zeman, E M, Brown, J M, Lemmon, M J, Hirst, V K, Lee, W W

“…We have examined the effects of the benzotriazine di-N-oxide SR-4233 (3-amino-1,2,4-benzotriazine-1,4 dioxide) on a variety of aerobic and hypoxic cells in…”
Get more information

Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation by Brown, J M, Lemmon, M J

“…The present study describes a new way in which tumors may be made more sensitive to fractionated irradiation without affecting the sensitivity of surrounding…”
Get more information

SR 4233: a tumor specific radiosensitizer active in fractionated radiation regimes by Brown, J M, Lemmon, M J

“…The benzotriazine SR 4233, in addition to preferential killing of hypoxic cells both in vitro and in vivo, also radiosensitizes aerobic cells in vitro if the…”
Get more information

Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233 by Zeman, E M, Hirst, V K, Lemmon, M J, Brown, J M

“…SR 4233 (3-amino-1,2,4-benzotriazine 1,4-dioxide) is the lead compound in a series of benzotriazine di-N-oxides which exhibit high selective killing of hypoxic…”
Get more information

Mechanism of action of the selective tumor radiosensitizer nicotinamide by Horsman, M R, Brown, J M, Hirst, V K, Lemmon, M J, Wood, P J, Dunphy, E P, Overgaard, J

“…Nicotinamide has been shown to selectively enhance the radiation damage of tumors in preference to normal tissues. Our present study was an investigation into…”
Get more information

Pharmacological modification of tumor blood flow: lack of correlation between alteration of mean arterial blood pressure and changes in tumor perfusion by Stone, H B, Minchinton, A I, Lemmon, M, Menke, D, Brown, J M

“…The correlation between mean arterial blood pressure (MABP) and vascular perfusion in SCC-VII/St tumors in mice was compared following administration of three…”
Get more information

Response to Adams by Brown, J M, Lemmon, M

Get more information

Aerobic radiosensitization by SR 4233 in vitro and in vivo by Zeman, E M, Lemmon, M J, Brown, J M

“…During the past 3 years, our laboratory has identified and characterized the drug SR 4233 (3-amino-1,2,4-benzotriazine 1,4-dioxide) as the lead compound in a…”
Get more information

Second-generation 1,2,4-benzotriazine 1,4-di-N-oxide bioreductive anti-tumor agents: pharmacology and activity in vitro and in vivo by Minchinton, A I, Lemmon, M J, Tracy, M, Pollart, D J, Martinez, A P, Tosto, L M, Brown, J M

“…SR 4233 (1,2,4-benzotriazine-3-amine 1,4-dioxide) will soon be entering Phase I clinical trials as a new bioreductive cytotoxic agent for the treatment of…”
Get more information

Preferential tumor radiosensitization by analogs of nicotinamide and benzamide by Horsman, M R, Brown, D M, Lemmon, M J, Brown, J M, Lee, W W

“…The effects of a range of different analogs of nicotinamide and benzamide on the X ray response of the EMT-6 tumor in vivo was investigated. Using an in…”
Get more information