Search Results - "Lemieux, William"
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Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector
Published in Frontiers in immunology (16-12-2019)“…NK-cell resistance to transduction is a major technical hurdle for developing NK-cell immunotherapy. By using Baboon envelope pseudotyped lentiviral vectors…”
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Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion
Published in Scientific reports (30-09-2023)“…Neuroblastoma, the most common type of pediatric extracranial solid tumor, causes 10% of childhood cancer deaths. Despite intensive multimodal treatment, the…”
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3
KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors
Published in Frontiers in immunology (21-08-2023)“…Natural Killer (NK) cells hold the potential to shift cell therapy from a complex autologous option to a universal off-the-shelf one. Although NK cells have…”
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Dissecting the impact of molecular T-cell HLA mismatches in kidney transplant failure: A retrospective cohort study
Published in Frontiers in immunology (24-11-2022)“…Kidney transplantation is the optimal treatment in end-stage kidney disease, but donor specific antibody development continues to negatively impact patients…”
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Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming
Published in Oncotarget (24-05-2016)Get full text
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401.8: Dissecting the Impact of Molecular T-Cell HLA Mismatches in Kidney Graft Failure: A Retrospective Cohort Study
Published in Transplantation (01-09-2022)Get full text
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7
A registry‐based population study of the HLA in Québec, Canada
Published in HLA : immune response genetics (01-12-2023)“…As part of the worldwide effort to better characterize HLA diversity in populations, we have studied the population of Québec in Canada. This province has been…”
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Matchmaker, matchmaker make me a match: Opportunities and challenges in optimizing compatibility of HLA eplets in transplantation
Published in International journal of immunogenetics (01-04-2021)“…The development of donor‐specific antibodies (DSAs) is a major complication in transplantation, which is associated with inferior graft survival, impaired…”
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Patients’ NK cell stimulation with activated plasmacytoid dendritic cells increases dinutuximab-induced neuroblastoma killing
Published in Cancer Immunology, Immunotherapy (01-09-2020)“…Targeted immunotherapy has improved the outcome of patients with high-risk neuroblastoma (NB). However, immune escape of tumor cells still occurs and about 40%…”
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Abstract 28 Comparative Analysis of the Cord Blood Bank in Quebec
Published in Stem cells translational medicine (06-09-2022)“…Abstract Introduction In the context of the regional diversity observed in the population of Quebec, the Héma-Québec Cord Blood Bank (HQ CBB) representation…”
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Abstract 25 ECTmatch: Optimizing Small-Scale Cord Blood Banking Through HLA Analysis
Published in Stem cells translational medicine (06-09-2022)“…Abstract Introduction Cord blood (CB) banks have had to rely on large inventories of CB units to try to serve the largest possible proportion of the…”
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Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming
Published in Oncotarget (24-05-2016)“…Human mesenchymal stromal cells (MSC) have been shown to dampen immune response and promote tissue repair, but the underlying mechanisms are still under…”
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The most frequent HLA alleles around the world: A fundamental synopsis
Published in Best practice & research. Clinical haematology (01-06-2024)“…A comprehensive knowledge of human leukocyte antigen (HLA) molecular variation worldwide is essential in human population genetics research and disease…”
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Generation of functional human T cell development in NOD/SCID/IL2rγnull humanized mice without using fetal tissue: Application as a model of HIV infection and persistence
Published in Stem cell reports (14-02-2023)“…Humanization of mice with functional T cells currently relies on co-implantation of hematopoietic stem cells from fetal liver and autologous fetal thymic…”
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Implication of different effector mechanisms by cord blood–derived and peripheral blood–derived cytokine-induced killer cells to kill precursor B acute lymphoblastic leukemia cell lines
Published in Cytotherapy (Oxford, England) (01-06-2014)“…Abstract Background aims Cytokine-induced killer (CIK) cells ex vivo –expanded from cord blood (CB) or peripheral blood (PB) have been shown to be cytotoxic…”
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Moral leadership in the Lincoln presidency and implications for educational leaders
Published 01-01-2005“…This dissertation examines and identifies the moral leadership attributes of the Lincoln presidency and its implications for educational leaders through the…”
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Dissertation -
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Moral leadership in the Lincoln presidency and implications for educational leaders
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Dissertation