Search Results - "Lemieux, Jacob"

Analysis of the Borreliaceae Pangenome Reveals a Distinct Genomic Architecture Conserved Across Phylogenetic Scales by Lemieux, Jacob E

“…Abstract The family Borreliaceae contains arthropod-borne spirochetes that cause two widespread human diseases, Lyme disease and relapsing fever. Lyme disease…”
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Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant by Yurkovetskiy, Leonid, Wang, Xue, Pascal, Kristen E., Tomkins-Tinch, Christopher, Nyalile, Thomas P., Wang, Yetao, Baum, Alina, Diehl, William E., Dauphin, Ann, Carbone, Claudia, Veinotte, Kristen, Egri, Shawn B., Schaffner, Stephen F., Lemieux, Jacob E., Munro, James B., Rafique, Ashique, Barve, Abhi, Sabeti, Pardis C., Kyratsous, Christos A., Dudkina, Natalya V., Shen, Kuang, Luban, Jeremy

“…The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide, reaching near fixation in a matter of months. Here we show that D614G…”
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Consulting the Oracle of SARS-CoV-2 Infection by Lemieux, Jacob E, Luban, Jeremy

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Lyme Disease in Humans by Radolf, Justin D, Strle, Klemen, Lemieux, Jacob E, Strle, Franc

“…Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by genospecies of the sensu lato complex. The ailment, widespread…”
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Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness by Obermeyer, Fritz, Jankowiak, Martin, Barkas, Nikolaos, Schaffner, Stephen F, Pyle, Jesse D, Yurkovetskiy, Leonid, Bosso, Matteo, Park, Daniel J, Babadi, Mehrtash, MacInnis, Bronwyn L, Luban, Jeremy, Sabeti, Pardis C, Lemieux, Jacob E

“…Repeated emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increased fitness underscores the value of rapid detection and…”
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Inferring selection effects in SARS-CoV-2 with Bayesian Viral Allele Selection by Jankowiak, Martin, Obermeyer, Fritz H, Lemieux, Jacob E

“…The global effort to sequence millions of SARS-CoV-2 genomes has provided an unprecedented view of viral evolution. Characterizing how selection acts on…”
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Wider recognition and greater understanding of postinfectious, antibiotic-refractory Lyme arthritis by Steere, Allen C, Lemieux, Jacob E

“…Lyme disease, caused by Borrelia burgdorferi (Bb), can progress to Lyme arthritis (LA). While most patients with LA respond successfully to antibiotic therapy,…”
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Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection by Boucau, Julie, Marino, Caitlin, Regan, James, Uddin, Rockib, Choudhary, Manish C., Flynn, James P., Chen, Geoffrey, Stuckwisch, Ashley M., Mathews, Josh, Liew, May Y., Singh, Arshdeep, Lipiner, Taryn, Kittilson, Autumn, Melberg, Meghan, Li, Yijia, Gilbert, Rebecca F., Reynolds, Zahra, Iyer, Surabhi L., Chamberlin, Grace C., Vyas, Tammy D., Goldberg, Marcia B., Vyas, Jatin M., Li, Jonathan Z., Lemieux, Jacob E., Siedner, Mark J., Barczak, Amy K.

“…Outpatients with Covid-19 were followed serially with frequent PCR and viral-culture assessments. The SARS-CoV-2 omicron (BA.1) variant could be cultured a…”
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Characterization of Virologic Rebound Following Nirmatrelvir-Ritonavir Treatment for Coronavirus Disease 2019 (COVID-19) by Boucau, Julie, Uddin, Rockib, Marino, Caitlin, Regan, James, Flynn, James P, Choudhary, Manish C, Chen, Geoffrey, Stuckwisch, Ashley M, Mathews, Josh, Liew, May Y, Singh, Arshdeep, Reynolds, Zahra, Iyer, Surabhi L, Chamberlin, Grace C, Vyas, Tammy D, Vyas, Jatin M, Turbett, Sarah E, Li, Jonathan Z, Lemieux, Jacob E, Barczak, Amy K, Siedner, Mark J

“…We enrolled 7 individuals with recurrent symptoms or antigen test conversion following nirmatrelvir-ritonavir treatment. High viral loads (median 6.1 log10…”
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Uncovering Ways That Emerging Severe Acute Respiratory Syndrome Coronavirus 2 Lineages May Increase Transmissibility by Lemieux, Jacob E, Li, Jonathan Z

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Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum by López-Barragán, María J, Lemieux, Jacob, Quiñones, Mariam, Williamson, Kim C, Molina-Cruz, Alvaro, Cui, Kairong, Barillas-Mury, Carolina, Zhao, Keji, Su, Xin-zhuan

“…It has been shown that nearly a quarter of the initial predicted gene models in the Plasmodium falciparum genome contain errors. Although there have been…”
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GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome by Hsu, Amy P., Johnson, Kirby D., Falcone, E. Liana, Sanalkumar, Rajendran, Sanchez, Lauren, Hickstein, Dennis D., Cuellar-Rodriguez, Jennifer, Lemieux, Jacob E., Zerbe, Christa S., Bresnick, Emery H., Holland, Steven M.

“…Previous reports of GATA2 mutations have focused on the coding region of the gene or full gene deletions. We recently identified 2 patients with novel…”
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Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination by Lemieux, Jacob E, Huang, Weihua, Hill, Nathan, Cerar, Tjasa, Freimark, Lisa, Hernandez, Sergio, Luban, Matteo, Maraspin, Vera, Bogovič, Petra, Ogrinc, Katarina, Ruzič-Sabljič, Eva, Lapierre, Pascal, Lasek-Nesselquist, Erica, Singh, Navjot, Iyer, Radha, Liveris, Dionysios, Reed, Kurt D, Leong, John M, Branda, John A, Steere, Allen C, Wormser, Gary P, Strle, Franc, Sabeti, Pardis C, Schwartz, Ira, Strle, Klemen

“…Lyme disease is the most common vector-borne disease in North America and Europe. The clinical manifestations of Lyme disease vary based on the genospecies of…”
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Persistent SARS-CoV-2 infection: significance and implications by Machkovech, Heather M, Hahn, Anne M, Garonzik Wang, Jacqueline, Grubaugh, Nathan D, Halfmann, Peter J, Johnson, Marc C, Lemieux, Jacob E, O'Connor, David H, Piantadosi, Anne, Wei, Wanting, Friedrich, Thomas C

“…SARS-CoV-2 causes persistent infections in a subset of individuals, which is a major clinical and public health problem that should be prioritised for further…”
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Neuropathological features of SARS-CoV-2 delta and omicron variants by Normandin, Erica, Valizadeh, Navid, Rudmann, Emily A, Uddin, Rockib, Dobbins, Sabrina T, MacInnis, Bronwyn L, Padera, Robert F, Siddle, Katherine J, Lemieux, Jacob E, Sabeti, Pardis C, Mukerji, Shibani S, Solomon, Isaac H

“…Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continually evolving resulting in variants with increased transmissibility, more…”
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Viral Lineages in the 2022 RSV Surge in the United States by Adams, Gordon, Moreno, Gage K., Petros, Brittany A., Uddin, Rockib, Levine, Zoe, Kotzen, Ben, Messer, Katelyn S., Dobbins, Sabrina T., DeRuff, Katherine C., Loreth, Christine M., Brock-Fisher, Taylor, Schaffner, Stephen F., Chaluvadi, Sushma, Kanjilal, Sanjat, Luban, Jeremy, Ozonoff, Al, Park, Daniel J., Turbett, Sarah E., Siddle, Katherine J., MacInnis, Bronwyn L., Sabeti, Pardis C., Lemieux, Jacob E.

“…A surge in RSV infections occurred across the United States in late 2022. In this report, multiple RSV lineages are identified as contributing to the surge…”
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SARS-CoV-2 Virologic Rebound With Nirmatrelvir-Ritonavir Therapy : An Observational Study by Edelstein, Gregory E, Boucau, Julie, Uddin, Rockib, Marino, Caitlin, Liew, May Y, Barry, Mamadou, Choudhary, Manish C, Gilbert, Rebecca F, Reynolds, Zahra, Li, Yijia, Tien, Dessie, Sagar, Shruti, Vyas, Tammy D, Kawano, Yumeko, Sparks, Jeffrey A, Hammond, Sarah P, Wallace, Zachary, Vyas, Jatin M, Barczak, Amy K, Lemieux, Jacob E, Li, Jonathan Z, Siedner, Mark J

“…Data are conflicting regarding an association between treatment of acute COVID-19 with nirmatrelvir-ritonavir (N-R) and virologic rebound (VR). To compare the…”
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Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome by Hsu, Amy P., Sampaio, Elizabeth P., Khan, Javed, Calvo, Katherine R., Lemieux, Jacob E., Patel, Smita Y., Frucht, David M., Vinh, Donald C., Auth, Roger D., Freeman, Alexandra F., Olivier, Kenneth N., Uzel, Gulbu, Zerbe, Christa S., Spalding, Christine, Pittaluga, Stefania, Raffeld, Mark, Kuhns, Douglas B., Ding, Li, Paulson, Michelle L., Marciano, Beatriz E., Gea-Banacloche, Juan C., Orange, Jordan S., Cuellar-Rodriguez, Jennifer, Hickstein, Dennis D., Holland, Steven M.

“…The syndrome of monocytopenia, B-cell and NK-cell lymphopenia, and mycobacterial, fungal, and viral infections is associated with myelodysplasia, cytogenetic…”
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Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19 by Conklin, John, Frosch, Matthew P., Mukerji, Shibani S., Rapalino, Otto, Maher, Mary D., Schaefer, Pamela W., Lev, Michael H., Gonzalez, R.G., Das, Sudeshna, Champion, Samantha N., Magdamo, Colin, Sen, Pritha, Harrold, G. Kyle, Alabsi, Haitham, Normandin, Erica, Shaw, Bennett, Lemieux, Jacob E., Sabeti, Pardis C., Branda, John A., Brown, Emery N., Westover, M. Brandon, Huang, Susie Y., Edlow, Brian L.

“…We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive…”
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Detection of Borrelia burgdorferi Cell-free DNA in Human Plasma Samples for Improved Diagnosis of Early Lyme Borreliosis by Branda, John A, Lemieux, Jacob E, Blair, Lily, Ahmed, Asim A, Hong, David K, Bercovici, Sivan, Blauwkamp, Timothy A, Hollemon, Desiree, Ho, Carine, Strle, Klemen, Damle, Nitin S, Lepore, Timothy J, Pollock, Nira R

“…Laboratory confirmation of early Lyme borreliosis (LB) is challenging. Serology is insensitive during the first days to weeks of infection, and blood…”
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