Search Results - "Lemes, Romélia Pinheiro"
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Effects of hydroxyurea on cytotoxicity, inflammation and oxidative stress markers in neutrophils of patients with sickle cell anemia: dose-effect relationship
Published in Hematology, Transfusion and Cell Therapy (01-10-2021)“…INTRODUCTIONAlthough the efficacy of hydroxyurea (HU) in inhibiting erythrocyte sickling has been well demonstrated, the action of this drug on human…”
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The Effect of a Selective Inhibitor of Phosphodiesterase‐9 on Oxidative Stress, Inflammation and Cytotoxicity in Neutrophils from Patients with Sickle Cell Anaemia
Published in Basic & clinical pharmacology & toxicology (01-04-2016)“…The aim of the study was to investigate the possible anti‐inflammatory and antioxidant effects of BAY 73‐6691 on neutrophils from SCA patients. This study…”
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Obliterans With Organizing Pneumonia: A Possible Misdiagnosis of Lung Graft-Versus-Host Disease in Posttransplant Patients With COVID-19
Published in Experimental and clinical transplantation (01-04-2021)“…Obliterans with organizing pneumonia (BOOP) is characterized by the presence of fibroblast proliferation within the lumen of the ducts and alveolar spaces, by…”
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Sickle Cell Disease and the Kidney: Pathophysiology and Novel Biomarkers
Published in Contributions to nephrology (01-01-2021)“…Clinical Background: Renal involvement in sickle cell disease (SCD), called sickle cell nephropathy (SCN), includes several renal manifestations, such as renal…”
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Synthesis, Antitumor and Cytotoxic Activity of New Adamantyl O‐Acylamidoximes and 3‐Aryl‐5‐Adamantane‐1,2,4‐Oxadiazole Derivatives
Published in ChemistrySelect (Weinheim) (23-08-2019)“…O‐Acylamidoxime and 1,2,4‐oxadiazole derivatives were synthesized from adamantanecarbonyl chloride 1 and a diversity of arylamidoximes 2 a‐k. First,…”
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Levothyroxine Replacement Improves Oxidative Status in Primary Hypothyroidism
Published in Frontiers in endocrinology (Lausanne) (08-11-2018)“…Although hypothyroidism has been linked to oxidative stress, data regarding the relationship between thyroid hormone levels and oxidative stress is still…”
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Production and Characterization of Melon Sulfated Pectin (Cucumis melo var. acidulus) Nanoparticles with Anticoagulant Potential
Published in Journal of young pharmacists (01-04-2020)“…Objective: Unfractionated heparin and low molecular weight heparin are the drugs most used today in coagulopathy. Although effective, these drugs have…”
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Genotoxicity associated with the use of tyrosine kinase inhibitors in patients with chronic myeloid leukemia
Published in Environmental and molecular mutagenesis (01-04-2018)Get full text
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Does BCR-ABL transcript type influence the prognosis of patients in chronic myelogenous leukemia chronic phase?
Published in Hematology, Transfusion and Cell Therapy (01-04-2019)“…In this study, we evaluated the influence of the transcript type on hematological and clinical parameters, as well as the event-free survival of 50 patients in…”
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Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns
Published in Biomarkers in medicine (17-08-2024)“…To evaluate the urinary biomarkers related to sepsis in preterm newborns (NBs) and to investigate the predictive capacity of these biomarkers for a longer…”
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Is chronic use of hydroxyurea safe for patients with sickle cell anemia? An account of genotoxicity and mutagenicity
Published in Environmental and molecular mutagenesis (01-04-2019)“…Sickle cell anemia (SCA) is a hereditary hematological disease that is characterized by a point mutation in the beta globin S gene and has no specific…”
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Non-invasive urinary biomarkers of renal function in sickle cell disease: an overview
Published in Annals of hematology (01-12-2019)“…Sickle cell disease (SCD) is a hereditary condition characterized by homozygosis of the hemoglobin S (HbS) gene. Marked morbimortality is observed due to…”
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Use of non-conventional biomarkers in the early diagnosis of acute kidney injury in preterm newborns with sepsis
Published in Brazilian Journal of Nephrology (01-01-2022)“…Acute kidney injury (AKI) is a common finding in Neotatal Intensive Care Units (NICU). Sepsis is one the main causes of AKI in preterm newborns. AKI has been…”
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Prolonged response to recombinant human erythropoietin treatment in patients with myelodysplastic syndrome at a single referral centre in Brazil
Published in Clinics (São Paulo, Brazil) (2019)“…To evaluate the effects of epoetin (EPO) alfa treatment on overall survival, event-free survival and response duration in patients with myelodysplastic…”
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Protocolo de tratamento do mieloma múltiplo: serviço de hematologia Hospital Universitário Walter Cantídio, abril - 2019
Published in Revista de medicina da Universidade Federal do Ceará (31-03-2020)“…O Mieloma Múltiplo (MM) é uma neoplasia hematológica caracterizada pela infiltração de medula óssea por plasmócitos clonais (malignos) e pela produção de uma…”
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Impact of Treatment Prior to Allogeneic Transplantation of Hematopoietic Stem Cells in Patients with Myelodysplastic Syndrome: Results of the Latin American Bone Marrow Transplant Registry
Published in Biology of blood and marrow transplantation (01-05-2020)“…•In pre-hematopoietic stem cell transplantation (HSCT) treated and untreated patients, there is no difference in survival.•The type of pre-HSCT treatment has a…”
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Linfoma de Hodgkin clássico: perfil de duas décadas em hospital de referência de uma cidade do nordeste do Brasil
Published in Revista de medicina da Universidade Federal do Ceará (25-08-2022)“…Objetivos: descrever o perfil epidemiológico e clínico dos pacientes com Linfoma de Hodgkin Clássico (LHc) tratados com o protocolo ABVD (doxorrubicina,…”
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Presence of new mutations in the TP53 gene in patients with low-risk myelodysplastic syndrome: two case reports
Published in Journal of medical case reports (21-05-2017)“…Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood…”
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Presence of CD34 + in Megakaryocytes in Association With p53 Expression Predicts Unfavorable Prognosis in Low-risk Myelodysplastic Syndrome Patients
Published in In vivo (Athens) (01-01-2019)“…Although risk stratification using the Prognostic Scores Systems (IPSS, WPSS and IPSS-R) incorporate key information about prognosis of patients with…”
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Influence of βS-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease
Published in Disease markers (01-01-2016)“…Introduction. Sickle cell disease (SCD) is characterized by hemoglobin S homozygosity, leading to hemolysis and vasoocclusion. The hemolysis releases arginase…”
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